Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo
The transition from meiosis to mitosis is a fundamental process to guarantee the successful development of the embryo. In the mouse, the transition includes extensive reorganisation of the division machinery, centrosome establishment and changes in spindle proprieties and characteristic. Recent findings indicate that this transition is gradual and lasts until the late blastocyst stage. In-depth knowledge of the mechanisms underlying the transition would provide new insight into de novo centrosome formation and regulation of spindle size and proprieties. Here, we review recent advances in the understanding of acentrosomal spindle formation, centriole establishment and the meiosis-to-mitosis transition in the mouse pre-implantation embryo.
KeywordsSpindle Pole Early Mouse Embryo Mouse Zygote Microtubule Aster Centriole Duplication
- Courtois A, Schuh M, Ellenberg J, Hiiragi T. (2012) The transition from meiotic to mitotic spindle assembly proceeds gradually during early mammalian development. J Cell Biol 198(3): 357–370Google Scholar
- Kubiak JZ, Prigent C (2012) The centrosome life story in Xenopus leavis. In: Schatten H (Ed.) The centrosome: cell and molecular mechanisms of functions and dysfunctions in disease. Humana Press (in press)Google Scholar