Skip to main content
SpringerLink
Log in

Biogenesis of Outer Membrane Vesicles

  • Chapter
  • First Online:
Book cover Outer Membrane Vesicles of Bacteria

Part of the book series: SpringerBriefs in Microbiology ((BRIEFSMICROBIOL))

  • 1217 Accesses

Abstract

The different steps involved in the formation and release of outer membrane vesicles (OMVs) from the parent bacteria as revealed by the experimental evidence and derived models presented by different investigators are discussed. An attempt has been made to develop a unified concept of the biogenesis of OMVs released by different Gram-negative bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bernadac A, Bolla JM, Lazdunski C, Inouye M, Pages JM (1987) Precise localization of an overproduced periplasmic protein in Escherichia coli: use of double immuno-gold labelling. Biol Cell 61:141–147

    Article  PubMed  CAS  Google Scholar 

  • Bernadac A, Gavioli M, Lazzaroni JC, Raina S, Lloubes R (1998) Escherichia coli tol-pal mutants form outer membrane vesicles. J Bacteriol 180:4872–4878

    PubMed  CAS  Google Scholar 

  • Bishop DG, Work E (1965) An extracellular glycolipid produced by Escherichia coli grown under lysine-limiting conditions. Biochem J 96:567–576

    PubMed  CAS  Google Scholar 

  • Brandtzaeg P, Bryn K, Kierulf P, Ovstebo R, Namork E, Aase B, Jantzen E (1992) Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy. J Clin Invest 89:816–823

    Article  PubMed  CAS  Google Scholar 

  • Cascales E, Bernadac A, Gavioli M, Lazzaroni JC, Lloubes R (2002) Pal lipoprotein of Escherichia coli plays a major role in outer membrane integrity. J Bacteriol 184:754–759

    Article  PubMed  CAS  Google Scholar 

  • Chatterjee SN, Das J (1967) Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae. J Gen Microbiol 49:1–11

    Article  PubMed  CAS  Google Scholar 

  • Corbin RW, Paliy O, Yang F, Shabanowitz J, Platt M et al (2003) Toward a protein profile of Escherichia coli: comparison to its transcription profile. Proc Natl Acad Sci USA 100:9232–9237

    Article  PubMed  CAS  Google Scholar 

  • Deatherage BL, Lara JC, Bergsbaken T, Rassoulian Barrett SL, Lara S, Cookson BT (2009) Biogenesis of bacterial membrane vesicles. Mol Microbiol 72:1395–1407

    Article  PubMed  CAS  Google Scholar 

  • Devoe IW, Gilchrist JE (1973) Release of endotoxin in the form of cell wall blebs during in vitro growth of Neisseria meningitidis. J Exp Med 138:1156–1167

    Article  PubMed  CAS  Google Scholar 

  • Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D (2001) Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin. Science 294:361–364

    Article  PubMed  CAS  Google Scholar 

  • Galka F, Wai SN, Kusch H, Engelmann S, Hecker M et al (2008) Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles. Infect Immun 76:1825–1836

    Article  PubMed  CAS  Google Scholar 

  • Henry T, Pommier S, Journet L, Bernadac A, Gorvel JP, Lloubes R (2004) Improved methods for producing outer membrane vesicles in gram-negative bacteria. Res Microbiol 155:437–446

    Article  PubMed  CAS  Google Scholar 

  • Hoekstra D, van der Laan JW, de Leij L, Witholt B (1976) Release of outer membrane fragments from normally growing Escherichia coli. Biochim Biophys Acta 455:889–899

    Article  PubMed  CAS  Google Scholar 

  • Horstman AL, Kuehn MJ (2000) Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles. J Biol Chem 275:12489–12496

    Article  PubMed  CAS  Google Scholar 

  • Hozbor D, Rodriguez ME, Fernandez J, Lagares A, Guiso N, Yantorno O (1999) Release of outer membrane vesicles from Bordetella pertussis. Curr Microbiol 38:273–278

    Article  PubMed  CAS  Google Scholar 

  • Hynes SO, Keenan JI, Ferris JA, Annuk H, Moran AP (2005) Lewis epitopes on outer membrane vesicles of relevance to Helicobacter pylori pathogenesis. Helicobacter 10:146–156

    Article  PubMed  CAS  Google Scholar 

  • Iwami J, Murakami Y, Nagano K, Nakamura H, Yoshimura F (2007) Further evidence that major outer membrane proteins homologous to OmpA in Porphyromonas gingivalis stabilize bacterial cells. Oral Microbiol Immunol 22:356–360

    Article  PubMed  CAS  Google Scholar 

  • Kadurugamuwa JL, Beveridge TJ (1995) Virulence factors are released from Pseudomonas aeruginosa in association with membrane vesicles during normal growth and exposure to gentamicin: a novel mechanism of enzyme secretion. J Bacteriol 177:3998–4008

