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Neutron Capture Therapy pp 287–326Cite as

Treatment Planning

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Abstract

Treatment planning for neutron capture therapy (NCT) involves computation and analysis of the radiation dose distribution in a patient for determination of the neutron beam orientations and radiation fluence (monitor units) to enable delivery of an optimized radiation dose distribution that will comply with the dose prescription and optimize the dose to the target volume while respecting dose limits for normal tissues and organs at risk. Treatment planning for NCT differs markedly from treatment planning for photons or electrons in conventional radiotherapy and, in some ways, is significantly more complex. Unlike the treatment planning systems for conventional radiotherapy, NCT treatment planning systems exclusively rely on Monte Carlo simulation for dose calculations because of the complex, scatter-dominated nature of the radiation transport processes involved. This chapter discusses technical and clinical aspects of NCT treatment planning, including computational methods and the treatment planning process.

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Notes

  1. 1.

    The cadmium-differenced gold cross section is the difference between an unattenuated “bare” gold absorption cross section and the gold cross section attenuated by 0.439 g/cm2 cadmium.

  2. 2.

    Beam weight is most often taken to be proportional to beam monitor units, but other definitions, such as fraction of dose delivered to a point or structure, may also be used.

  3. 3.

    It is important to appreciate that the common assumption of static ratios between tissue and blood boron concentrations is only made for convenience of dosimetry and does not reflect the actual pharmacokinetics at all times, generally characterized by the dynamic tissue loading and washout observed in animal models [77] and in PET studies of humans using [18F]BPA-F [64, 65].

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Acknowledgments

The authors would like to thank Drs. C. Wojnecki and J.R. Albritton for helpful discussions, for critically reviewing the manuscript, and for assistance producing Fig. 16.2.

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Authors and Affiliations

  1. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Shapiro 505, Boston, MA, 02215, USA

    W. S. Kiger III

  2. Faculty of Medicine, Proton Medical Research Center, University of Tsukuba, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8576, Japan

    Hiroaki Kumada

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  1. Zentrum für Konservative Onkologie, Klinik für Strahlentherapie, Univ.Klinikum Essen, Hufelandstr. 55, Essen, 45122, Germany

    Wolfgang Sauerwein

  2. Philipps-University Marburg, Department of Radiation Oncology, University Hospital Marburg,, Baldingerstrasse 1, Marburg, 35043, Germany

    Andrea Wittig

  3. Joint Research Centre, Institute for Engergy, European Commission, Westerduinweg 3, LE Petten, 1755, Netherlands

    Raymond Moss

  4. , Department of Neurosurgery, Kagawa National Children's Hospital, Zentsuji-cho 2603, Zentsuji, 765-8501, Kagawa, Japan

    Yoshinobu Nakagawa

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Kiger, W.S., Kumada, H. (2012). Treatment Planning. In: Sauerwein, W., Wittig, A., Moss, R., Nakagawa, Y. (eds) Neutron Capture Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31334-9_16

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