Abstract
Tumors and tumorlike conditions of the liver are uncommon in newborns and infants, comprising only 3 and 8 %, respectively, of the total neoplasms of various types [1, 2]. The incidence of malignant liver tumors during the first year of life as determined from the Third National Cancer Survey is 7.5 per million live births per year [3]. Hepatic malignancies ranked seventh as the cause of infant deaths from cancer in that survey. Hepatic tumors seldom occur in the perinatal period comprising approximately 5 % of the total neoplasms of different kinds occurring in this age group [1–3].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Isaacs H Jr (1997) Tumors. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus and infant, vol 2., pp 1242–1339
Isaacs H Jr (2002) Liver tumors. In: Tumors of the fetus and infant: an atlas. Springer, New York, pp 303–336
Bader JL, Miller RW (1979) Cancer incidence and mortality in the first year of life. Am J Dis Child 133:157–159
Dehner LP (1978) Hepatic tumors in the pediatric age group: a distinctive clinical pathologic spectrum. Perspect Pediatr Pathol 4:217–268
Dehner LP (1981) Neoplasms of the fetus and neonate. In: Naeye RL, Kissane JM, Kaufman N (eds) Perinatal diseases. International Academy of Pathology, Monograph number 22. Williams and Wilkins, Baltimore, p 286
Weinberg AG, Finegold MJ (1986) Primary hepatic tumors in childhood. In: Finegold M (ed) Pathology of neoplasia in children and adolescents, vol 18, Major problems in pathology. WB Saunders Co, Philadelphia
Isaacs H Jr (2007) Fetal and neonatal hepatic tumors. J Pediatr Surg 42:1797–1803
von Schweinitz D (2003) Neonatal liver tumours. Semin Neonatol 8:403–410
Isaacs H Jr (1985) Perinatal (congenital and neonatal) neoplasms: a report of 110 cases. Pediatr Pathol 3:165–216
Isaacs H Jr (2007) Tumors. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus, infant and child, vol 2, 2nd edn. Mosby-Elsevier, Philadelphia, pp 1677–1708
Stocker JT (1994) Hepatoblastoma. Semin Diagn Pathol 11:136–143
Lack EE, Neave C, Vawter GF (1982) Hepatoblastoma: a clinical and pathological study of 54 cases. Am J Surg Pathol 6:693–705
Ehren H, Mahour GH, Isaacs H Jr (1983) Benign liver tumors in infancy and childhood: report of 48 cases. Am J Surg 145:325
Stanley P, Geer GD, Miller JH et al (1989) Infantile hepatic hemangiomas: clinical features, radiologic investigations, and treatment of 20 patients. Cancer 64:936–949
Selby DM, Stocker JT, Waclawiw MA et al (1994) Infantile hemangioendothelioma of the liver. Hepatology 20:39–45
Isaacs H Jr (1997) Tumors of the fetus and newborn. W.B. Saunders, Philadelphia
Dreyfus M, Baldauf JJ, Dadoun K et al (1996) Prenatal diagnosis of hepatic hemangioma. Fetal Diagn Ther 11:57–60
Albano G, Pugliese A, Stabile M et al (1998) Hydrops foetalis caused by hepatic haemangioma. Acta Paediatr 87:1307–1309
Shturman-Ellstein R, Greco MA, Myrie C, Goldman EK (1978) Hydrops fetalis, hydramnios and hepatic vascular malformation associated with cutaneous hemangioma and chorangioma. Acta Paediatr Scand 67:239–243
Petrovic O, Haller H, Rukavina B et al (1992) Prenatal diagnosis of a large liver cavernous hemangioma associated with polyhydramnios. Prenat Diagn 12:70 (letter)
Noronha R, Gonzalez-Crussi F (1984) Hepatic angiosarcoma in a child. Am J Surg Pathol 8:863–871
Samuel M, Spitz L (1995) Infantile hepatic hemangioendothelioma: the role of surgery. J Pediatr Surg 30:1425–1429
Stocker JT, Ishak KG (1983) Mesenchymal hamartoma of the liver: report of 30 cases and review of the literature. Pediatr Pathol 1:245–267
DeMaioribus CA, Lally KP, Sim K et al (1990) Mesenchymal hamartoma: a 35-year review. Arch Surg 125:598–600
