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Adrenocortical Tumors

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Tumors of the Fetus and Infant

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Abstract

The adrenal cortex is the source of several tumors and tumorlike conditions with unusual clinical manifestations in the fetus and infant [1–19] (Table 13.1). Adrenocotical tumors (ACTs) are uncommon in this age group and throughout childhood. Relatively few examples of adrenal cysts, cortical adenomas, and carcinomas have been described, some in association with the Beckwith-Wiedemann syndrome, hemihypertrophy, cancer family (Li-Fraumeni) syndrome, or with other tumors [5, 6, 10]. Some ACTs exhibit structural abnormalities involving chromosome 11p15 and include loss of heterozygosity, paternal isodisomy, and overexpression of the gene for insulin-like growth factor II (IGF2) [20].

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  1. Department of Pathology Rady Childrens Hospital San Diego, University of California San Diego School of Medicine, San Diego, CA, USA

    Hart Isaacs Jr

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Isaacs, H. (2013). Adrenocortical Tumors. In: Tumors of the Fetus and Infant. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31620-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-31620-3_13

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