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Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants

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Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus

Part of the book series: SpringerBriefs in Animal Sciences ((BRIEFSANIMAL))

Abstract

There has been a substantial improvement in the detection of the nucleic acids of Peste des Petits Ruminants Virus (PPRV), and effective vaccines have been developed in recent years. Demonstrations of several real-time PCR assays have provided powerful and novel means of not only detection but also quantification of the nucleic acids of PPRV in several types of clinical samples. Although most of the lineages are continent specific, reports on mixed lineages are emerging, such as in Sudan and Uganda. None of the available assays is devised so far to differentiate all of the lineages. Despite essential advances in the marker vaccines, it is still required to establish reverse genetics systems to rescue recombinant PPRV vaccines, primarily by manipulating the genes of PPRV and insertion of positive or negative markers, which ultimately will lead to the development of companion test. Similarly, swapping different genes will facilitate the establishment of a test that can differentiate vaccinated and infected animals. In this chapter, we discuss available diagnostic tests and potent PPRV vaccines. Furthermore, the current advances in both fields and possibilities to develop next-generation assays and vaccines for PPRV are critically discussed.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Veterinary, Sciences (SLU), Swedish University of Agricultural, Ulls väg 2B, Uppsala, 751 89, Sweden

    Muhammad Munir

  2. Virology of SVA and SLU, Joint Research and Development Unit, Ulls väg 2B, Uppsala, 751 89, Sweden

    Siamak Zohari

  3. Department of Biomedical Sciences and Veterinary, Sciences (SLU), Swedish University of Agricultural, Ulls väg 2B, Uppsala, 751 89, Sweden

    Mikael Berg

Authors
  1. Muhammad Munir
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  2. Siamak Zohari
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  3. Mikael Berg
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Corresponding author

Correspondence to Muhammad Munir .

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Munir, M., Zohari, S., Berg, M. (2013). Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants. In: Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus. SpringerBriefs in Animal Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31451-3_6

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