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Tumors and Tumor-Like Masses and Fistulas of the Neck

  • Georges L. Kaiser
Chapter

Abstract

The symptoms and signs that lead to medical consultation or further work-up examinations after careful clinical examination (often performed for other reasons) are a visible and/or palpable mass and/or fistula of the neck.

The history and precise clinical examination have a high significance for the differential diagnosis of these two leading signs. The midline or lateral location, the properties, and the history of the lesion (congenital or acquired) make it possible to assign them to a preliminary differential diagnosis as listed in Table 7.1 and to confirm it by additional examinations such as ultrasound, MRI/CT, fine needle aspiration, or fistulography.

Keywords

Thyroid Medullary Carcinoma Multinodular Goiter Follicular Adenoma Endemic Goiter Thyroglossal Duct Cyst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Bibliography

General: Textbooks, Differential Diagnosis

  1. Nicollas R, Guelfucci B, Roman S, Triglia JM (2000) Congenital cysts and fistulas of the neck. Int J Pediatr Otorhinolaryngol 55:117–124PubMedCrossRefGoogle Scholar
  2. Smith CD (1998) Cysts and sinuses of the neck. In: O’Neill JA Jr et al (eds) Pediatric surgery, vol I, 5th edn. Mosby, St LouisGoogle Scholar

Section 7.1.1

  1. Horisawa M et al (1991) Anatomical reconstruction of the thyroglossal duct. J Pediatr Surg 26:766–769PubMedCrossRefGoogle Scholar
  2. Perez-Martinez A, Bento-Bravo L, Martinez-Bermejo MA, Conde-Cortes J, de Miguel-Medina C (2005) An intra-thyroid thyroglossal duct cyst. Eur J Pediatr Surg 15:428–430PubMedCrossRefGoogle Scholar

Section 7.1.3

  1. Cochran CS, DeFatta RJ, Brenski AC (2006) Congenital midline cervical cleft: a practical approach to Z-plasty closure. Int J Pediatr Otorhinolaryngol 70:553–559PubMedCrossRefGoogle Scholar
  2. Mendis D, Moss AL (2007) Case series: variations in the embryology of congenital midline cervical clefts. Acta Chir Plast 49:71–74PubMedGoogle Scholar

Section 7.1.4

  1. Bale PM, Sotelo-Avila C (1993) Maldescent of the thymus: 34 necropsy and 10 surgical cases, including 7 thymuses medial to the mandible. Pediatr Pathol 13:181–190PubMedCrossRefGoogle Scholar
  2. Büyükyavuzi OS, Karnaki I, Akcören Z, Senocak ME (2002) Ectopic thymic tissue as a rare and confusing entity. Eur J Pediatr Surg 12:327–329CrossRefGoogle Scholar
  3. Cigliano B, Baltogiannis N, De Marco M, Faviou E, Antoniou D, De Luca U, Soutis M, Settimi A (2007) Cervical thymic cysts. Pediatr Surg Int 23:1219–1225PubMedCrossRefGoogle Scholar
  4. Statham MM, Mehta D, Wilging JP (2008) Cervical thymic remnants in children. Int J Pediatr Otorhinolaryngol 72:1807–1813PubMedCrossRefGoogle Scholar

Section 7.1.5

  1. Elmasalme F, Giacomastonio M, Clarke KD, Othman L, Matbouli S (2000) Congenital cervical teratoma in neonates. Case report and review. Eur J Pediatr Surg 10:252–257PubMedCrossRefGoogle Scholar

Section 7.2.1

  1. Almeida MQ, Stratakis CA (2010) Solid tumors associated with multiple endocrine neoplasias. Cancer Genet Cytogenet 203:30–36PubMedCrossRefGoogle Scholar
  2. Ardito G, Pintus C, Revelli L, Grottesi A, Modugno C, Vincenzoni C, Fadda G, Perrelli L (2001) Thyroid tumors in children and adolescents: preoperative study. Eur J Pediatr Surg 11:154–157PubMedCrossRefGoogle Scholar
  3. Bingöl-Kologlu M, Tanyel FC, Senocak ME, Büyükpamukcu N, Hicsönmez A (2000) Surgical treatment of differentiated thyroid carcinoma in children. Eur J Pediatr Surg 10:347–352PubMedGoogle Scholar
  4. Fitze G (2004) Management of patients with hereditary medullary thyroid carcinoma. Eur J Pediatr Surg 14:375–383PubMedCrossRefGoogle Scholar
  5. Monte O, Calliari LE, Kochi C, Scalisse NM, Marone M, Longui CA (2007) Thyroid carcinoma in children and adolescents. Arq Bras Endocrinol Metabol 51:763–768PubMedCrossRefGoogle Scholar
  6. Thompson NW, Geiger JD (1998) Thyroid/parathyroid. In: O’Neill JA Jr (ed) Pediatric surgery, vol I, 5th edn. Mosby, St LouisGoogle Scholar

