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The Morphology of Microcalcifications in 2D Digital Mammography and Breast Tomosynthesis: Is It Different?

  • Eman Shaheen
  • Chantal Van Ongeval
  • Federica Zanca
  • Lesley Cockmartin
  • Nicholas Marshall
  • Frederik De Keyzer
  • Kenneth C. Young
  • David R. Dance
  • Hilde Bosmans
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7361)

Abstract

The development of new 3D imaging systems in the mammographic field is raising questions on its superiority of performance over 2D digital mammography in all aspects. Researchers are currently investigating the performance of digital breast tomosynthesis (DBT) compared to 2D digital mammography in terms of detectability of lesions (masses and microcalcifications) and diagnostic accuracy. Since a morphological description of the shape of microcalcifications is a determining factor for recalling the patient or not, we have investigated the efficiency of DBT in describing the morphology of microcalcifications within clusters compared to digital mammography. Four radiologists participated in the study and have described the shapes of microcalcifications in 71 clusters in 2D images and DBT series that were read in separate blinded sessions. An agreement test based on the kappa statistic was applied to evaluate the consistency of each reader’s evaluation in 2D and DBT. An inter-rater variability test was also applied for each modality. Results have shown that there is good agreement between the observers’ evaluations in these two modalities. The inter-rater test also revealed good agreement between the observers performance of assessment. In conclusion, this preliminary study has shown that the morphology of microcalcification clusters does not differ substantially in 2D versus DBT.

Keywords

Digital mammography breast tomosynthesis microcalcifications morphology of microcalcifications 

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References

  1. 1.
    Gennaro, G., et al.: Digital breast tomosynthesis versus digital mammography: a clinical performance study. Eur. Radiol. 20, 1545–1553 (2010)CrossRefGoogle Scholar
  2. 2.
    Andersson, I., Ikeda, D.M., Zackrisson, S., Ruschin, M., Svahn, T., Timberg, P., Tinberg, A.: Breast tomosynthesis and digital mammography: a comparison of breast cancer visibility and BIRADS classification in a population of cancers with subtle mammographic findings. Eur. Radiol. 18, 2817–2825 (2008)CrossRefGoogle Scholar
  3. 3.
    Spangler, M.L., et al.: Detection and classification of calcifications on digital breast tomosynthesis and 2D digital mammography: a comparison. Am. J. Roentgenol. 196, 320–324 (2011)CrossRefGoogle Scholar
  4. 4.
    Baker, R., Rogers, K.D., Shepherd, N., Stone, N.: New relationships between breast microcalcifications and cancer. Br. J. Cancer 103, 1034–1039 (2011)CrossRefGoogle Scholar
  5. 5.
    Picca, D.A., De Paredes, E.S.: Calcifications in the breast: a radiologic perspective. Appl. Radiol., 29–37 (September 2003)Google Scholar
  6. 6.
    Shaheen, E., Van Ongeval, C., Zanca, F., Cockmartin, L., Marshall, N., et al.: The Simulation of 3D Microcalcification Clusters in 2D Digital Mammography and Breast Tomosynthesis. Med. Phys. 38, 6659–6671 (2011)CrossRefGoogle Scholar
  7. 7.
    Mertelmeier, T., Orman, J., Haerer, W., Dudam, M.K.: Optimizing filtered backprojection reconstruction for a breast tomosynthesis prototype device. In: Proc. SPIE, vol. 6142, pp. 61420F1–61420F12 (2006)Google Scholar
  8. 8.
    Le Gal, M., Chavanne, G., Pellier, D.: Valeur diagnostique des microcalcifications groupees decouvertes par mammographies: a propos de 277 cas avec verification histologique et sans tumeur du sein palpable. Bull Cancer 71, 57–64 (1984)Google Scholar
  9. 9.
    American College of Radiology. Breast imaging reporting and data system (BIRADS). American College of Radiology, Reston (1993)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Eman Shaheen
    • 1
  • Chantal Van Ongeval
    • 1
  • Federica Zanca
    • 1
  • Lesley Cockmartin
    • 1
  • Nicholas Marshall
    • 1
  • Frederik De Keyzer
    • 1
  • Kenneth C. Young
    • 2
    • 3
  • David R. Dance
    • 2
    • 3
  • Hilde Bosmans
    • 1
  1. 1.Department of RadiologyUniversity Hospitals LeuvenLeuvenBelgium
  2. 2.Royal Surrey County HospitalNational Coordinating Centre for the Physics of MammographyGuildfordUnited Kingdom
  3. 3.Department of Physics, Faculty of Engineering and Physical SciencesUniversity of SurreyGuildfordUK

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