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Chronisch-entzündliche Darmerkrankungen

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Kinderchirurgie

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Zusammenfassung

Chronisch-entzündliche Darmerkrankungen (Morbus Crohn und Colitis ulcerosa) werden bei 25–30% der Patienten bereits im Kindes- und Jugendalter manifest. Die Entzündung verläuft in chronisch-rezidivierenden Schüben, eine Ursache ist bis heute nicht bekannt. Bereits 1932 von Burrill B. Crohn als „Ileitis terminalis“ erstmals beschrieben, wurde rasch erkennbar, dass auch der Morbus Crohn nicht nur auf das terminale Ileum beschränkt bleibt. Daher muss mit moderner Diagnostik der gesamte Gastrointestinaltrakt dargestellt werden, um eine individuelle Therapie zu planen.

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Literatur

  • Abdullah BA, Gupta SK, Croffie JM, Pfefferkorn MD, Molleston JP, Corkins MR, Fitzgerald JF (2002) The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study. J Pediatr Gastroenterol Nutr 35:636–640

    Article  PubMed  Google Scholar 

  • Alexopoulou E, Xenophontos PE, Economopoulos N, Spyridopoulos TN, Papakonstantinou O, Panayotou I, Dimakou K, Roma E, Kelekis NL (2012) Investigative Magnetic Resonance Cholangiopancreatography fpr Primary Sclerosing Cholangitis (PSC)-type lesions in children with Inflammatory Bowel Disease (IBD): Results from a cross-sectional study. J Pediatr Gastroenterol Nutr 55(3):308–13

    Article  PubMed  Google Scholar 

  • Arguelles-Arias F, Caunedo A, Romero J, Sanchez A, Rodriguez-Tellez M, Pellicer FJ, Arguelles-Martin F, Herrerias JM (2004) The value of capsule endoscopy in pediatric patients with a suspicion of Crohn’s disease. Endoscopy 36:869–873

    Article  PubMed  CAS  Google Scholar 

  • Baldassano RN, Han PD, Jeshion WC, Berlin JA, Piccoli DA, Lautenbach E, Mick R, Lichtenstein GR (2001) Pediatric Crohn’s disease: risk factors for postoperative recurrence. Am J Gastroenterol 96:2169–2176

    Article  PubMed  CAS  Google Scholar 

  • Becker JM (1999) Surgical therapy for ulcerative colitis and Crohn’s disease. Gastroenterol Clin North Am 28:371–390

    Article  PubMed  CAS  Google Scholar 

  • Bernstein CN, Wajda A, Svenson LW, MacKenzie A, Koehoorn M, Jackson M, Fedorak R, Israel D, Blanchard JF (2006) The epidemiology of inflammatory bowel disease in Canada: a population-based study. Am J Gastroenterol 101:1559–1568

    Article  PubMed  Google Scholar 

  • Borthne AS, Abdelnoor M, Rugtveit J, Perminow G, Reiseter T, Klow NE (2006) Bowel magnetic resonance imaging of pediatric patients with oral mannitol MRI compared to endoscopy and intestinal ultrasound. Eur Radiol 16:207–214

    Article  PubMed  Google Scholar 

  • Bunn SK, Bisset WM, Main MJ, Golden BE (2001) Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 32:171–177

    Article  PubMed  CAS  Google Scholar 

  • Canani RB, de Horatio LT, Terrin G, Romano MT, Miele E, Staiano A, Rapacciuolo L, Polito G, Bisesti V, Manguso F, Vallone G, Sodano A, Troncone R (2006) Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr 42:9–15

    Article  PubMed  Google Scholar 

  • Casson DH, Eltumi M, Tomlin S, Walker-Smith JA, Murch SH (2000) Topical tacrolimus may be effective in the treatment of oral and perineal Crohn’s disease. Gut 47:436–440

    Article  PubMed  CAS  Google Scholar 

  • Colombel JF, Loftus EV Jr, Tremaine WJ, Egan LJ, Harmsen WS, Schleck CD, Zinsmeister AR, Sandborn WJ (2004) The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic experience in 500 patients. Gastroenterology 126:19–31

