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Direct Laser Writing of Neural Tissue Engineering Scaffolds for Biohybrid Devices

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Biomimetic and Biohybrid Systems (Living Machines 2012)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 7375))

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Abstract

In this study we explore the manufacture of polymer based, 3D structures for neuronal guidance made by direct laser writing (DLW). This technique enables the optimisation of the support structure via utilising Computer Aided Design and Manufacturing (CAD/CAM). The mechanical and chemical properties can be tuned via custom made polymer constructs. We present results on the polymer synthesis, DLW structuring, neuronal cell culture and guidance which provides a proof-of-concept for these scaffolds for use in peripheral neural biohybrid devices.

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References

  1. Melissinaki, V., Gill, A.A., Ortega, I., et al.: Direct laser writing of 3D scaffolds for neural tissue engineering applications (2011), doi:10.1088/1758-5082/3/4/045005

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  2. Jeon, H., Hidal, H., Hwang, D.J., et al.: The effect of micronscale anistropic cross patterns on fibroblast migration. Biomaterials 21(2010), 4286–4929 (2010)

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© 2012 Springer-Verlag Berlin Heidelberg

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Sherborne, C.R., Pateman, C.J., Claeyssens, F. (2012). Direct Laser Writing of Neural Tissue Engineering Scaffolds for Biohybrid Devices. In: Prescott, T.J., Lepora, N.F., Mura, A., Verschure, P.F.M.J. (eds) Biomimetic and Biohybrid Systems. Living Machines 2012. Lecture Notes in Computer Science(), vol 7375. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31525-1_57

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  • DOI: https://doi.org/10.1007/978-3-642-31525-1_57

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31524-4

  • Online ISBN: 978-3-642-31525-1

  • eBook Packages: Computer ScienceComputer Science (R0)

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