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Ovarielles Überstimulationssyndrom

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Zusammenfassung

Komplikationen in der Sterilitätstherapie sind zwar gemeinhin eher selten, können aber, wie auch im Falle des ovariellen Überstimulationssyndroms (OHSS), im Einzelfall ein ernstes und potenziell lebensbedrohliches Ausmaß annehmen (Zivi et al. 2010; Budev et al. 2005).

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Literatur

  • Abdallah R, Kligman I, Davis O, Rosenwaks Z (2010) Withholding gonadotropins until human chorionic gonadotropin administration. Semin Reprod Med 28 (6): 486–492

    Article  PubMed  CAS  Google Scholar 

  • Al-Ramahi M, Leader A, Claman P, Spence J (1997) A novel approach to the treatment of ascites associated with ovarian hyperstimulation syndrome. Hum Reprod 12 (12): 2614–2616

    Article  PubMed  CAS  Google Scholar 

  • Alvarez C, Alonso-Muriel I, García G, Crespo J, Bellver J, Simón C, Pellicer A (2007) Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study. Hum Reprod 22 (12): 3210–3214

    Article  PubMed  CAS  Google Scholar 

  • Alvarez C, Marti-Bonmati L, Novella-Maestre E, Sanz R, Gómez R, Fernández-Sánchez M, Simón C, Pellicer A (2007) Dopamine agonistcabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction. J Clin Endocrinol Metab 92 (8): 2931–2937

    Article  PubMed  CAS  Google Scholar 

  • Artini PG, Monti M, Fasciani A, Battaglia C, D’Ambrogio G, Genazzani AR (2002) Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol 101 (2): 169–174

    Article  PubMed  CAS  Google Scholar 

  • Bar-Hava I, Orvieto R, Dicker D, Dekel A, Peley D, Ben-Rafael Z (1995) A severe case of ovarian hyperstimulation syndrome: 65 liters of ascites aspirated in an on-going IVF-ET twin pregnancy. Gynecol Endocrinol 9 (4): 295–298

    Article  PubMed  CAS  Google Scholar 

  • Binder H, Flegel W, Emran J, Müller A, Cupisti S, Beckmann MW, Eckstein R, Dittrich R, Ringwald J (2008) Blood group A: an overseen risk factor for early-onset ovarian hyperstimulation syndrome? Reprod Biomed Online 17 (2): 185–189

    Article  PubMed  Google Scholar 

  • Binder H, Griesinger G, Kiesel L (2007) Ovarielles Überstimulationssyndrom. Gynäkol Endokrinol 5 (4): 203–211

    Article  CAS  Google Scholar 

  • Bonilla-Musoles FM, Raga F, Castillo JC, Sanz M, Dolz M, Osborne N (2009) High doses of GnRH antagonists are efficient in the management of severe ovarian hyperstimulation syndrome. Clin Exp Obstet Gynecol 36 (2): 78–81

    PubMed  CAS  Google Scholar 

  • Brinsden PR, Wada I, Tan SL, Balen S, Jacobs HS (1995) Diagnosis, prevention and management of ovarian hyperstimulation syndrome. BJOG 102 (10): 767–772

    Article  CAS  Google Scholar 

  • Budev MM, Arroliga AC, Falcone T (2005) Ovarian hyperstimulation syndrome. Crit Care Med 33 (10): 301–306

    Article  Google Scholar 

  • Cerrillo M, Rodriguez S, Mayoral M, Pacheco A, Martínez-Salazar J, Garcia-Velasco JA (2009) Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction. Fertil Steril 91 (4): 1526–1528

    Article  PubMed  CAS  Google Scholar 

  • Chen SU, Chou CH, Lin CW, Lee H, Wu JC, Lu HF, Chen CD, Yang YS (2010) Signal mechanisms of vascular endthelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways. Hum Reprod 25 (3): 757–767

    Article  PubMed  CAS  Google Scholar 

  • Delbaere A, Bergmann PJ, Gervy-Decoster C, Staroukine M, Englert Y (1994) Angiotensin II immunoreactivity is elevated in ascites during severe ovarian hyperstimulation syndrome: implications for pathophysiology and clinical management. Fertil Steril 62 (4): 731–437

    PubMed  CAS  Google Scholar 

  • Delbaere A, Smits G, Olatunbosun O, Pierson R, Vassart G, Costagliola S (2004) New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome? Hum Reprod 19 (3): 486–489

    Article  PubMed  CAS  Google Scholar 

  • Delbaere A, Smits G, Vassart G, Costagliola S (2006) Genetic predictors of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. Nat Clin Pract Endocrinol Metab 2 (11): 590–591

