Boron Neutron Capture Therapy for Malignant Meningiomas

  • Shinji Kawabata
  • Shin-Ichi Miyatake


The management of malignant meningioma (MM) is very difficult. In a large series of patients with this tumor, the MM recurrence rate was reported to be 78–84 % within 5 years, and the median survival of patients 6.89 years. Late mortality due to recurrence was to be 69 % after the initial surgery. Although some treatments for recurrent MM have been reported, a standard treatment has not yet been developed.


Neutron Irradiation Gross Tumor Volume Boron Neutron Capture Therapy Local Tumor Progression Malignant Meningioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Brandsma D, Stalpers L, Taal W et al (2008) Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453–461PubMedCrossRefGoogle Scholar
  2. 2.
    Chamberlain MC, Glantz MJ, Chalmers L et al (2007) Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neurooncol 82:81–83PubMedCrossRefGoogle Scholar
  3. 3.
    Gonzalez J, Kumar AJ, Conrad CA et al (2007) Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 67:323–326PubMedCrossRefGoogle Scholar
  4. 4.
    Jaaskelainen J, Haltia M, Servo A (1986) Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 25:233–242PubMedCrossRefGoogle Scholar
  5. 5.
    Joensuu H, Kankaanranta L, Seppala T et al (2003) Boron neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine. J Neurooncol 62:123–134PubMedGoogle Scholar
  6. 6.
    Mahmood A, Caccamo DV, Tomecek FJ et al (1993) Atypical and malignant meningiomas: a clinicopathological review. Neurosurgery 33:955–963PubMedCrossRefGoogle Scholar
  7. 7.
    Miyatake SI, Kawabata S, Nonoguchi N et al (2009) Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas. Neuro Onocol 11(4):430–436CrossRefGoogle Scholar
  8. 8.
    Miyatake S, Kawabata S, Kajimoto Y et al (2005) Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages. J Neurosurg 103:1000–1009PubMedCrossRefGoogle Scholar
  9. 9.
    Miyatake S, Tamura Y, Kawabata S et al (2007) Boron neutron capture therapy for malignant tumors related to meningiomas. Neurosurgery 61:82–90, discussion − 1PubMedCrossRefGoogle Scholar
  10. 10.
    Miyatake S, Kawabata S, Yokoyama K et al (2009) Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas. J Neurooncol 91:199–206PubMedCrossRefGoogle Scholar
  11. 11.
    Ojemann SG, Sneed PK, Larson DA et al (2000) Radiosurgery for malignant meningioma: results in 22 patients. J Neurosurg 93(Suppl 3):62–67PubMedGoogle Scholar
  12. 12.
    Palma L, Celli P, Franco C et al (1997) Long-term prognosis for atypical and malignant ­meningiomas: a study of 71 surgical cases. J Neurosurg 86:793–800PubMedCrossRefGoogle Scholar
  13. 13.
    Salazar OM (1988) Ensuring local control in meningiomas. Int J Radiat Oncol Biol Phys 15:501–504PubMedCrossRefGoogle Scholar
  14. 14.
    Simpson D (1957) The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22–39PubMedCrossRefGoogle Scholar
  15. 15.
    Stenstam BH, Pellettieri L, Sorteberg W et al (2007) BNCT for recurrent intracranial meningeal tumours – case reports. Acta Neurol Scand 115:243–247PubMedCrossRefGoogle Scholar
  16. 16.
    Tamura Y, Miyatake S, Nonoguchi N et al (2006) Boron neutron capture therapy for recurrent malignant meningioma. Case report. J Neurosurg 105:898–903PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of NeurosurgeryOsaka Medical CollegeTakatsuki City, OsakaJapan

Personalised recommendations