Atlas-Based Segmentation of the Subthalamic Nucleus, Red Nucleus, and Substantia Nigra for Deep Brain Stimulation by Incorporating Multiple MRI Contrasts
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for drug-resistant Parkinson’s disease (PD). Pre-operative identification of the STN is an important step for this neurosurgical procedure, but is very challenging because of the accuracy necessary to stimulate only a sub-region of the small STN to achieve the maximum therapeutic benefits without serious side effects. Previously, a technique that automatically identified basal ganglia structures was proposed by registering a 3D histological atlas to a subject’s anatomy shown in the T1w MRI image. In this paper, we improve the accuracy of this technique for the segmentation of the STN, substantia nigra (SN), and red nucleus (RN). This is achieved by using additional MRI contrasts (i.e. T2*w and T2w images) that can better visualize these nuclei compared to the sole T1w contrast used previously. Through validation using the silver standard ground truth obtained for 6 subjects (3 healthy and 3 PD), we observe significant improvements for segmenting the STN, SN, and RN with the new technique when compared to the previous method that only uses T1w-T1w inter-subject registration.
KeywordsSubstantia Nigra Deep Brain Stimulation Fusion Image Subthalamic Nucleus Segmentation Performance
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- 11.Xiao, Y., Beriault, S., Pike, B.G., Collins, D.L.: Multi-contrast multi-echo FLASH MRI for targeting the subthalamic nucleus. Magn. Reson. Imaging (to appear)Google Scholar