    Article  PubMed  CAS  Google Scholar 

  • Connell WR, Kamm MA, Dickson M, Balkwill AM, Ritchie JK, Lennard-Jones JE (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343:1249–1252

    Article  PubMed  CAS  Google Scholar 

  • Bousvaros A, Kirschner BS, Werlin SL, Parker-Hartigan L, Daum F, Freeman KB, Balint JP, Day AS, Griffiths AM, Zurakowski D, Ferry GD, Leichtner AM (2000) Oral tacrolimus treatment of severe colitis in children. J. Pediatr 137:794–799

    Article  CAS  Google Scholar 

  • Boyle B, Mackner L, Ross C, Moses J, Kumar S, Crandall W (2010) A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn disease. J Pediatr Gastroenterol Nutr 51:714–717

    Article  PubMed  CAS  Google Scholar 

  • Bunn SK, Bisset WM, Main MJ, Golden BE (2001) Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 32:171–177

    Article  PubMed  CAS  Google Scholar 

  • Borrelli O, Cordischi L, Cirulli M, Paganelli M, Labalestra V, Uccini S, Russo PM, Cucchiara S (2006) Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clin Gastroenterol Hepatol 4:744–753

    Article  PubMed  Google Scholar 

  • Cameron FL, Gerasimidis K, Papangelou A, Missiou D, Garrick V, Cardigan T, Buchanan E, Barclay AR, McGrogan P, Russell RK (2013) Clinical progress in the two years following a course of exclusive enteral nutrition in 109 paediatric patients with Crohn’s disease. Aliment Pharmacol Ther 37:622–629

    Article  PubMed  CAS  Google Scholar 

  • de Ridder L, Weersma RK, Dijkstra G van der, Benninga MA, Nolte IM, Taminiau JA, Hommes DW, Stokkers PC (2007) Genetic susceptibility has a more important role in pediatric-onset Crohn’s disease than in adult-onset Crohn’s disease. Inflamm Bowel Dis 13:1083–1092

    Article  PubMed  Google Scholar 

  • Diamond IR, Langer JC (2001) Laparoscopic-assisted versus open ileocolic resection for adolescent Crohn disease. J Pediatr Gastroenterol Nutr 33:543–547

    Article  PubMed  CAS  Google Scholar 

  • Dolgin SE (2007) Surgical management of upper gastrointestinal and small bowel Crohn’s disease. Semin. Pediatr Surg 16:172–177

    Article  Google Scholar 

  • Egan LJ, Sandborn WJ, Tremaine WJ (1998) Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn’s disease with intravenous cyclosporine. Am J Gastroenterol 93:442–448

    Article  PubMed  CAS  Google Scholar 

  • Eidelwein AP, Thompson R, Fiorino K, Abadom V, Oliva-Hemker M (2007) Disease presentation and clinical course in black and white children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 44:555–560

    Article  PubMed  Google Scholar 

  • Ekbom A, Helmick C, Zack M, Adami HO (1990) Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement. Lancet 336:357–359

    Article  PubMed  CAS  Google Scholar 

  • Eliakim R, Fischer D, Suissa A, Yassin K, Katz D, Guttman N, Migdal M (2003) Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol 15:363–367

    Article  PubMed  Google Scholar 

  • Feldstein AE, Perrault J, El Youssif M, Lindor KD, Freese DK, Angulo P (2003) Primary sclerosing cholangitis in children: a long-term follow-up study. Hepatology 38:210–217)

    Article  PubMed  Google Scholar 

  • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D´Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russel R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D´Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn´s disease susceptibility loci. Nat Genet 42: 1118–1125

    Article  PubMed  CAS  Google Scholar 

  • Griffiths AM (2004) Specificities of inflammatory bowel disease in childhood. Best Pract Res Clin Gastroenterol 18:509–523

    Article  PubMed  Google Scholar 

  • Griffiths AM, Ohlsson A, Sherman PM, Sutherland LR (1995) Meta-analysis of enteral nutrition as a primary treatment of active Crohn’s disease. Gastroenterology 108:1056–1067

    Article  PubMed  CAS  Google Scholar 

  • Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P (2002) Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet 359:1541–1549

