• Thomas  E. Ouldridge
Part of the Springer Theses book series (Springer Theses)


This thesis introduces a novel coarse-grained model of DNA which is specifically designed to capture the structural, mechanical and thermodynamic properties associated with single-stranded and duplex DNA, and the transition between the two. The model has been shown to give a physically reasonable description of a range of DNA properties, and has been applied to two nanotechnological systems (DNA tweezers and a two-footed DNA walker). These studies represent the first investigations into dynamic DNA devices using a coarse-grained model.


Single Strand Sequence Dependence Displacement Process Strand Displacement Duplex Formation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Thomas  E. Ouldridge
    • 1
  1. 1.University of OxfordOxfordUK

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