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Cardiac Tumors

  • Hart IsaacsJr
Chapter

Abstract

Cardiac tumors are rare in all age groups. The majority are histologically benign. Rhabdomyomas, the most common cardiac tumor in the fetus and infant, are most likely hamartomas (overgrowths of tissues normally present at the site of origin) rather than true neoplasms [1–9]. Because of their location, benign tumors and hamartomas of the heart may severely compromise blood flow, interfere with myocardial function, or cause arrhythmias leading to their clinical discovery, stillbirth, or to sudden death [1–3, 7]. Disturbances in hemodynamic function are correlated with the size and location of the tumor. Murmurs, cyanosis, respiratory distress, cardiac insufficiency, and arrhythmias are the main presenting signs, which should raise suspicion of an underlying cardiac tumor [6, 7]. Primary cardiac tumors are found more often than metastasis to the heart in infants [4, 7–9].

Keywords

Pericardial Effusion Tuberous Sclerosis Hypoplastic Left Heart Syndrome Cardiac Tumor Sudden Unexpected Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Arey JB (1984) Tumors of the heart and pericardium. In: Cardiovascular pathology in infants and children. Saunders, Philadelphia, pp 372–383Google Scholar
  2. 2.
    Freedom RM, Benson LN (1992) Cardiac neoplasms. In: Freedom RM, Benson LN, Smallhorn JF (eds) Neonatal heart disease. Springer, London, p 723CrossRefGoogle Scholar
  3. 3.
    Nadas AS, Ellison RC (1968) Cardiac tumors in infancy. Am J Cardiol 21:363–366PubMedCrossRefGoogle Scholar
  4. 4.
    Isaacs H Jr (1997) Cardiac tumors. In: Tumors of the fetus and newborn, vol 35. W.B. Saunders, Philadelphia, pp 330–343Google Scholar
  5. 5.
    Isaacs JR H (1997) Tumors. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus and infant, vol 2. Mosby, St. Louis, pp 1319–1323Google Scholar
  6. 6.
    Isaacs H Jr (2002) Tumors of the fetus and infant: an atlas. Springer, New York, pp 377–386Google Scholar
  7. 7.
    Isaacs HJR (2004) Fetal and neonatal cardiac tumors. Pediatr Cardiol 25:252–273PubMedCrossRefGoogle Scholar
  8. 8.
    Chan HS, Sonley MJ, Moes CA et al (1985) Primary and secondary tumors of childhood involving the heart, pericardium and great vessels. A report of 75 cases and review of the literature. Cancer 56:825–836PubMedCrossRefGoogle Scholar
  9. 9.
    Groves AMM, Fagg NLK, Cook AC et al (1992) Cardiac tumours in intrauterine life. Arch Dis Child 67:1189–1192PubMedCrossRefGoogle Scholar
  10. 10.
    Russell GA, Dhasmana JP, Berry PJ et al (1989) Coexistent cardiac tumours and malformations of the heart. Int J Cardiol 22:89–98PubMedCrossRefGoogle Scholar
  11. 11.
    McAllister HA JR, Fenoglio Jr JJ (1978) Tumors of the cardiovascular system, Fascicle 15, 2nd series. Armed Forces Institute of Pathology, Washington, D.C.Google Scholar
  12. 12.
    Isaacs H Jr (2008) Fetal hydrops associated with tumors. Am J Perinatol 25:43–68PubMedCrossRefGoogle Scholar
  13. 13.
    Holley DG, Martin GR, Brenner JI (1995) Diagnosis and management of fetal cardiac tumors: a multicenter experience and review of published reports. J Am Coll Cardiol 26:516–520PubMedCrossRefGoogle Scholar
  14. 14.
    Coffin CM (1992) Congenital cardiac fibroma associated with Gorlin syndrome. Pediatr Pathol 12:255–262PubMedCrossRefGoogle Scholar
  15. 15.
    Vidaillet HJ (1988) Cardiac tumors associated with hereditary syndromes. Am J Cardiol 61:1355PubMedCrossRefGoogle Scholar
  16. 16.
    Carney JA (1985) Differences between non-familial and familial cardiac myxoma. Am J Surg Pathol 9:53–55PubMedCrossRefGoogle Scholar
