Multi-scale Modeling of Gene Regulation of Morphogenesis

  • Jaap A. Kaandorp
  • Daniel Botman
  • Carlos Tamulonis
  • Roland Dries
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7318)


In this paper we demonstrate a spatio-temporal gene regulatory network for early gastrulation in the sea anemone Nematostella vectensis. We measure gene expression during early gastrulation using a gene expression quantification tool. We measure gene expression during early gastrulation when the embryo is more or less radial symmetrical and where there is only one body axis (the aboral - oral body axis in the case of Nematostella), allowing us, to use a one-dimensional model. The shape changes are induced by mechanical forces that are defined as rules or explicitly coupled to genetic regulation. The morphological evolution of the Nematostella embryo during gastrulation is described by a cell-based model, which can potentially be coupled with the one-dimensional gene regulatory network.


Gene Regulatory Network Measure Gene Expression Snail Expression Blastula Stage Apical Constriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jaap A. Kaandorp
    • 1
  • Daniel Botman
    • 1
  • Carlos Tamulonis
    • 1
  • Roland Dries
    • 1
  1. 1.Faculty of SciencesUniversiteit van AmsterdamAmsterdamThe Netherlands

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