Prevention of Vascular Restenosis After Vascular Angioplasty

  • Wataro Tsuruta
  • Tetsuya Yamamoto
  • Akira Matsumura


Percutaneous transluminal angioplasty (PTA) and stenting are widely used methods for the treatment of vascular stenosis and much less invasive than surgery, but restenosis still occurs in 30–60 % of coronary artery cases, in no less than 5 % of carotid artery cases, and in 10–40 % of intracranial artery cases treated with PTA or stenting. Restenosis remains as the main limitation of vascular angioplasty, though the introduction of drug-eluting stents and brachytherapy has improved the restenosis rate. BNCT (boron neutron capture therapy) might be superior to beta or gamma-beam brachytherapy from the standpoint of normal structure injury, since the destructive effects of boron particles are limited to boron-containing cells. The possible application of BNCT for preventing restenosis after angioplasty was indicated in our preliminary study with a rat carotid artery model. Further investigation of the boron distribution in vascular and normal structures, development of appropriate boron compounds, and evaluation of the tolerability of BNCT for prevention of restenosis will be needed before BNCT can be applied clinically to prevent restenosis after stenting.


Boron Concentration Intimal Hyperplasia Carotid Artery Stenting Boron Neutron Capture Therapy Arterial Tissue 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Wataro Tsuruta
    • 1
  • Tetsuya Yamamoto
    • 2
  • Akira Matsumura
    • 1
  1. 1.Department of NeurosurgeryInstitute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of TsukubaTsukuba, IbarakiJapan
  2. 2.Department of Neurosurgery and Radiation OncologyInstitute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of TsukubaTsukubaJapan

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