    Article  PubMed  Google Scholar 

  • Deutsches IVF-Register – DIR (2010) DIR Jahrbuch 2009. J Reproduktionsmed Endokrinol 2010: 470–497 [http://www.deutsches-ivfregister.de]

  • Elchalal U, Schenker JG (1997) The pathophysiology of ovarian hyperstimulation syndrome – views and ideas. Hum Reprod 12 (6): 1129–37

    Article  PubMed  CAS  Google Scholar 

  • Forman RG, Frydman R, Egan D, Ross C, Barlow DH (1990) Severe ovarian hyperstimulation syndrome using agonists of gonadotropinreleasing hormone for in vitro fertilization: a European series and a proposal for prevention. Fertil Steril 53 (3): 502–509

    PubMed  CAS  Google Scholar 

  • Gao MZ, Zhao XM, Sun ZG, Hong Y, Zhao LW, Zhang HQ (2011) Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation. Fertil Steril 95 (2): 673–678

    Article  PubMed  CAS  Google Scholar 

  • Golan A, Ron-el R, Herman A, Soffer Y, Weinraub Z, Caspi E (1989) Ovarian hyperstimulation syndrome: an update review. Obstet Gynecol Surv 44 (6): 430–440

    Article  PubMed  CAS  Google Scholar 

  • Griesinger G, Diedrich K, Tarlatzis BC, Kolibianakis EM (2006) GnRHantagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis. Reprod Biomed Online 13 (5): 628–638

    Article  PubMed  CAS  Google Scholar 

  • Griesinger G, Binder H, Diedrich K (2008) Neue Ansätze bei der Prävention des ovariellen Überstimulationssyndroms. Gynäkol Endokrinol 6 (3): 165–170

    Article  CAS  Google Scholar 

  • Kerkelä E, Skottman H, Friden B, Bjuresten K, Kere J, Hovatta O (2006) Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome. Fertil Steril 87 (3): 603–606

    Article  PubMed  Google Scholar 

  • Kissler S, Neidhardt B, Siebzehnrübl E, Schmitt H, Tschaikowsky K, Wildt L (2001) The detrimental role of colloidal volume substitutes in severe ovarian hyperstimulation syndrome: a case report. Eur J Obstet Gynecol Reprod Biol 99 (1): 131–134

    Article  PubMed  CAS  Google Scholar 

  • Kolibianakis EM, Collins J, Tarlatzis BC, Devroey P, Diedrich K, Griesinger G (2006) Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis. Hum Reprod Update 12 (6): 651–671

    Article  PubMed  CAS  Google Scholar 

  • Kolibianakis EM, Papanikolaou EG, Tournaye H, Camus M, Van Steirteghem AC, Devroey P (2007) Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. Fertil Steril 88 (5): 1382–1388

    Article  PubMed  CAS  Google Scholar 

  • Kosaka K, Fujiwara H, Yoshioka S, Fujii S (2007) Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome. Hum Reprod 22 (6): 1647–1651

    Article  PubMed  Google Scholar 

  • Mathur RS, Jenkins JM (2000) Is ovarian hyperstimulation syndrome associated with a poor obstetric outcome? BJOG 107 (8): 943–946

    Article  PubMed  CAS  Google Scholar 

  • McClure N, Leya J, Radwanska E, Rawlins R, Haning RV Jr (1992) Luteal phase support and severe ovarian hyperstimulation syndrome. Hum Reprod 7 (6): 758–764

    PubMed  CAS  Google Scholar 

  • McElhinney B, Ardill J, Caldwell C, Lloyd F, McClure N (2002) Ovarian hyperstimulation syndrome and assisted reproductive technologies: why some and not others? Hum Reprod 17 (6): 1548–53

    Article  PubMed  Google Scholar 

  • Mensah J, Kimmig R, Schmidt M (2010) Ovarielles Überstimulationssyndrom in einer aneuploiden Gravidität. Geburtsh Frauenheilk 70 (10): 828–831

    Article  Google Scholar 

  • Morris RS, Paulson RJ (1994) Ovarian derived prorenin-angiotensin cascade in human reproduction. Fertil Steril 62 (2): 1105–1114

    PubMed  CAS  Google Scholar 

  • Muller P (1962) Gonadotrophines en gynécologie. Masson, Paris

    Google Scholar 

  • Nargund G, Hutchison L, Scaramuzzi R, Campbell S (2007) Low-dose HCG is useful in preventing OHSS in high-risk women without adversely affecting the outcome of IVF cycles. Reprod Biomed Online 14 (6): 682–685

