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Predominantly Antibody Deficiency

  • Asghar Aghamohammadi
  • Hassan Abolhassani
  • Martha M. Eibl
  • Teresa Espanol
  • Hirokazu Kanegane
  • Toshio Miyawaki
  • Payam Mohammadinejad
  • Shabnam Pourhamdi
  • Hermann M. Wolf
  • Nima Parvaneh
  • Waleed Al-Herz
  • Anne Durandy
  • E. Richard Stiehm
  • Alessandro Plebani
Chapter

Abstract

Primary antibody deficiencies (PADs) are the most common type of PIDs, accounting for approximately half of the diseases [1–7]. The spectrum of PADs is broad, ranging from patients with a severe reduction of all serum immunoglobulin classes and totally absent B cells to patients who have a selective antibody deficiency with normal serum immunoglobulins [6]. Many of these disorders share a clinical phenotype with common features such as chronic and recurrent respiratory and gastrointestinal tracts infections, chronic inflammation, autoimmunity, and malignancy [8–10].

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Asghar Aghamohammadi
    • 1
  • Hassan Abolhassani
    • 4
  • Martha M. Eibl
    • 9
  • Teresa Espanol
    • 10
  • Hirokazu Kanegane
    • 11
  • Toshio Miyawaki
    • 11
  • Payam Mohammadinejad
    • 4
  • Shabnam Pourhamdi
    • 4
  • Hermann M. Wolf
    • 9
  • Nima Parvaneh
    • 4
    • 5
  • Waleed Al-Herz
    • 6
  • Anne Durandy
    • 7
    • 8
  • E. Richard Stiehm
    • 3
  • Alessandro Plebani
    • 2
  1. 1.Division of Clinical Immunology and AllergyResearch Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical SciencesTehranIran
  2. 2.Division of Clinical Immunology and Rheumatology, Department of Pediatrics Spedali CiviliUniversity of BresciaBresciaItaly
  3. 3.Division of Immunology/Allergy/RheumatologyMattel Children’s Hospital, UCLA School of MedicineLos AngelesUSA
  4. 4.Department of PediartricsResearch Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical SciencesTehranIran
  5. 5.Infectious Diseases Research Center, Tehran University of Medical SciencesTehranIran
  6. 6.Department of PediatricsKuwait UniversityKuwaitKuwait
  7. 7.Unité d’Immunologie et Hématologie PédiatriqueInstitut National de la Santé et de la Recherche Médicale U768, Hôpital Necker Enfants MaladesParisFrance
  8. 8.Faculté de MédecineUniversité Paris DescartesParisFrance
  9. 9.Department of PediatricsImmunological Outpatient Clinic, Biomedical Research InstituteViennaAustria
  10. 10.Department of Immunology and Immunodeficiencies, School of MedicineUniversity Hospital Vall d’HebronBarcelonaSpain
  11. 11.Department of PediatricsGraduate School of Medicine and Pharmaceutical, University of ToyamaToyamaJapan

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