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Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy

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Mouse Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 55))

Abstract

Oocyte maturation and early embryo development require precise coordination between cell cycle progression and the developmental programme. Cyclin B plays a major role in this process: its accumulation and degradation is critical for driving the cell cycle through activation and inactivation of the major cell cycle kinase, CDK1. CDK1 activation is required for M-phase entry whereas its inactivation leads to exit from M-phase. The tempo of oocyte meiotic and embryonic mitotic divisions is set by the rate of cyclin B accumulation and the timing of its destruction. By controlling when cyclin B destruction is triggered and by co-ordinating this with the completion of chromosome alignment, the spindle assembly checkpoint (SAC) is a critical quality control system important for averting aneuploidy and for building in the flexibility required to better integrate cell cycle progression with development. In this review we focus on cyclin B metabolism in mouse oocytes and embryos and illustrate how the cell cycle-powered clock (in fact cyclin B-powered clock) controls oocyte maturation and early embryo development, thereby providing important insight into human reproduction and potential causes of Down syndrome.

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Acknowledgements

While writing this article, JZK was supported by a grant from ARC. HH is supported by a Wellcome Trust Fellowship. ZP was supported by the Polish National Science Centre (grant N° DEC-2011/B/NZ3/00190).

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Authors and Affiliations

  1. Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, 30-387, Kraków, Poland

    Zbigniew Polański

  2. Mammalian Oocyte and Embryo Research Laboratory, Institute for Women’s Health, University College London and University College London Hospitals NHS Foundation Trust, London, WC1E 6BT, UK

    Hayden Homer

  3. Department of Obstetrics and Gynaecology, Institute for Women’s Health, University College London and University College London Hospitals NHS Foundation Trust, London, WC1E 6BT, UK

    Hayden Homer

  4. Institut de Génétique et Développement de Rennes, CNRS, UMR 6290, Rennes, F-35043, France

    Jacek Z. Kubiak

  5. IFR 140, Faculté de Médecine, Université Rennes 1, UEB, Rennes, F-35043, France

    Jacek Z. Kubiak

Authors
  1. Zbigniew Polański
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  2. Hayden Homer
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  3. Jacek Z. Kubiak
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Correspondence to Jacek Z. Kubiak .

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Editors and Affiliations

  1. CNRS UMR 6061, Fac. Médecine, Université de Rennes 1, Rennes CX, 35043, France

    Jacek Z. Kubiak

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Polański, Z., Homer, H., Kubiak, J.Z. (2012). Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy. In: Kubiak, J. (eds) Mouse Development. Results and Problems in Cell Differentiation, vol 55. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30406-4_4

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