Section 7.2.2

  1. Biertho LD, Kim C, Wu HS, Unger P, Inabnet WB (2004) Relationship between sestamibi uptake, parathyroid hormone assay; and nuclear morphology in primary hyperparathyroidism. J Am Coll Surg 199:229–233PubMedCrossRefGoogle Scholar
  2. Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ (2005) Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 257:6–17PubMedCrossRefGoogle Scholar
  3. Kollars J, Zarroung AE, van Heerden J et al (2005) Primary hyperparathyroidism in pediatric patients. Pediatrics 115:974–980PubMedCrossRefGoogle Scholar
  4. Kurmann A, Schmassmann A, Wildisen A (2006) Pesistierender primärer hyperparathyroidismus und rezidivierende pankreatitis nach der resection eines parathyroi-dea-adenomas (persistent primary hyperparathyroidism and recurrent pancreatitis after resection of a parathyroid adenoma). Schweiz Med Forum 6:1134–1136Google Scholar
  5. Peacock M, Bilezikian JP, Preston S, Klassen PS, Matthew DG, Turner SA et al (2005) Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab 90:135–141PubMedCrossRefGoogle Scholar
  6. Schweizer I, Meili A, Gemsenjäger E (2005) Kropfknoten mit Polyarthralgie und Myalgie (thyroid node accompanied by polyarthralgia and myalgia). Schweiz Med Forum 5:882–884Google Scholar

Section 7.3.1–7.3.2

  1. Chen Z, Wang Z, Dai C (2010) An effective surgical technique for excision of first branchial cleft fistulas: make-inside-exposed method by tract incision. Eur Arch Otorhinolaryngol 267:267–271PubMedCrossRefGoogle Scholar
  2. Mantle BA, Otteson TD, Chi DH (2008) Fourth branchial cleft sinus: relationship to superior and ­recurrent laryngeal nerves. Am J Otolaryngol 29:198–200PubMedCrossRefGoogle Scholar
  3. Martinez DelPero M, Majumdar S, Bateman N, Bull PD (2007) Presentation of first branchial cleft anomalies: the Sheffield experience. J Laryngol Otol 121:455–459Google Scholar
  4. Neff L, Kirse D, Pranikoff T (2009) An unusual presentation of a fourth pharyngeal arch (branchial cleft) sinus. J Pediatr Surg 44:626–629PubMedCrossRefGoogle Scholar
  5. Schroeder JW Jr, Mohyuddin N, Maddalozzo J (2007) Branchial anomalies in the pediatric population. Otolaryngol Head Neck Surg 137:289–295PubMedCrossRefGoogle Scholar
  6. Shrime M, Kacker A, Bent J, Ward RF (2003) Fourth branchial complex anomalies: a case series. Int J Pediatr Otorhinolaryngol 67:1227–1233PubMedCrossRefGoogle Scholar
  7. Smith SL, Pereira KD (2008) Suppurative thyroiditis in children: a management algorithm. Pediatr Emerg Care 24:764–767PubMedCrossRefGoogle Scholar
  8. Stenquist M, Juhlin C, Aström G, Friberg U (2003) Fourth branchial pouch sinus with recurrent deep cervical abscesses successfully treated with trichloroacetic acid cauterization. Acta Otolaryngol 123:879–882PubMedGoogle Scholar
  9. Tham YS, Low WK (2005) First branchial cleft anomalies have relevance in otology and more. Ann Acad Med Singapore 34:335–338PubMedGoogle Scholar

