Tumors and Tumor-Like Conditions of Bones

  • Hart IsaacsJr


Primary tumors of bone occur infrequently during the first year of life. Few cases have been reported [1–12]. For example, in a series of 249 children with bone lesions less than 10 years of age, 16 were younger than 1 year of age [1]. Langerhans cell histiocytosis was the dominant neoplasm (ten cases); the skull was the site most frequently involved (Fig. 18.1). In addition, there were two examples of chest wall hamartoma and one each of Ewing’s sarcoma of the scapula, fibrous dysplasia of the turbinate, osteochondroma of the rib, and myofibromatosis of the mandible [1].


Fibrous Dysplasia Neuroectodermal Tumor Aneurysmal Bone Cyst Polyostotic Fibrous Dysplasia Juvenile Xanthogranuloma 
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  1. 1.
    Senac MO Jr, Isaacs H Jr, Gwinn JL (1986) Primary lesions of bone in the 1st decade of life: retrospective survey of biopsy results. Radiology 160:491–495PubMedGoogle Scholar
  2. 2.
    Carney JA, Boccon-Gibod L, Jarka DE (2001) Osteochondromyxoma of bone. A congenital tumor associated with lentigines and other unusual disorders. Am J Surg Pathol 25:164–176PubMedCrossRefGoogle Scholar
  3. 3.
    Anderson MJ, Townsend DR, Johnston JO et al (1993) Osteofibrous dysplasia in the newborn: report of a case. J Bone Joint Surg Am 75:265–267PubMedGoogle Scholar
  4. 4.
    Coffin CM, Swanson PE, Wick MR (1993) Chordoma in childhood and adolescence. A clinicopathologic analysis of 12 cases. Arch Pathol Lab Med 117:927–933PubMedGoogle Scholar
  5. 5.
    Cohen D, Granda-Ricart MC (1993) Giant cell reparative granuloma of the base of the skull in a 4-month-old infant- CT findings. Pediatr Radiol 23:319–320PubMedCrossRefGoogle Scholar
  6. 6.
    Hsieth HY, Hsiao CC, Chen WS et al (1998) Congenital Ewing’s sarcoma of the humerus. Br J Radiol 71:1313–1316Google Scholar
  7. 7.
    Inwards CY, Unni KK, Beabout JW et al (1991) Solitary congenital fibromatosis (infantile myofibromatosis) of bone. Am J Surg Pathol 15:935–941PubMedCrossRefGoogle Scholar
  8. 8.
    Cohen MC, Drut R, Garcia C et al (1992) Mesenchymal hamartoma of the chest wall: a cooperative study with review of the literature. Pediatr Pathol 12:525–534PubMedCrossRefGoogle Scholar
  9. 9.
    Isaacs H Jr (1997) Tumors. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus and infant, 2nd edn. Mosby, St. Louis, pp 1240–1339Google Scholar
  10. 10.
    Rosenberg AE, Nielsen GP, Krishnasetty V, Rosenthal DI (2007) Disorders of the skeletal system including tumors. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus and infant, vol 2, 2nd edn. Mosby, Philadelphia, pp 1797–1897Google Scholar
  11. 11.
    Isaacs H Jr (1997) Bone tumors. In: Tumors of the fetus and newborn. Major problems in pathology, vol 35. W.B. Saunders, Philadelphia, pp 357–364Google Scholar
  12. 12.
    Isaacs H Jr (2002) Bone tumors. In: Isaacs H (ed) Tumors of the fetus and infant: an atlas. Springer, New York, pp 407–424Google Scholar
  13. 13.
    McCarthy EF, Dorfman HD (1980) Vascular and cartilaginous hamartoma of the ribs in infancy with secondary aneurysmal bone cyst formation. Am J Surg Pathol 4:247–253PubMedCrossRefGoogle Scholar
  14. 14.
    Jung AL, Johnson DG, Condon VR et al (1994) Congenital chest wall mesenchymal hamartoma. J Perinatol 14:487–491PubMedGoogle Scholar
  15. 15.
    Troum S, Dalton ML, Donner RS et al (1996) Multifocal mesenchymal hamartoma of the chest wall in infancy. J Pediatr Surg 31:713–715PubMedCrossRefGoogle Scholar
  16. 16.
    McDermott MB, Ponder TB, Dehner LP (1998) Nasal chondromesenchymal hamartoma. An upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol 22:425–433PubMedCrossRefGoogle Scholar
  17. 17.
    Hsueh C, Hsueh S, Gonzalez-Crussi F (2001) Nasal chondromesenchymal hamartoma in children. Report of 2 cases with review of the literature. Arch Pathol Lab Med 125:400–403PubMedGoogle Scholar
  18. 18.
    Kato K, Ijiri R, Tanaka Y (1999) Nasal chondromesenchymal hamartoma of infancy: the first Japanese case report. Pathol Int 49:731–736PubMedCrossRefGoogle Scholar
