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Immunology and Immunopathogenesis of Peste des Petits Ruminants Virus

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Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus

Part of the book series: SpringerBriefs in Animal Sciences ((BRIEFSANIMAL))

Abstract

Peste des Petits Ruminants Virus (PPRV) is highly immunosuppressive, but the host immune responses against vaccine and infection can mount an effective immunity to PPRV mediated by both cellular and humoral immunity. The T-and B-cell epitopes have been identified against nucleocapsid and hemagglutination-neuraminidase proteins, which provide a foundation for understanding the nature of immunity against PPRV and for the development of assays for epidemiology and surveillance. Based on these results, it is possible to establish the bases for strategies to differentiate infected versus vaccinated animals. There have been a number of reports demonstrating the induction of apoptosis by PPRV, immune suppression caused by PPRV, and cytokine responses against PPRV infection. The hematological and biochemical changes have been described in PPRV-infected animals, either experimentally, or naturally. In this chapter, all of these studies are reviewed and discussed.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Veterinary, Sciences (SLU), Swedish University of Agricultural, Ulls väg 2B, Uppsala, 751 89, Sweden

    Muhammad Munir

  2. Virology of SVA and SLU, Joint Research and Development Unit, Ulls väg 2B, Uppsala, 751 89, Sweden

    Siamak Zohari

  3. Department of Biomedical Sciences and Veterinary, Sciences (SLU), Swedish University of Agricultural, Ulls väg 2B, Uppsala, 751 89, Sweden

    Mikael Berg

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  1. Muhammad Munir
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  2. Siamak Zohari
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  3. Mikael Berg
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Correspondence to Muhammad Munir .

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Munir, M., Zohari, S., Berg, M. (2013). Immunology and Immunopathogenesis of Peste des Petits Ruminants Virus. In: Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus. SpringerBriefs in Animal Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31451-3_4

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