Boron Neutron Capture Therapy for Children with Malignant Brain Tumors

Chapter

Abstract

Conventional radiation therapy for small children with malignant brain tumors might elongate the lifetime, but causes severe chronic neurocognitive effects and functional deficits. Boron neutron capture therapy (BNCT) can selectively destroy tumor cells with little damage to normal brain tissue, which promises good quality of life.

We studied the clinical outcome and courses in patients under 18 years old with malignant brain tumors. Among 183 patients with brain tumors treated by our group using BSH-based intraoperative BNCT, 29 patients were under 18 years. They included 11 patients less than 5 years. There were four glioblastomas (GBM), nine anaplastic astrocytomas (AAS), and seven primitive neuroectodermal tumors (PNET). Six patients had pontine gliomas, and one had anaplastic ependymoma. Seven out of 29 patients have lived more than 10 years after BNCT. Radiation necrosis was observed in only one patient, who suffered from hemiparesis and neurocognitive sequelae. The other patients had little damage caused by BNCT. BNCT can be applied to malignant brain tumors in children, especially those under 3 or 5 years of age, instead of conventional radiation therapy.

Keywords

Clinical Target Volume Neutron Beam Gross Tumor Volume Boron Concentration Normal Brain Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Mulhern KR et al (2004) Late neurocognitive sequelae in survivors of brain tumors in childhood. Lancet Oncol 15:399–408CrossRefGoogle Scholar
  2. 2.
    Hatanaka H, Nakagawa Y (1994) Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int J Radiat Oncol Biol Phys 28:1061–1066PubMedCrossRefGoogle Scholar
  3. 3.
    Nakagawa Y (1994) Boron neutron capture therapy: the past to the present. Int J Radiat Oncol Biol Phys 28:1217PubMedCrossRefGoogle Scholar
  4. 4.
    Nakagawa Y, Hatanaka H (1997) Boron neutron capture therapy-clinical brain tumor study. J Neurooncol 33:105–115PubMedCrossRefGoogle Scholar
  5. 5.
    Nakagawa Y et al (2003) Clinical review of Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams. J Neurooncol 62:87–99PubMedGoogle Scholar
  6. 6.
    Kageji T et al (2006) Boron neutron capture therapy using mixed epithermal and thermal neutron beams in patients with malignant glioma – correlation between radiation dose and radiation injury and clinical outcome-. Int J Radiat Oncol Biol Phys 65:1446–1455PubMedCrossRefGoogle Scholar
  7. 7.
    Kageji T et al (2006) Correlation between BNCT radiation dose and histopathological findings in BSH-based intra-operative BNCT for malignant glioma. Advances in Neutron Capture Therapy 2006:35–36Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of NeurosurgeryKagawa National Children’s HospitalKagawaJapan
  2. 2.Department of Neurosurgery, School of MedicineThe University of TokushimaTokushimaJapan

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