  19. 19.
    Kirk JMW, Brain CE, Carson DJ et al (1999) Cushing’s syndrome caused by nodular adrenal hyperplasia in children with McCune-Albright syndrome. J Pediatr 134:789–792PubMedCrossRefGoogle Scholar
  20. 20.
    Shenker A, Weinstein LS, Moran A et al (1993) Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein Gs. J Pediatr 123:509–518PubMedCrossRefGoogle Scholar
  21. 21.
    Fechner RE, Mills SE (1991) Tumors of the bones and joints. Atlas of tumor pathology, 3rd series, Fascicle 8. Armed Forces Institute of Pathology, Washington, D.C.Google Scholar
  22. 22.
    Chung EB, Enzinger FM (1981) Infantile myofibromatosis. Cancer 48:1807–1818PubMedCrossRefGoogle Scholar
  23. 23.
    Rosenberg HS, Stenback WA, Spjut HJ (1978) The fibromatoses of infancy and childhood. In: Rosenberg HS, Bolande RP (eds) Perspectives in pediatric pathology, vol 4. Year Book Medical Publishers, Chicago, pp 269–348Google Scholar
  24. 24.
    Chan YF, Lau JHK, Tong CY (1989) Congenital generalized fibromatosis predominant osseous involvement in a Chinese newborn. J Pediatr Orthop 9:64–68PubMedCrossRefGoogle Scholar
  25. 25.
    Zeller B, Storm-Mathisen I, Smevik B et al (1997) Cure of infantile myofibromatosis with severe respiratory complications without antitumor therapy. Eur J Pediatr 156:841–844PubMedCrossRefGoogle Scholar
  26. 26.
    Shields CL, Husson M, Shields JA et al (1998) Solitary intraosseous infantile myofibroma of the orbital roof. Arch Ophthalmol 116:1528–1530PubMedGoogle Scholar
  27. 27.
    Hasegawa M, Kida S, Yamashima T et al (1995) Multicentric infantile myofibromatosis in the cranium: case report. Neurosurgery 36:1200–1203PubMedCrossRefGoogle Scholar
  28. 28.
    Bernad L, Admella C, Lucaya J (1987) Infantile fibrosarcoma of femur. Pediatr Pathol 7:201–207CrossRefGoogle Scholar
  29. 29.
    Faure C, Gruner M, Boccon-Gibod L (1981) Case report 149. Skeletal Radiol 6:208–211PubMedCrossRefGoogle Scholar
  30. 30.
    Maygarden SJ, Askin FB, Siegel GP et al (1993) Ewing sarcoma of bone in infants and toddlers: a clinicopathologic report from the Intergroup Ewing’s Study. Cancer 71:2109–2118PubMedCrossRefGoogle Scholar
  31. 31.
    Dehner LP (1994) Neuroepithelioma (primitive neuroectodermal tumor) and Ewing’s sarcoma. At least a partial consensus. Arch Pathol Lab Med 118:606–607PubMedGoogle Scholar
  32. 32.
    Navarro S, Cavazzana AO, Llombart-Bosch A (1994) Comparison of Ewing’s sarcoma of bone and peripheral neuroepithelioma. An immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. Arch Pathol Lab Med 118:608–615PubMedGoogle Scholar
  33. 33.
    Dehner LP (1973) Tumors of the mandible and maxilla in children. II. A study of 14 primary and secondary malignant tumors. Cancer 32:112–120PubMedCrossRefGoogle Scholar
  34. 34.
    Walsh JW, Strand RD (1982) Melanotic neuroectodermal tumor of the neurocranium in infancy. Childs Brain 9:329–346PubMedGoogle Scholar
  35. 35.
    Matsumoto J, Towbin RB, Ball WS Jr (1989) Cranial chordomas in infancy and childhood. A report of two cases and review of the literature. Pediatr Radiol 20:28–32PubMedCrossRefGoogle Scholar
  36. 36.
    Oexle K, Dammann O, Bechmann B et al (1992) Intracranial chordoma in a neonate. Eur J Pediatr 151:336–338PubMedCrossRefGoogle Scholar
  37. 37.
    Probst EN, Zanella FE, Vortmeyer AO (1993) Congenital clivus chordoma. AJNR Am J Neuroradiol 14:537–579PubMedGoogle Scholar
  38. 38.
    Eggli KD, Caro P, Quiogue T et al (1992) Juvenile xanthogranuloma: non-X histiocytosis with systemic involvement. Pediatr Radiol 22:374–576PubMedCrossRefGoogle Scholar
  39. 39.
    Isaacs H (2006) Fetal and neonatal histiocytoses. Pediatr Blood Cancer 47:123–129PubMedCrossRefGoogle Scholar
  40. 40.
    Kulenkampff HA, Richter GM, Hassee WE et al (1990) Massive pelvic osteolysis in the Gorham-Stout syndrome. Int Orthop 14:361–366PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hart IsaacsJr
    • 1
  1. 1.Department of Pathology Rady Childrens Hospital San DiegoUniversity of California San Diego School of MedicineSan DiegoUSA

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