Dickinson JE, Knowles S, Phillips JM (1999) Prenatal diagnosis of hepatic mesenchymal hamartoma. Prenat Diagn 19:81–84
Hirata GI, Matsunaga MI, Medearis AL et al (1990) Ultrasonographic diagnosis of a fetal abdominal mass: a case of a mesenchymal liver hamartoma and a review of the literature. Prenat Diagn 10:507–512
Bessho T, Kubota K, Komori S et al (1996) Prenatally detected hepatic hamartoma: another cause of non-immune hydrops. Prenat Diagn 16:337–341
Tovbin J, Segal M, Tavori I et al (1997) Hepatic mesenchymal hamartoma: a pediatric tumor that may be diagnosed prenatally. Ultrasound Obstet Gynecol 10:63–65
Mascarello JT, Krous HF (1992) Second report of a translocation involving 19q13.4 in a mesenchymal hamartoma of the liver. Cancer Genet Cytogenet 58:141–142
de Chadarevian JP, Pawel BR, Faeber EN et al (1994) Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. Mod Pathol 7:490–493
Bove KE, Blough RI, Soukup S (1998) Third report of t(19q)(13.4) in mesenchymal hamartoma of the liver with comments on link to embryonal sarcoma. Pediatr Dev Pathol 1:438–442
Lennington WJ, Gray GF Jr, Page DL (1993) Mesenchymal hamartoma of liver: a regional ischemic lesion of a sequestered lobe. Am J Dis Child 147:193–196
Gonzalez-Crussi F, Upton MP, Mauer HS (1982) Hepatoblastoma: attempt at characterization of histologic subtypes. Am J Surg Pathol 6:599–612
Herzog CE, Andrassy RJ, Eftekhari F (2000) Childhood cancers: hepatoblastoma. Oncologist 5:445–453
Kazzi NJ, Chang C-H, Roberts EC et al (1989) Fetal hepatoblastoma presenting as non-immune hydrops. Am J Perinatol 6:278–280
Lee SC, Chung JW, Kim KH et al (1999) Successful transumbilical embolization of congenitally ruptured hepatoblastoma. J Pediatr Surg 34:1851–1852
Robinson HBJR, Bolande RP (1985) Fetal hepatoblastoma with placental metastases. Pediatr Pathol 4:163–167
Doss BJ, Vicari J, Jacques SM et al (1998) Placental involvement in congenital hepatoblastoma. Pediatr Dev Pathol 1:538–542
Hartley AL, Birch JM, Kelsey AM et al (1990) Epidemiological and familial aspects of hepatoblastoma. Med Pediatr Oncol 18:103–109
Orozco-Florian R, McBride JA, Favara BE et al (1991) Congenital hepatoblastoma and beckwith-wiedemann syndrome: a case study including DNA ploidy profiles tumor and adrenal cytomegaly. Pediatr Pathol 11:131–142
Sotelo-Avila C, Gooch WM (1976) Neoplasms associated with the Beckwith-Wiedemann syndrome. In: Rosenberg HS, Bolande RP (eds) Perspectives in pediatric pathology, vol II. Year Book Medical Publishers, Chicago, pp 255–272
Giardiello FM, Offerhaus GJA, Krush AJ et al (1991) Risk of hepatoblastoma in familial adenomatous polyposis. J Pediatr 119:766–768
Ikeda H, Hachitanda Y, Tanimura M et al (1998) Development of unfavorable hepatoblastoma in children of very low birth weight: results of a surgical and pathologic review. Cancer 82:1789–1796
Conran RM, Hitchcock CL, Waclawiw MA et al (1992) Hepatoblastoma: the prognostic significance of histologic type. Pediatr Pathol 12:167–183
Horie A, Kotoo Y, Hayashi I (1979) Ultrastructural comparison of hepatoblastoma and hepatocellular carcinoma. Cancer 44:2184–2193
Van Eyken P, Sciot R, Callea F et al (1990) A cytokeratin immunohisto-chemical study of hepatoblastoma. Hum Pathol 21:302–308
Fasano M, Theise ND, Nalesnik M et al (1998) Immunohistochemical evaluation of hepatoblastomas with use of hepatocyte-specific marker, hepatocyte paraffin 1, and the polyclonal anti-carcinoembryonic antigen. Mod Pathol 11:934–938
Gonzalez-Crussi F (1991) Case 1 undifferentiated small cell (“anaplastic”) hepatoblastoma. Pediatr Pathol 11:363
Hansen K, Bagtas J, Mark HF et al (1992) Undifferentiated small cell hepatoblastoma with a unique chromosomal translocation: a case report. Pediatr Pathol 12:457–462
