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Microfluidic Devices for Angiogenesis

  • Vernella Vickerman
  • Choong Kim
  • Roger D. Kamm
Chapter
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 12)

Abstract

Cell culture has played a central role in developing our understanding of angiogenesis, and a wide variety of culture systems have been adapted for this purpose. Despite the value of this approach, many of the systems employed have suffered from a lack of precise control over culture conditions, an inability to visualize the process of angiogenesis in real time, and limitations in the ability to replicate the in vivo situation in which multiple cell types interact over distances of 100s of microns. With the advent of microfluidics, many of these obstacles can be overcome, and in vitro experiments can be produced with closer relevance to the in vivo situation. In this chapter, we describe the evolution of these microfluidic devices in the context of angiogenesis and describe current capabilities.

Keywords

Microfluidic Device Vascular Network Microfluidic System Fluid Shear Stress Multiple Cell Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to acknowledge support from the NIBIB, the National Science Foundation (EFRI-0735997 and CBET-0939511), and the Singapore-MIT Alliance for Research and Technology.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Vernella Vickerman
    • 1
  • Choong Kim
    • 1
  • Roger D. Kamm
    • 1
  1. 1.Mechanical Engineering and Biological Engineering, MITCambridgeUSA

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