    Article  PubMed  CAS  Google Scholar 

  • Navot D, Bergh P, Laufer N (1992) Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment. Fertil Steril 58 (2): 249–261

    PubMed  CAS  Google Scholar 

  • Neulen J, Yan Z, Raczek S, Weindel K, Keck C, Weich HA, Marmé D, Breckwoldt M (1995) Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome. J Clin Endocrinol Metab 80 (6): 1967–1971

    Article  PubMed  CAS  Google Scholar 

  • Olivennes F (2010) Ovarian hyperstimulation syndrome prevention strategies: individualizing gonadotropin dose. Semin Reprod Med 28 (6): 463–467

    Article  PubMed  CAS  Google Scholar 

  • Papanikolaou EG, Tournaye H, Verpoest W, Camus M, Vernaeve V, Van Steirteghem A, Devroey P (2005) Early and late ovarian hyperstimulation syndrome: early pregnancy outcome and profile. Hum Reprod 20 (3): 636–641

    Article  PubMed  Google Scholar 

  • Papanikolaou EG, Humaidan P, Polyzos NP, Tarlatzis B (2010) Identification of the high-risk patient for ovarian hyperstimulation syndrome. Semin Reprod Med 28 (6): 458–462

    Article  PubMed  CAS  Google Scholar 

  • Pellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohí J, Simón C (1999) The pathogenesis of ovarian hyperstimulation syndrome: in vivo studies investigating the role of interleukin-1beta, interleukin- 6, and vascular endothelial growth factor. Fertil Steril. 71 (3): 482–489

    Article  PubMed  CAS  Google Scholar 

  • Raziel A, Friedler S, Schachter M, Strassburger D, Mordechai E, Ron-El R (2002) Increased eraly pregnancy loss in IVF patients with severe ovarian hyperstimulation syndrome. Hum Reprod 17 (1): 107–110

    Article  PubMed  Google Scholar 

  • Rizk B (2009) Symposium: Update on prediction and management of OHSS. Genetics of ovarian hyperstimulation syndrome. Reprod Biomed Online 19 (1): 14–27

    Article  PubMed  CAS  Google Scholar 

  • Rizk B, Aboulghar M (1995) Classification, pathophysiology and management of ovarian hyperstimulation syndrome. London: In vitro Fertilization and AssistedReproduction

    Google Scholar 

  • Rollene NL, Amols MH, Hudson SB, Coddington CC (2009) Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: a case series. Fertil Steril 92 (3): 1169.e15–7

    Article  Google Scholar 

  • Shapiro AG, Thomas T, Epstein M (1977) Management of hyperstimulation syndrome. Fertil Steril 28 (3): 237–239

    PubMed  CAS  Google Scholar 

  • Tan SL, Child TJ, Cheung AP, Fluker MR, Yuzpe A, Casper R, Leung P, Cadesky K, Davis VJ (2005) A randomized, double-blind, multicenter study comparing a starting dose of 100 IU or 200 IU of recombinant follicle stimulating hormone (Puregon) in women undergoing controlled ovarian hyperstimulation for IVF treatment. J Assist Reprod Genet 22 (2): 81–88

    Article  PubMed  Google Scholar 

  • The European Recombinant LH Study Group (2001) Human recombinant luteinizing hormone is as effective as, but safer than, urinary chorionic gonadotropin in inducing follicular maturation and ovulation in in vitro fertilization procedures: results of a multicenter double-blind study. JCEM 86: 2607–2618

    Google Scholar 

  • Wang TH, Horng SG, Chang CL, Wu HM, Tsai YJ, Wang HS, Soong YK (2002) Human chorionic gonadotropin-induced ovarian hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor. J Clin Endocrinol Metab 87 (7): 3300–3308

    Article  PubMed  CAS  Google Scholar 

  • Zalel Y, Katz Z, Caspi B, Ben-Hur H, Dgani R, Insler V (1992) Spontaneous ovarian hyperstimulation syndrome concomitant with spontaneous pregnancy in a woman with polycystic ovary disease. Am J Obstet Gynecol 167 (1): 122–124

    Article  PubMed  CAS  Google Scholar 

  • Zivi E, Simon A, Laufer N (2010) Ovarian hyperstimulation syndrome: definition, incidence, and classification. Semin Reprod Med 28 (6): 441–447

    Article  PubMed  CAS  Google Scholar 

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Hess, A., Krüssel, J., Baston-Büst, D. (2013). Ovarielles Überstimulationssyndrom. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30181-0_28

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  • DOI: https://doi.org/10.1007/978-3-642-30181-0_28

  • Publisher Name: Springer, Berlin, Heidelberg

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