Manivel C, Wick MR, Abenoza P et al (1986) Teratoid hepatoblastoma: the nosologic dilemma of solid embryonic neoplasms of childhood. Cancer 57:2168–2174
Cross SS, Variend S (1992) Combined hepatoblastoma and yolk sac tumor of the liver. Cancer 69:1323–1326
Meyers RL, Rowland JR, Krailo M et al (2009) Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer 53:1016–1022
Stocker JT, Ishak KG (1978) Undifferentiated (embryonal) sarcoma of the liver. Cancer 42:336–348
Aoyama C, Hachitanda Y, Sato JK et al (1991) Undifferentiated (embryonal) sarcoma of the liver: a tumor of uncertain histogenesis showing divergent differentiation. Am J Surg Pathol 15:615–624
Horowitz ME, Etcubanas E, Webber BL et al (1987) Hepatic undifferentiated (embryonal) sarcoma and rhabdomyosarcoma in children: results of therapy. Cancer 59:396–402
Hart WR (1975) Primary endodermal sinus (yolk sac) tumor of the liver: first reported case. Cancer 35:1453–1458
Atkinson JB, Foster CE III, Lally KP, Isaacs H, Siegel SE (1992) Primary endodermal sinus (yolk sac) tumor of the falciform ligament. J Pediatr Surg 27:105–107
Magnus KG, Millar AJ, Sinclair-Smith CC et al (1999) Intrahepatic fetus-in-fetu: a case report and review of the literature. J Pediatr Surg 34:1861–1864
Dehner LP, Parker ME, Franciosi RA et al (1979) Focal nodular hyperplasia and adenoma of the liver. A pediatric experience. Am J Pediatr Hematol Oncol 1:85–93
Lack EE, Ornvold K (1986) Focal nodular hyperplasia and hepatic adenoma: a review of eight cases in the pediatric age group. J Surg Oncol 33:129–135
Applegate KE, Ghei M, Perez-Atayde AR (1999) Prenatal detection of a solid liver adenoma. Pediatr Radiol 29:92–94
Stocker JT, Ishak KG (1981) Focal nodular hyperplasia of the liver: a study of 21 pediatric cases. Cancer 48:336–345
Moran CA, Mullick FG, Ishak KG (1991) Nodular regenerative hyperplasia of the liver in children. Am J Surg Pathol 15:449454
Scheimberg I, Cullinane C, Kelsey A et al (1996) Primary hepatic malignant tumor with rhabdoid features: a histological, immunocytochemical, and electron microscopic study of four cases and review of the literature. Am J Surg Pathol 20:1394–1400
Ohyama M, Ijiri R, Tanaka Y et al (2000) Congenital primitive epithelial tumor of the liver showing focal rhabdoid features, placental involvement and clinical features mimicking multifocal hemangioma or stage 4S neuroblastoma. Hum Pathol 31:259–263
Isaacs H (2010) Fetal and neonatal rhabdoid tumor. J Pediatr Surg 45:619–626
Siciliano M, De Candia E, Ballarin S et al (2000) Hepatocellular carcinoma complicating liver cirrhosis in type IIIa glycogen storage disease. J Clin Gastroenterol 31:80–82
Patterson K, Kapur SP, Chandra RS (1985) Hepatocellular carcinoma in a noncirrhotic infant after prolonged parenteral nutrition. J Pediatr 106:797–800
McGoldrick JP, Boston VE, Glasgow JF (1986) Hepatocellular carcinoma associated with congenital macronodular cirrhosis in a neonate. J Pediatr Surg 21:177–179
Jozwiak S, Pedich M, Rajszys P et al (1992) Incidence of hepatic hamartomas in tuberous sclerosis. Arch Dis Child 67:1363–1365
Shek TW, Ng IOL, Chan KW (1993) Inflammatory pseudotumor of the liver: report of four cases and review of the literature. Am J Surg Pathol 17:231–238
Takano H, Sato Y, Kao SCS et al (1997) Enlarging liver cyst in Beckwith-Wiedemann syndrome. Pediatr Radiol 27:619–620
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Isaacs, H. (2013). Liver Tumors. In: Tumors of the Fetus and Infant. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31620-3_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-31620-3_12
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31619-7
Online ISBN: 978-3-642-31620-3
eBook Packages: MedicineMedicine (R0)