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Sex Differences in Effects and Use of Anti-inflammatory Drugs

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Sex and Gender Differences in Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 214))

Abstract

Gender accounts for important differences in the incidence, prevalence, and course of many immunoinflammatory diseases. However, similar treatment strategies, such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor-α (TNF-α) inhibitors, have been advocated for both genders. Experimental studies found that molecular mechanisms of inflammation differ in males and females. In our chapter we summarize the data concerning gender-specific aspects about prevalence of use, drug survival, responsiveness, and adverse drug effects of NSAIDs and TNF-α inhibitors. Gender-related differences in the prevalence and course of many autoimmune diseases as well as differences in effects of anti-inflammatory drugs should be considered for the tailored treatment options for these patients.

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Abbreviations

COX:

Cyclooxygenase

ERK:

Extracellular signal-regulated kinase

FDA:

Food and Drug Administration

IFN:

Interferon

IL:

Interleukin

IL-1Ra:

IL-1 receptor antagonist

NF-κB:

Nuclear factor-κB

NSAIDs:

Nonsteroidal anti-inflammatory drugs

RA:

Rheumatoid arthritis

TNF-α:

Tumor necrosis factor-α

UGIB:

Upper gastrointestinal bleeding

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Demyanets, S., Wojta, J. (2013). Sex Differences in Effects and Use of Anti-inflammatory Drugs. In: Regitz-Zagrosek, V. (eds) Sex and Gender Differences in Pharmacology. Handbook of Experimental Pharmacology, vol 214. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30726-3_20

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