• Hylde Zirpoli
  • Mariella Caputo
  • Mario F. Tecce


The entire complex of molecular processes of the human organism results from endogenous physiological execution of the information encoded in the genome but is also influenced by exogenous factors, which include those originating from nutrition as major agents. The assimilation of nutrient molecules within the human body continuously allows homeostatic reconstitution of its qualitative and quantitative composition but also takes part in physiological changes of body growth and adaptation to particular situations. Nevertheless, in addition to replacing material and energetic losses, nutritional intake also provides bioactive molecules, which are selectively able to modulate specific metabolic pathways, noticeably affecting the risk of cardiovascular and neoplastic diseases, which are the major cause of mortality in developed countries. Numerous bioactive nutrients are being progressively identified and their chemopreventive effects are being described at clinical and molecular mechanism levels. All omics technologies (such as transcriptomics, proteomics, and metabolomics) allow systematic analyses to study the effect of dietary bioactive molecules on the totality of molecular processes.

Since each nutrient might also have specific effects on individually different genomes, nutrigenomic and nutrigenetic analysis data can be distinguished by two different observational views: 1) the effects of the whole diet and of specific nutrients on genes, proteins, metabolic pathways, and metabolites; and 2) the effects of specific individual genomes on the biological activity of nutritional intake and of specific nutrients. Nutrigenomic knowledge of physiologic status and disease risk will provide the development of better diagnostic procedures as well as new therapeutic strategies specifically targeted to nutritionally relevant processes.


Nuclear Magnetic Resonance Spectroscopy Nutritional Intake System Biology Markup Language Diallyl Disulfide Omics Technology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





biological networks gene ontology


capillary electrophoresis


complexpathway simulator


chromatin immunoprecipitation


coenzyme A


docosahexaenoic acid


deoxyribonucleic acid


eicosapentaenoic acid


extracellular signal-regulated kinase


Fourier-transform ion cyclotron resonance


Fourier transform infrared


Fourier transform


gas chromatography–mass spectrometry


Granger causality


gene ontology




high-oleic acid sunflower oil


high-performance liquid chromatography


ion-cyclotron resonance Fourier transform


ion cyclotron resonance


liquid chromatography-mass spectrometry


liquid chromatography


low-calorie diet


matrix assisted laser desorption/ionization


mass spectrometry


multidimensional protein identification technology


nuclear magnetic resonance


ordinary differential equation


peripheral blood mononuclear cell


polymerase chain reaction




peroxisome proliferator-activated receptor-α


polyunsaturated fatty acid


ribonucleic acid


Systems Biology Graphical Notation


systems biology markup language


single-nucleotide polymorphism


systems biology workbench






ultra-performance liquid chromatography


complementary DNA


complementary RNA


messenger RNA




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Copyright information

© Springer-Verlag 2014

Authors and Affiliations

  1. 1.Dipartimento di FarmaciaUniversità di SalernoFiscianoItaly
  2. 2.Dipartimento di FarmaciaUniversità di SalernoFiscianoItaly
  3. 3.Dipartimento di FarmaciaUniversità di SalernoFiscianoItaly

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