Follicular Atresia as a Proliferative and Inflammatory Event

  • Katharina Spanel-Borowski
Chapter

Abstract

Follicular atresia is more than a process of involution. It is also a proliferative event showing granulosa cells in mitosis and in transition into the interstitial cortical tissue in the different species studied. Meiosis is resumed in preantral and antral follicles, and cleavage occurs down to the morula stage. Leukocyte recruitment and capillary sprouting into the previous antrum of large antral follicles mimic a heavy inflammation as that seen in the preovulatory follicle. In analogy, granulosa cell subtypes with cytokeratin expression arise in the regressing follicle as in the preovulatory follicle. Follicular atresia, like ovulation, might depend on different degrees of oxidative stress and of danger signaling by innate immunity.

Keywords

Granulosa Cell Antral Follicle Preantral Follicle Preovulatory Follicle Follicular Atresia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Katharina Spanel-Borowski
    • 1
  1. 1.Institute of Anatomy University of LeipzigLeipzigGermany

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