Disorders of Phagocytic Cells

  • Nima Rezaei
  • Asghar Aghamohammadi
  • Michael H. Albert
  • Bernd H. Belohradsky
  • Teresa Espanol
  • Melinda Erdős
  • Christoph Klein
  • László Maródi
  • Payam Mohammadinejad
  • Thomas Nicolai
  • Gundula Notheis
  • Mona Hedayat
  • Shabnam Pourhamdi
  • Joachim Roesler
  • Sergio D. Rosenzweig
  • Uwe Wintergerst


Patients with defects in phagocytic function are predisposed to intracellular microorganisms and typically have early dissemination of the infection. Recognition of the underlying disorder and aggressive antimicrobial therapy has been beneficial for the patients. Improved understanding of the pathophysiology of the disorder has also affected patient management by allowing specific, targeted immunomodulatory interventions. The cases in this chapter are not common but have had a significant impact on our understanding of the role of phagocytic cells in host defense. Conversely, understanding the role of the neutrophils and macrophages in infection has benefited not just the patients described in this chapter but also other patients with similar disease process.


Correct Answer Chronic Granulomatous Disease Oral Ulcer Sinusoidal Obstruction Syndrome Chronic Granulomatous Disease Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Nima Rezaei
    • 1
    • 2
    • 3
  • Asghar Aghamohammadi
    • 4
  • Michael H. Albert
    • 5
  • Bernd H. Belohradsky
    • 6
  • Teresa Espanol
    • 7
  • Melinda Erdős
    • 8
  • Christoph Klein
    • 9
  • László Maródi
    • 8
  • Payam Mohammadinejad
    • 10
  • Thomas Nicolai
    • 6
  • Gundula Notheis
    • 11
  • Mona Hedayat
    • 15
  • Shabnam Pourhamdi
    • 10
  • Joachim Roesler
    • 12
  • Sergio D. Rosenzweig
    • 13
  • Uwe Wintergerst
    • 14
  1. 1.Department of ImmunologyResearch Center for Immunodeficiencies, Children’s Medical Center HospitalTehranIran
  2. 2.Molecular Immunology Research CenterTehranIran
  3. 3.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  4. 4.Division of Clinical Immunology and AllergyResearch Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical SciencesTehranIran
  5. 5.Department of Pediatric Hematology/Oncology, Bone Marrow Transplant UnitUniversity Children’s Hospital, Ludwig Maximilans UniversityMunichGermany
  6. 6.Department of Pediatric Hematology/OncologyUniversity Children’s Hospital, Ludwig Maximilans UniversityMunichGermany
  7. 7.Department of Immunology and Immunodeficiencies, School of MedicineUniversity Hospital Vall d’HebronBarcelonaSpain
  8. 8.Department of Infectious and Pediatric ImmunologyMedical and Health Science Center, University of DebrecenDebrecenHungary
  9. 9.Department of Pediatric Hematology, OncologyDr. von Haunersches Kinderspital, University Children’s HospitalMunichGermany
  10. 10.Department of PediatricsResearch Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical SciencesTehranIran
  11. 11.Primary Immunodeficiency ClinicUniversity Children’s Hospital, Ludwig Maximilans UniversityMunichGermany
  12. 12.Department of PediatricsUniversity HospitalDresdenGermany
  13. 13.Primary Immunodeficiency Clinic, Laboratory of Host DefensesNIAID, National Institute of HealthBethesdaUSA
  14. 14.Department of Infectious Diseases and ImmunologyHospital St. JosefBraunauAustria
  15. 15.Division of ImmunologyBoston Children’s HospitalMAUSA

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