Reactive Oxygen Species in Physiologic and Pathologic Angiogenesis

Chapter
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 12)

Abstract

Reactive oxygen species (ROS), including superoxide and hydrogen peroxide, play a major role in angiogenesis. High ROS doses induce oxidative stress and subsequent cell death in a variety of cardiovascular diseases, including hypertension and atherosclerosis. However, low doses of externally applied ROS directly promote angiogenesis by causing sub-lethal cell membrane damage and subsequent fibroblast growth factor-2 release, by increasing growth factor production, or by enhancing growth factor binding to their receptors. Once angiogenic growth factor signaling is initiated, ROS are produced intracellularly through NAD(P)H oxidases and manganese superoxide dismutase as messengers in downstream growth factor signaling for proliferation, migration, and tube formation. This chapter discusses our current understanding of the vascular ROS balance in both physiologic and pathologic angiogenesis, as well as innovative approaches to applying ROS to induce angiogenesis.

Keywords

Reactive Oxygen Species Vascular Endothelial Growth Factor NADPH Oxidase Vascular Endothelial Growth Factor Expression Dielectric Barrier Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Mechanical Engineering and MechanicsDrexel UniversityPhiladelphiaUSA

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