Thermodynamic Properties of Model DNA

  • Thomas  E. Ouldridge
Part of the Springer Theses book series (Springer Theses)


The attractive stacking interaction between adjacent bases causes single strands to form helical stacks at low temperature, with this order being disrupted as the temperature increases. The literature is divided on both the nature of the attraction and the thermodynamics of the transition. The relative contributions of van der Waals, induced dipole, hydrophobic and permanent polar/electrostatic interactions remain unclear.


Partition Function Statistical Weight Duplex Formation Umbrella Sampling Free Energy Profile 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Thomas  E. Ouldridge
    • 1
  1. 1.University of OxfordOxfordUK

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