Section 7.3.4

  1. Banieghbal B, Davies MRQ (2003) Guidelines for the successful treatment of lymphangioma with OK-432. Eur J Pediatr Surg 13:103–107PubMedCrossRefGoogle Scholar
  2. Bekker MN, van den Akker NM, de Mooij YM, Bartelings MM, van Vugt JM, Gitten berger-de Groot AC (2008) Jugular lymphatic maldevelopment in turner syndrome and trisomy 21: different anomalies leading to nuchal edema. Reprod Sci 15:295–304PubMedCrossRefGoogle Scholar
  3. DiLorenzo M, Yazbeck S (1998) Lymphangiomas. In: Stringer MD et al (eds) Pediatric surgery and urology: long term outcomes. Saunders, LondonGoogle Scholar
  4. Gedikbasi A, Gul A, Sargin A, Ceylan Y (2007) Cystic hygroma and lymphangioma: associated findings, perinatal outcome and prognostic factors in live-born infants. Arch Gynecol Obstet 276:491–498PubMedCrossRefGoogle Scholar
  5. Graesslin O, Derniaux E, Alanio E, Gaillard D, Vitry F, Quéreux C, Ducarme G (2007) Characteristics and outcome of fetal hygroma diagnosed in the first trimester. Acta Obstet Gynecol Scand 86:1442–1446PubMedCrossRefGoogle Scholar
  6. Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children. A classification based on endothelial characteristics. Plast Reconstr Surg 69:412–420PubMedCrossRefGoogle Scholar
  7. Okazaki T, Iwatani S, Yanai T, Kobayashi H, Kato Y, Marusasa T, Lane GJ, Yamataka A (2007) Treatment of lymphangioma in children: our experience of 128 cases. J Pediatr Surg 42:386–389PubMedCrossRefGoogle Scholar
  8. Schuster T, Grantzow R, Nicolai T (2003) Lymphangioma colli – a new classification contributing to prognosis. Eur J Pediatr Surg 13:97–102PubMedCrossRefGoogle Scholar

Section 7.3.5

  1. Chavez Delgado ME, Castro Castaneda S, Ramirez Jaime GC, de la Rosa AC, Real Choi SJ, Choung YH, Park K, Bae J, Park HY (2007) The variant type of preauricular sinus: postauricular sinus. Laryngoscope 117:1798–1802CrossRefGoogle Scholar
  2. Gohary A, Rangecroft L, Cook RC (1983) Congenital auricular and preauricular sinuses in childhood. Z Kinderchir 38:81–82PubMedGoogle Scholar
  3. Kugelman A, Tubi A, Bader D et al (2002) Pre-auricular tags and pits in the newborn: the role of renal ultrasonography. J Pediatr 141:388–391PubMedCrossRefGoogle Scholar
  4. Marquez E, Gonzalez Fuentes VM (2008) Surgical management and recurrence of congenital preauricular fistula. Cir Pediatr 21:73–78Google Scholar
  5. Yeo SW, Jun BC, Park SN, Lee JH, Song CE, Chang KH, Lee DH (2006) The preauricular sinus: factors contributing to recurrence after surgery. Am J Otolaryngol 27:396–400PubMedCrossRefGoogle Scholar

Section 7.3.6

  1. Cardin P, Orbach D (2010) Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery. Int J Pediatr Otorhinolaryngol 74:942–945PubMedCrossRefGoogle Scholar
  2. Marucci DD, Lawson K, Harper J, Sebire NJ, Dunaway DJ (2009) Sialoblastoma arising in ectopic salivary gland tissues. J Plast Reconstr Aesthet Surg 62:e241–e246PubMedCrossRefGoogle Scholar
  3. Mortellaro C, Dall’Oca S, Lucchina AG, Castiglia A, Farronato G, Fenini E, Marenzi G, Trosino O, Cafiero C, Sammartino G (2008) Sublingual ranula: a closer look to its surgical management. J Craniofac Surg 19:286–290PubMedCrossRefGoogle Scholar
  4. Patel MR, Deal AM, Shockley WW (2009) Oval and plunging ranulas: what is the most effective treatment. Laryngoscope 119:1501–1509PubMedCrossRefGoogle Scholar
  5. Scott JX, Krishnan S, Bourne AJ, Williams MP, Agzarian M, Revesz T (2008) Treatment of metastatic sialoblastoma with chemotherapy and surgery. Pediatr Blood Cancer 50:134–137PubMedCrossRefGoogle Scholar
  6. Williams SB, Ellis GL, Warnock GR (2006) Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol 10:320–326PubMedCrossRefGoogle Scholar

