Matrix Mechanics and Cell Contractility in Angiogenesis

  • Joseph P. Califano
  • Cynthia A. Reinhart-King
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 12)


Angiogenesis is a complex process that relies on the interplay of chemical and mechanical signaling events that ultimately result in the formation of new blood vessels. While much work has uncovered the chemical signaling events that mediate angiogenesis, the role of the mechanical environment is less understood. In this chapter, we will discuss how the mechanical microenvironment regulates angiogenesis by examining how matrix stiffness and cellular contractility mediate endothelial cell behaviors that are necessary for the progression of angiogenesis. Specifically, we will describe the roles of matrix stiffness and cell contractility as regulators of endothelial cell adhesion and shape, migration, growth, cell–cell interactions, and cell–matrix remodeling. Collectively, these findings implicate endogenous cellular forces and matrix stiffness as critical components of the angiogenic microenvironment, and suggest that both are important parameters for tissue engineering applications and a greater understanding of angiogenesis during disease progression.


Matrix Stiffness Traction Force Actin Stress Fiber Cell Contractility Ligand Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Joseph P. Califano
    • 1
  • Cynthia A. Reinhart-King
    • 1
  1. 1.Department of Biomedical EngineeringCornell University 302 Weill HallIthacaUSA

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