Follicular Atresia as a Proliferative and Inflammatory Event

  • Katharina Spanel-Borowski


Follicular atresia is more than a process of involution. It is also a proliferative event showing granulosa cells in mitosis and in transition into the interstitial cortical tissue in the different species studied. Meiosis is resumed in preantral and antral follicles, and cleavage occurs down to the morula stage. Leukocyte recruitment and capillary sprouting into the previous antrum of large antral follicles mimic a heavy inflammation as that seen in the preovulatory follicle. In analogy, granulosa cell subtypes with cytokeratin expression arise in the regressing follicle as in the preovulatory follicle. Follicular atresia, like ovulation, might depend on different degrees of oxidative stress and of danger signaling by innate immunity.


Granulosa Cell Antral Follicle Preantral Follicle Preovulatory Follicle Follicular Atresia 
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  1. Hussein MR (2005) Apoptosis in the ovary: molecular mechanisms. Hum Reprod Update 11:162–177PubMedCrossRefGoogle Scholar
  2. Jamnongjit M, Hammes S (2005) Oocyte maturation: the coming of age of a germ cell. Semin Reprod Med 23:234–241PubMedCrossRefGoogle Scholar
  3. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL (2003) Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem 278:1561–1568PubMedCrossRefGoogle Scholar
  4. Mukhopadhyay D, Datta K (2004) Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors. Semin Cancer Biol 14:123–130PubMedCrossRefGoogle Scholar
  5. Rönnstrand L (2004) Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci 61:2535–2548PubMedCrossRefGoogle Scholar
  6. Serke H, Bausenwein J, Hirrlinger J, Nowicki M, Vilser C, Jogschies P, Hmeidan FA, Blumenauer V, Spanel-Borowski K (2010) Granulosa cell subtypes vary in response to oxidized low-density lipoprotein as regards specific lipoprotein receptors and antioxidant enzyme activity. J Clin Endocrinol Metab 95:3480–3490PubMedCrossRefGoogle Scholar
  7. Serke H, Vilser C, Nowicki M, Hmeidan FA, Blumenauer V, Hummitzsch K, Lösche MT, Spanel-Borowski K (2009) Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy 5:991–1003PubMedCrossRefGoogle Scholar
  8. Spanel-Borowski K (2011a) Footmarks of innate immunity in the ovary and cytokeratin-positive cells as potential dendritic cells, vol 209, Advances in anatomy, embryology, and cell biology. Springer, Heidelberg. ISBN 978-3-642-16076-9CrossRefGoogle Scholar
  9. Spanel-Borowski K (2011b) Ovulation as danger signaling event of innate immunity. Mol Cell Endocrinol 333:1–7PubMedCrossRefGoogle Scholar
  10. Spanel-Borowski K, Ricken AM (1997) Varying morphology of bovine granulosa cell cultures. In: Motta M (ed) Microscopy of reproduction and development: a dynamic approach. Antonio Delfino, Rome, pp 91–100Google Scholar
  11. Spanel-Borowski K, Trepel F, Schick P, Pilgrim C (1981) Aspects of cellular proliferation during follicular atresia in the dog ovary. Cell Tissue Res 219:173–183PubMedCrossRefGoogle Scholar
  12. Spanel-Borowski K, Rahner P, Ricken AM (1997) Immunolocalization of CD18-positive cells in the bovine ovary. J Reprod Fertil 111:197–205PubMedCrossRefGoogle Scholar
  13. Stewart CR, Stuart LM, Wilkinson K, van Gils J, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, Khoury J, Golenbock DT, Moore KJ (2010) CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer. Nat Immunol 11:155–161PubMedCrossRefGoogle Scholar
  14. Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R (2008) Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update 14:131–142PubMedCrossRefGoogle Scholar
  15. Tavassoli FA, Devilee P (2003) Pathology and genetics of tumours of the breast and female genital organs. International Agency for Research on Cancer, Lyon. Chapter 2, pp 113–202, ISBN 92 832 241 24Google Scholar

Copyright information

© Springer Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Katharina Spanel-Borowski
    • 1
  1. 1.Institute of Anatomy University of LeipzigLeipzigGermany

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