Differential Diagnosis Congenital Neck Tumors

  1. Challapalli A, Howell L, Farrier M, Kelsey A, Birch J, Eden T (2007) Cervical paraganglioma – a case report and review of all cases reported to the Manchester Children’s tumour registry 1954-2004. Pediatr Blood Cancer 48:112–116PubMedCrossRefGoogle Scholar
  2. Manolidis S, Higuera S, Boyd V, Hollier LH (2006) Single-stage total and near-total resection of massive pediatric head and neck neurofibromas. J Craniofac Surg 17:506–510PubMedCrossRefGoogle Scholar
  3. Ustundag E, Iseri M, Keskin G, Yayla B, Muezzinoglu B (2005) Cervical bronchogenic cysts in the head and neck region. J Laryngol Otol 119:419–423PubMedCrossRefGoogle Scholar

Section 7.4.1–7.4.3

  1. Ellis J, Oyston PC, Green M, Titball RW (2002) Tularemia. Clin Microbiol Rev 15:631–646PubMedCrossRefGoogle Scholar
  2. Leventhal BG, Donaldson SS (1993) Hodgkin’s disease. In: Pizzo PA, Poplack DC (eds) Principles and practice of pediatric oncology. Lippincott, PhiladelphiaGoogle Scholar
  3. Margrath IT (1993) Malignant non-Hodgkin’s lymphoma in children. In: Pizzo PA, Poplack DC (eds) Principles and practice of pediatric oncology. Lippincott, PhiladelphiaGoogle Scholar
  4. Newman KD, Sato TT (1998) Lymph node disorders. In: O’Neill JA et al (eds) Pediatric surgery, vol I, 5th edn. Mosby, St LouisGoogle Scholar
  5. Piedimonte G, Wolford ET, Fordham LA et al (1997) Mediastinal lymphadenopathy caused by mycobacterium avium-intracellulare complex in a child with normal immunity: successful treatment anti-mycobacterial drugs and laser bronchoscopy. Pediatr Pulmonol 24:287–291PubMedCrossRefGoogle Scholar
  6. Pranghofer S, Rossi M, Uebelhart T (2004) Tularämie bei Lymphknotenschwellung – Differentialdiagnose der Vergangengenheit? Schweiz Med Forum 4:567–569Google Scholar
  7. Shah JP et al (1993) Cervical lymph node metastasis. Curr Probl Surg 30:273–335CrossRefGoogle Scholar

Section 7.4.4–7.4.5

  1. Bentz BG, Hughes CA, Lüdemann JP, Maddalozzo J (2000) Masses of the salivary gland region in children. Arch Otolaryngol Head Neck Surg 126:1435–1439PubMedGoogle Scholar
  2. Fraser GC (1998) Salivary glands. In: O’Neill JA Jr et al (eds) Pediatric surgery, vol I, 5th edn. Mosby, St LouisGoogle Scholar
  3. Greene AK, Rogers GF, Mulliken JB (2004) Management of parotid hemangioma in 100 children. Plast Reconstr Surg 113:53–60PubMedCrossRefGoogle Scholar
  4. Marchal F, Dulguerov P (2003) Sialolithiasis management: the state of the art. Arch Otolaryngol Head Neck Surg 129:951–956PubMedCrossRefGoogle Scholar
  5. Orvidas LJ, Kasperbauer JL, Lewis JE, Olsen KD, Lesnick TB (2000) Pediatric parotid masses. Arch Otolaryngol Head Neck Surg 126:177–184PubMedGoogle Scholar
  6. Prigent M, Teissier N, Peuchmaur M, El-Maleh-Berges M, Philippe-Chomette P, Wolfensberger M (2003) ORL, Hals- und Gesichtschirurgie: Das Endoskop erobert die Speicheldrüse. Schweiz Med Forum 51(52):1269–1272Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Georges L. Kaiser
    • 1
  1. 1.Department of Pediatric Surgery InselspitalUniversity of BerneBerneSwitzerland

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