Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo

  • Aurélien Courtois
  • Takashi Hiiragi
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 55)


The transition from meiosis to mitosis is a fundamental process to guarantee the successful development of the embryo. In the mouse, the transition includes extensive reorganisation of the division machinery, centrosome establishment and changes in spindle proprieties and characteristic. Recent findings indicate that this transition is gradual and lasts until the late blastocyst stage. In-depth knowledge of the mechanisms underlying the transition would provide new insight into de novo centrosome formation and regulation of spindle size and proprieties. Here, we review recent advances in the understanding of acentrosomal spindle formation, centriole establishment and the meiosis-to-mitosis transition in the mouse pre-implantation embryo.


Spindle Pole Early Mouse Embryo Mouse Zygote Microtubule Aster Centriole Duplication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Developmental Biology UnitEuropean Molecular Biology LaboratoryHeidelbergGermany
  2. 2.Institute for Integrated Cell-Material Sciences (WPI-iCeMS)Kyoto UniversityKyotoJapan

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