Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction

  • Devon Scott
  • Wei Tan
  • Jerry S. H. Lee
  • Owen J. T. McCarty
  • Monica T. Hinds
Chapter
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 12)

Abstract

Whether examined at the micro- or macroscale, biological phenomenona are not exempt from physical laws and principles. The vasculature is frequently utilized as a model system to better understand and analyze the consequences of biophysical forces on biochemical processes and ultimate biological phenotypes. Given the complexities of biological systems, there is an inherent need to focus in order to properly elucidate mechanisms. Mechanotransduction and cell mechanics in various stages of angiogenesis have long been examined at distinct length-scales ranging from subcellular, cellular, multi-cellular, tissue, and beyond. This chapter will highlight research over the past decades that have contributed to revealing the importance and interplay between biophysical forces (compressive and shear flow) and biological behavior (motility, regulation of smooth muscle cells, polarity). Abnormal biophysical forces, such as hypertension, contribute significantly to vascular diseases, including atherosclerosis and aneurysm formation. Understanding the relationship between biophysical forces and biological behavior is required to understand the mechanisms of vascular disease.

Keywords

Pulmonary Hypertension Pulse Pressure Focal Adhesion Arterial Stiffness Pulsatile Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by the American Heart Association 09BGIA2260384 (M.T.H), and the National Institute of Health grants 1R01HL103728 (M.T.H.), R01HL101972 (O.J.T.M.) and 1U54CA143906 (O.J.T.M.).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Devon Scott
    • 1
  • Wei Tan
    • 2
  • Jerry S. H. Lee
    • 3
    • 4
  • Owen J. T. McCarty
    • 1
  • Monica T. Hinds
    • 1
  1. 1.Department of Biomedical EngineeringOregon Health and Science UniversityPortlandUSA
  2. 2.Department of Mechanical EngineeringUniversity of Colorado at BoulderBoulderUSA
  3. 3.Department of Chemical and Biomolecular EngineeringJohns Hopkins UniversityBaltimoreUSA
  4. 4.Center for Strategic Scientific InitiativesNational Cancer InstituteBethesdaUSA

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