  17. 17.
    Smythe JF, Dyck JD, Smallhorn JF et al (1990) Natural history of cardiac rhabdomyoma in infancy and childhood. Am J Cardiol 66:1247–1249PubMedCrossRefGoogle Scholar
  18. 18.
    Webb DW, Thomas RD, Osborne JP (1993) Cardiac rhabdomyomas and their association with tuberous sclerosis. Arch Dis Child 68:367–370PubMedCrossRefGoogle Scholar
  19. 19.
    Burke AP, Virmani R (1991) Cardiac rhabdomyoma: a clinico-pathologic study. Mod Pathol 4:70–74PubMedGoogle Scholar
  20. 20.
    Fyler DC (1980) Report of the New England Regional Infant Cardiac Program. Pediatrics 65(suppl):376Google Scholar
  21. 21.
    Isaacs H (2009) Perinatal (fetal and neonatal) tuberous sclerosis: a review. Am J Perinatol 26:755–760PubMedCrossRefGoogle Scholar
  22. 22.
    Ostor AG, Fortune DW (1978) Tuberous sclerosis initially seen as hydrops fetalis: report of a case and review of the literature. Arch Pathol Lab Med 102:34–39PubMedGoogle Scholar
  23. 23.
    Isaacs H Jr (2004) Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg 39:1003–1013PubMedCrossRefGoogle Scholar
  24. 24.
    Costas C, Williams RL, Fortune RL (1986) Intracardiac teratoma in an infant. Pediatr Cardiol 7:179–181PubMedCrossRefGoogle Scholar
  25. 25.
    Bruch SW, Adzick NS, Reiss R et al (1997) Prenatal therapy for pericardial teratomas. J Pediatr Surg 32:1113–1115PubMedCrossRefGoogle Scholar
  26. 26.
    Catanzarite V, Mehalek K, Maida C et al (1994) Early sonographic diagnosis of intrapericardial teratoma. Ultrasound Obstet Gynecol 4:505–507PubMedCrossRefGoogle Scholar
  27. 27.
    Paw PT, Jamieson SW (1997) Surgical management of intrapericardial teratoma diagnosed in utero. Ann Thorac Surg 64:552–554PubMedCrossRefGoogle Scholar
  28. 28.
    Beghetti M, Gow RM, Haney I et al (1997) Pediatric primary benign cardiac tumors: a 15-year review. Am Heart J 134:1107–1114PubMedCrossRefGoogle Scholar
  29. 29.
    Gonzalez-Crussi F, Eberts TJ, Mirkin DL (1978) Congenital fibrous hamartoma of the heart. Arch Pathol Lab Med 102:491–493PubMedGoogle Scholar
  30. 30.
    Reddy JK, Shinke RN, Chang CHJ et al (1972) Beckwith–Wiedemann syndrome, Wilms’ tumor, cardiac hamartoma, persistent visceromegaly, and glomeruloneogenesis in a 2 year old boy. Arch Pathol 94:523–532PubMedGoogle Scholar
  31. 31.
    Rosenberg HS, Stenback WA, Spjut HJ (1978) The fibromatoses of infancy and childhood. In: Rosenberg HS, Bolande RP (eds) Perspectives in pediatric patholology, vol 4. Year Book, Chicago, pp 269–348Google Scholar
  32. 32.
    Back LM, Brown AS, Barot LR (1988) Congenital cardiac tumors in association with orofacial clefts. Ann Plast Surg 20:558–561PubMedCrossRefGoogle Scholar
  33. 33.
    Gorlin RJ (1987) Nevoid basal-cell carcinoma syndrome. Medicine 66:98–113PubMedCrossRefGoogle Scholar
  34. 34.
    Hals J, Ek J, Sandnes K (1990) Cardiac myxoma as the cause of death in an infant. Acta Paediatr Scand 79:999–1000PubMedCrossRefGoogle Scholar
  35. 35.
    Balsara RK, Pelias AJ (1983) Myxoma of right ventricle presenting as pulmonic stenosis in a neonate. Chest 83:145–146PubMedCrossRefGoogle Scholar
  36. 36.
    Burke A, Johns JP, Virmani R (1990) Hemangiomas of the heart. A clinicopathologic study of ten cases. Am J Cardiovasc Pathol 3:283–290PubMedGoogle Scholar
  37. 37.
    Platt LD, Geierman CA, Turkel SB et al (1982) Atrial hemangioma and hydrops fetalis. Am J Obstet Gynecol 141:107–109Google Scholar
  38. 38.
    Cartagena AM, Levin TL, Issenberg H et al (1993) Pericardial effusion and cardiac hemangioma in the neonate. Pediatr Radiol 23:384–385PubMedCrossRefGoogle Scholar
  39. 39.