    PubMed  CAS  Google Scholar 

  • Kato S, Kowashi Y, Demuth DR (2002) Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. Microb Pathog 32:1–13

    Article  PubMed  CAS  Google Scholar 

  • Knox KW, Vesk M, Work E (1966) Relation between excreted lipopolysaccharide complexes and surface structures of a lysine-limited culture of Escherichia coli. J Bacteriol 92:1206–1217

    PubMed  CAS  Google Scholar 

  • Kulp A, Kuehn MJ (2010) Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol 64:163–184

    Article  PubMed  CAS  Google Scholar 

  • Lazzaroni JC, Germon P, Ray MC, Vianney A (1999) The Tol proteins of Escherichia coli and their involvement in the uptake of biomolecules and outer membrane stability. FEMS Microbiol Lett 177:191–197

    Article  PubMed  CAS  Google Scholar 

  • Lee EY, Bang JY, Park GW, Choi DS, Kang JS et al (2007) Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli. Proteomics 7:3143–3153

    Article  PubMed  CAS  Google Scholar 

  • Lee EY, Choi DS, Kim KP, Gho YS (2008) Proteomics in gram-negative bacterial outer membrane vesicles. Mass Spectrom Rev 27:535–555

    Article  PubMed  CAS  Google Scholar 

  • Llamas MA, Ramos JL, Rodriguez-Herva JJ (2000) Mutations in each of the tol genes of Pseudomonas putida reveal that they are critical for maintenance of outer membrane stability. J Bacteriol 182:4764–4772

    Article  PubMed  CAS  Google Scholar 

  • Loeb MR (1974) Bacteriophage T4-mediated release of envelope components from Escherichia coli. J Virol 13:631–641

    PubMed  CAS  Google Scholar 

  • Loeb MR, Kilner J (1978) Release of a special fraction of the outer membrane from both growing and phage T4-infected Escherichia coli B. Biochim Biophys Acta 514:117–127

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch J, Templin MF, Kraft AR, Vollmer W, Holtje JV (1997) Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli. J Bacteriol 179:5465–5470

    PubMed  CAS  Google Scholar 

  • Mashburn-Warren L (2008) Quinolone trafficking via outer membrane vesicles in Pseudomonas aeruginosa. Dissertation for the Doctor of Philosophy Thesis, University of Texas, Austin

    Google Scholar 

  • McBroom AJ, Kuehn MJ (2005) Outer membrane vesicles In: III RC (ed) EcoSal—Escherichia coli and Salmonella : Cellular and Molecular Biology, American Society for Microbiology Press, Washington

    Google Scholar 

  • McBroom AJ, Kuehn MJ (2007) Release of outer membrane vesicles by gram-negative bacteria is a novel envelope stress response. Mol Microbiol 63:545–558

    Article  PubMed  CAS  Google Scholar 

  • McBroom AJ, Johnson AP, Vemulapalli S, Kuehn MJ (2006) Outer membrane vesicle production by Escherichia coli is independent of membrane instability. J Bacteriol 188:5385–5392

    Article  PubMed  CAS  Google Scholar 

  • Misra RV, Horler RS, Reindl W, Goryanin II, Thomas GH (2005) EchoBASE: an integrated post-genomic database for Escherichia coli. Nucleic Acids Res 33:D329–D333

    Article  PubMed  CAS  Google Scholar 

  • Mug-Opstelten D, Witholt B (1978) Preferential release of new outer membrane fragments by exponentially growing Escherichia coli. Biochim Biophys Acta 508:287–295

    Article  PubMed  CAS  Google Scholar 

  • Nguyen TT, Saxena A, Beveridge TJ (2003) Effect of surface lipopolysaccharide on the nature of membrane vesicles liberated from the gram-negative bacterium Pseudomonas aeruginosa. J Electron Microsc (Tokyo) 52:465–469

    Article  CAS  Google Scholar 

  • Post DM, Zhang D, Eastvold JS, Teghanemt A, Gibson BW, Weiss JP (2005) Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B. J Biol Chem 280:38383–38394

    Article  PubMed  CAS  Google Scholar 

  • Rolhion N, Barnich N, Claret L, Darfeuille-Michaud A (2005) Strong decrease in invasive ability and outer membrane vesicle release in Crohn’s disease-associated adherent-invasive Escherichia coli strain LF82 with the yfgL gene deleted. J Bacteriol 187:2286–2296

    Article  PubMed  CAS  Google Scholar 

  • Rothfield L, Pearlman-Kothencz M (1969) Synthesis and assembly of bacterial membrane components. A lipopolysaccharide-phospholipid-protein complex excreted by living bacteria. J Mol Biol 44:477–492

