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Sex and Gender Differences in Pharmacology pp 523–542Cite as

Gender Differences in Anticoagulation and Antithrombotic Therapy

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 214))

Abstract

Cardiovascular disease is the main cause of mortality and morbidity worldwide. The rate of thromboembolic events has increased in women but not in men. Large clinical studies support the use of a variety of antithrombotic drugs for the treatment of patients with different cardiovascular diseases. The heterogeneous patient population included in these trials affects the attempt to generalize the study results to subgroups, which are not sufficiently represented in the study population, such as women and other minorities. Gender-related differences in the clinical presentation and outcome seem to relate to differences in platelet biology and coagulation reactions, resulting in different rates of thromboembolic and bleeding events. The effectiveness of antithrombotic therapies and the occurrence of adverse events define the clinical benefit of the treatment for each patient. This chapter gives an overview of the currently available data on gender-differences in anticoagulation and antithrombotic therapy.

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Abbreviations

ACS:

Acute coronary syndrome

AF:

Atrial fibrillation

INR:

International normalized ratio

MI:

Myocardial infarction

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  1. Medical Clinic II—Cardiology and Pulmonology, Campus Benjamin Franklin, Charité–Universitätsmedizin Berlin, Berlin, Germany

    Ursula Rauch

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  1. Ursula Rauch
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Correspondence to Ursula Rauch .

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  1. Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, Berlin, 10115, Germany

    Vera Regitz-Zagrosek

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Rauch, U. (2013). Gender Differences in Anticoagulation and Antithrombotic Therapy. In: Regitz-Zagrosek, V. (eds) Sex and Gender Differences in Pharmacology. Handbook of Experimental Pharmacology, vol 214. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30726-3_23

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