    Thorp JA, Geidt A, Gelatt M et al (2000) Decompression of fetal cardiac tamponade caused by congenital capillary hemangioma of the pericardium. Obstet Gynecol 96:816–817PubMedCrossRefGoogle Scholar
  40. 40.
    Tseng JJ, Chou MM, Lee YH et al (1999) In utero diagnosis of cardiac hemangioma. Ultrasound Obstet Gynecol 13:363–365PubMedCrossRefGoogle Scholar
  41. 41.
    Daubeney PE, Ogilvie BC, Moore IE et al (1996) Intrapericardial lymphangioma presenting as neonatal cardiac tamponade. Pediatr Cardiol 17:129–131PubMedCrossRefGoogle Scholar
  42. 42.
    Baillie T, Chan YF, Koelmeyer TD et al (2001) Test and teach. III-defined subendocardial nodules in an infant. Histiocytoid cardiomyopathy. Pathology 33:230–234PubMedGoogle Scholar
  43. 43.
    Bird LM, Krous HF, Eichenfield LF et al (1994) Female infant with oncocytic cardiomyopathy and microphthalmia with linear skin defects (MLS): a clue to the pathogenesis of oncocytic cardiomyopathy? Am J Med Genet 53:141–148PubMedCrossRefGoogle Scholar
  44. 44.
    Franciosi RA, Singh A (1988) Oncocytic cardiomyopathy syndrome. Hum Pathol 19:1361–1362PubMedCrossRefGoogle Scholar
  45. 45.
    Gelb AB, Van Meter SH, Billingham ME et al (1993) Infantile ­histiocytoid cardiomyopathy – myocardial or conduction system hamartoma: what is the cell type involved? Hum Pathol 24:1226–1231PubMedCrossRefGoogle Scholar
  46. 46.
    Malhotra V, Ferrans VJ, Virmani R (1994) Infantile histiocytoid cardiomyopathy: three cases and literature review. Am Heart J 128:1009–1021PubMedCrossRefGoogle Scholar
  47. 47.
    Shehata BM, Patterson K, Thomas JE et al (1998) Histiocytoid cardiomyopathy: three new cases and a review of the literature. Pediatr Dev Pathol 1:56–69PubMedCrossRefGoogle Scholar
  48. 48.
    Bruton D, Herdson PB, Becroft DM (1977) Histiocytoid cardiomyopathy of infancy: an unexplained myofibre degeneration. Pathology 9:115–122PubMedCrossRefGoogle Scholar
  49. 49.
    Kearney DL, Titus JL, Hawkins EP et al (1987) Pathologic features of myocardial hamartomas causing childhood tachyarrhythmias. Circulation 75:705–710PubMedCrossRefGoogle Scholar
  50. 50.
    Silver MM, Burns JE, Sethi RK et al (1980) Oncocytic cardiomyopathy in an infant with oncocytosis in exocrine and endocrine glands. Hum Pathol 11:598–605PubMedCrossRefGoogle Scholar
  51. 51.
    Keller BB, Mehta AV, Shamszadeh M et al (1987) Oncocytic cardiomyopathy of infancy with Wolff–Parkinson–White syndrome and ectopic foci causing tachydysrhythmias in children. Am Heart J 114:782–792PubMedCrossRefGoogle Scholar
  52. 52.
    Murphy MC, Sweeney MS, Putnam JB Jr et al (1990) Surgical treatment of cardiac tumors: a 25-year experience. Ann Thorac Surg 49:612–617PubMedCrossRefGoogle Scholar
  53. 53.
    Schmaltz AA, Apitz J (1982) Primary rhabdomyosarcoma of the heart. Pediatr Cardiol 2:73–75PubMedCrossRefGoogle Scholar
  54. 54.
    Lazarus KH, D’Orsogna DE, Bloom KR et al (1989) Primary pericardial sarcoma in a neonate. Am J Pediatr Hematol Oncol 11:343–347PubMedGoogle Scholar
  55. 55.
    Small EJ, Gordon GJ, Dahms BB (1985) Malignant rhabdoid tumor of the heart in an infant. Cancer 55:2850–2853PubMedCrossRefGoogle Scholar
  56. 56.
    Isaacs H Jr (2006) Fetal and neonatal histiocytoses. Pediatr Blood Cancer 47:123–129PubMedCrossRefGoogle Scholar
  57. 57.
    Zimmerman KG, Paplanus SH, Dong S et al (1983) Congenital blood cysts of the heart valves. Hum Pathol 14:699–703PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hart IsaacsJr
    • 1
  1. 1.Department of Pathology Rady Childrens Hospital San DiegoUniversity of California San Diego School of MedicineSan DiegoUSA

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