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Animal Studies in Deep Brain Stimulation Research

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Deep Brain Stimulation

Abstract

The main goal of deep brain stimulation (DBS) research is to offer a better insight into the mechanism of action of DBS. In addition, it is also necessary to provide an experimental basis for new therapeutic applications, for novel targets, and for optimizing stimulation parameters in psychiatric disorders. This chapter provides a description of the essential advantages of animal research to achieve these goals. In addition, we discuss the limitations of animal research and suggest that a fruitful approach is offered by a careful selection of disease-independent neurobehavioral domains, for which translational methods are available. Two examples of such domains, anxiety and reward processing, are presented.

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Author information

Authors and Affiliations

  1. Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands

    Matthijs G. P. Feenstra & Damiaan Denys

  2. Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Matthijs G. P. Feenstra & Damiaan Denys

Authors
  1. Matthijs G. P. Feenstra
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  2. Damiaan Denys
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Corresponding author

Correspondence to Matthijs G. P. Feenstra .

Editor information

Editors and Affiliations

  1. , Department of Psychiatry, Academic Medical Center, University of A, PO Box 75867, Amsterdam, 1070 AW, Netherlands

    Damiaan Denys

  2. , Neuromodulation and Behaviour, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105 BA, Netherlands

    Matthijs Feenstra

  3. , Department of Neurosurger, Academic Medical Center, University of A, Meibergdreef 9, Amsterdam, 1070 AW, Netherlands

    Rick Schuurman

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© 2012 Springer-Verlag Berlin Heidelberg

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Feenstra, M.G.P., Denys, D. (2012). Animal Studies in Deep Brain Stimulation Research. In: Denys, D., Feenstra, M., Schuurman, R. (eds) Deep Brain Stimulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30991-5_20

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