    Article  PubMed  CAS  Google Scholar 

  • Sabra W, Lunsdorf H, Zeng AP (2003) Alterations in the formation of lipopolysaccharide and membrane vesicles on the surface of Pseudomonas aeruginosa PAO1 under oxygen stress conditions. Microbiology 149:2789–2795

    Article  PubMed  CAS  Google Scholar 

  • Schooling SR, Beveridge TJ (2006) Membrane vesicles: an overlooked component of the matrices of biofilms. J Bacteriol 188:5945–5957

    Article  PubMed  CAS  Google Scholar 

  • Shoberg RJ, Thomas DD (1995) Borrelia burgdorferi vesicle production occurs via a mechanism independent of immunoglobulin M involvement. Infect Immun 63:4857–4861

    PubMed  CAS  Google Scholar 

  • Smalley JW, Birss AJ, McKee AS, Marsh PD (1991) Haemin-restriction influences haemin-binding, haemagglutination and protease activity of cells and extracellular membrane vesicles of Porphyromonas gingivalis W50. FEMS Microbiol Lett 69:63–67

    Article  PubMed  CAS  Google Scholar 

  • Song T, Mika F, Lindmark B, Liu Z, Schild S et al (2008) A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles. Mol Microbiol 70:100–111

    Article  PubMed  CAS  Google Scholar 

  • Sonntag I, Schwarz H, Hirota Y, Henning U (1978) Cell envelope and shape of Escherichia coli: multiple mutants missing the outer membrane lipoprotein and other major outer membrane proteins. J Bacteriol 136:280–285

    PubMed  CAS  Google Scholar 

  • Stephens DS, Edwards KM, Morris F, McGee ZA (1982) Pili and outer membrane appendages on Neisseria meningitidis in the cerebrospinal fluid of an infant. J Infect Dis 146:568

    Article  PubMed  CAS  Google Scholar 

  • Suzuki H, Nishimura Y, Yasuda S, Nishimura A, Yamada M, Hirota Y (1978) Murein-lipoprotein of Escherichia coli: a protein involved in the stabilization of bacterial cell envelope. Mol Gen Genet 167:1–9

    PubMed  CAS  Google Scholar 

  • Tan TT, Morgelin M, Forsgren A, Riesbeck K (2007) Hemophilus influenzae survival during complement-mediated attacks is promoted by Moraxella catarrhalis outer membrane vesicles. J Infect Dis 195:1661–1670

    Article  PubMed  CAS  Google Scholar 

  • Tetz VV, Rybalchenko OV, Savkova GA (1990) Ultrastructural features of microbial colony organization. J Basic Microbiol 30:597–607

    Article  PubMed  CAS  Google Scholar 

  • Wai SN, Takade A, Amako K (1995) The release of outer membrane vesicles from the strains of enterotoxigenic Escherichia coli. Microbiol Immunol 39:451–456

    PubMed  CAS  Google Scholar 

  • Wensink J, Witholt B (1981) Outer-membrane vesicles released by normally growing Escherichia coli contain very little lipoprotein. Eur J Biochem 116:331–335

    Article  PubMed  CAS  Google Scholar 

  • Work E, Knox KW, Vesk M (1966) The chemistry and electron microscopy of an extracellular lipopolysaccharide from Escherichia coli. Ann NY Acad Sci 133:438–449

    Article  PubMed  CAS  Google Scholar 

  • Yem DW, Wu HC (1978) Physiological characterization of an Escherichia coli mutant altered in the structure of murein lipoprotein. J Bacteriol 133:1419–1426

    PubMed  CAS  Google Scholar 

  • Yonezawa H, Osaki T, Kurata S, Fukuda M, Kawakami H et al (2009) Outer membrane vesicles of Helicobacter pylori TK1402 are involved in biofilm formation. BMC Microbiol 9:197

    Article  PubMed  Google Scholar 

  • Zhou L, Srisatjaluk R, Justus DE, Doyle RJ (1998) On the origin of membrane vesicles in gram-negative bacteria. FEMS Microbiol Lett 163:223–228

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biophysics, Formerly of Saha Institute of Nuclear Physics, Bidhan Nagar, Sector 1 Block-CF-69, Kolkata, 700064, India

    S. N. Chatterjee

  2. Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S.C. Mullick Rd. 4, Kolkata, 700032, India

    Keya Chaudhuri

Authors
  1. S. N. Chatterjee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keya Chaudhuri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. N. Chatterjee .

Rights and permissions

Reprints and permissions

Copyright information

© 2012 The Author(s)

About this chapter

Cite this chapter

Chatterjee, S.N., Chaudhuri, K. (2012). Biogenesis of Outer Membrane Vesicles. In: Outer Membrane Vesicles of Bacteria. SpringerBriefs in Microbiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30526-9_7

Download citation

Publish with us

Policies and ethics

Search

Navigation