Mining Local Connectivity Patterns in fMRI Data
A core task in the analysis of functional magnetic resonance imaging (fMRI) data is to detect groups of voxels that exhibit synchronous activity while the subject is performing a certain task. Synchronous activity is typically interpreted as functional connectivity between brain regions. We compare classical approaches like statistical parametric mapping (SPM) and some new approaches that are loosely based on frequent pattern mining principles, but restricted to the local neighborhood of a voxel. In particular, we examine how a soft notion of activity (rather than a binary one) can be modeled and exploited in the analysis process. In addition, we explore a fault-tolerant notion of synchronous activity of groups of voxels in both the binary and the soft/fuzzy activity setting. We apply the methods to fMRI data from a visual stimulus experiment to demonstrate their usefulness.
KeywordsFunctional Connectivity Blood Oxygen Level Dependent fMRI Data Statistical Parametric Mapping Local Connectivity
Unable to display preview. Download preview PDF.
- 2.Cordes, D., Haughton, V.M., Arfanakis, K., Carew, J.D., Turski, P.A., Moritz, C.H., Quigley, M.A., Meyerand, M.E.: Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in “Resting-state” Data. American Journal of Neuroradiology 22(7), 1326–1333 (2001)Google Scholar
- 6.Hollmann, M., Mönch, T., Mulla-Osman, S., Tempelmann, C., Stadler, J., Bernarding, J.: A New Concept of a Unified Parameter Management, Experiment Control, and Data Analysis in fMRI: Application to Real-time fMRI at 3T and 7T. Journal of Neuroscience Methods 175(1), 154–162 (2008)CrossRefGoogle Scholar
- 12.Tschukalin, A.: Noninvasive Lokalisation von magno- und parvozellulären Anteilen des humanen CGL mittels Hochfeld-MRT. Bachelor Thesis. Dept. of Computer Science, Otto-von-Guericke Universität Magdeburg, Germany (2011)Google Scholar