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A Scalable Feature Selection Method to Improve the Analysis of Microarrays

  • Aida de Haro-García
  • Javier Pérez-Rodríguez
  • Nicolás García-Pedrajas
Conference paper
Part of the Studies in Computational Intelligence book series (SCI, volume 431)

Abstract

DNA microarray experiments are used to collect information from tissue and cell samples regarding gene expression differences that are useful for diagnosis and treatment of many different diseases. The predictive accuracy is hindered by the large dimensionality of these datasets and the existence of irrelevant and redundant features. The performance of a feature selection process could improve the classification accuracy of this demanding research field.

However, standard feature selection method performance may be very poor in high-dimensional microarray data. We propose a scalable evolutionary method to select relevant genes. We use a divide-and-conquer approach to deal with the scalability issues of the evolutionary algorithms, and a combination of different rounds of feature selection to increase the accuracy results and storage reduction. Our proposal improves the results of standard classifiers and feature selection methods in accuracy and storage reduction for 8 different microarray datasets.

Keywords

Genetic Algorithm Feature Selection Feature Selection Method Microarray Dataset Feature Selection Algorithm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Aida de Haro-García
    • 1
  • Javier Pérez-Rodríguez
    • 1
  • Nicolás García-Pedrajas
    • 1
  1. 1.Department of Computing and Numerical AnalysisUniversity of CórdobaCórdobaSpain

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