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How Do Production Systems in Biological Cells Maintain Their Function in Changing Environments?

  • Moritz Emanuel BeberEmail author
  • Marc-Thorsten Hütt
Conference paper
Part of the Lecture Notes in Production Engineering book series (LNPE)

Abstract

Metabolism is a fascinating natural production and distribution process. Metabolic systems can be represented as a layered network, where the input layer consists of all the nutrients in the environment (raw materials entering the production process in the cell), subsequently to be processed by a complex network of biochemical reactions (middle layer) and leading to a well-defined output pattern, optimizing, e.g., cell growth. Mathematical frameworks exploiting this layered-network representation of metabolism allow the prediction of metabolic fluxes (the cell’s ’material flow’) under diverse conditions. In combination with suitable minimal models it is possible to identify fundamental design principles and understand the efficiency and robustness of metabolic systems. Here, we summarize some design principles of metabolic systems from the perspective of production logistics and explore, how these principles can serve as templates for the design of robust manufacturing systems.

Keywords

Systems biology Metabolic networks Enzymes Design principles Simulated evolution 

Notes

Acknowledgments

MEB is supported by a Deutsche Forschungsgemeinschaft grant to MTH (grant HU-937/6). We are indebted to Nikolaus Sonnenschein (San Diego, USA) for providing his expertise on flux-balance analysis. We gratefully acknowledge discussions and close collaboration with Katja Windt (Bremen, Germany) on the parallels of metabolism and manufacturing.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.School of Engineering and ScienceJacobs UniversityBremenGermany

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