    Article  PubMed  CAS  Google Scholar 

  • Hanauer SB, Present DH T (2003) The state of the art in the management of inflammatory bowel disease. Rev Gastroenterol Disord 3:81–92

    PubMed  Google Scholar 

  • Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, Liu G, Travers S, Heuschkel R, Markowitz J, Cohen S, Winter H, Veereman-Wauters G, Ferry G, Baldassano R (2007) Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology 132:863–873

    Article  PubMed  CAS  Google Scholar 

  • Jose FA, Heyman MB (2008) Extraintestinal manifestations of inflammatory bowel disease. J Pediatr Gastroenterol Nutr 46:124–133

    Article  PubMed  Google Scholar 

  • Kirschner BS (1998) Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease. Gastroenterology 115:813–821

    Article  PubMed  CAS  Google Scholar 

  • Koivusalo A, Pakarinen MP, Rintala RJ (2007) Surgical complications in relation to functional outcomes after ileoanal anastomosis in pediatric patients with ulcerative colitis. J Pediatr Surg 42:290–295

    Article  PubMed  Google Scholar 

  • Kugathasan S, Nebel J, Skelton JA, Markowitz J, Keljo D, Rosh J, Leleiko N, Mack D, Griffiths A, Bousvaros A, Evans J, Mezoff A, Moyer S, Oliva-Hemker M, Otley A, Pfefferkorn M, Crandall W, Wyllie R, Hyams J (2007) Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts. J Pediatr 151:523–527

    Article  PubMed  Google Scholar 

  • Lehtinen P, Ashorn M, Iltanen S, Jauhola R, Jauhonen P, Kolho KL, Auvinen A (2011) Incidence trends of pediatric inflammatory bowel disease in Finland, 1987–2003, a nationwide study. Inflamm Bowel Dis 17:1778–1783

    Article  PubMed  Google Scholar 

  • Lindor KD (2011) New treatment strategies for primary sclerosing cholangitis. Dig Dis 29:113–116

    Article  PubMed  Google Scholar 

  • Loftus CG, Loftus EV, Jr, Harmsen WS, Zinsmeister AR, Tremaine WJ, Melton LJ, III, Sandborn WJ (2007) Update on the incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000. Inflamm Bowel Dis 13:254–261

    Article  PubMed  Google Scholar 

  • Loftus EV, Jr, Harewood GC, Loftus CG, Tremaine WJ, Harmsen WS, Zinsmeister AR, Jewell DA, Sandborn WJ (2005) PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 54:91–96

    Article  PubMed  Google Scholar 

  • Mack DR, Langton C, Markowitz J, Leleiko N, Griffiths A, Bousvaros, A, Evans J, Kugathasan S, Otley A, Pfefferkorn M, Rosh J, Mezoff A, Moyer S, Oliva-Hemker M, Rothbaum R, Wyllie R, delRosario JF, Keljo D, Lerer T, Hyams J (2007) Laboratory values for children with newly diagnosed inflammatory bowel disease. Pediatrics 119:1113–1119

    Article  PubMed  Google Scholar 

  • Mack DR, Young R, Kaufman SS, Ramey L, Vanderhoof JA (1998) Methotrexate in patients with Crohn’s disease after 6-mercaptopurine. J Pediatr 132:830–835

    Article  PubMed  CAS  Google Scholar 

  • Meier AH, Roth L, Cilley RE, Dillon PW (2007) Completely minimally invasive approach to restorative total proctocolectomy with j-pouch construction in children. Surg Laparosc Endosc Percutan Tech 17:418–421

    Article  PubMed  Google Scholar 

  • Neurath MF, Wanitschke R, Peters M, Krummenauer F, Meyer zum Buschenfelde KH, Schlaak JF (1999) Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn’s disease. Gut 44:625–628

    Article  PubMed  CAS  Google Scholar 

  • Ong JC, O’Loughlin EV, Kamath KR, Dorney SF, De Silva M, Gaskin KJ (1994) Sclerosing cholangitis in children with inflammatory bowel disease. Aust NZ J Med 24:149–153

    Article  CAS  Google Scholar 

  • Peppercorn MA (1997) Antibiotics are effective therapy for Crohn’s disease. Inflamm Bowel Dis 3:318–319

    PubMed  CAS  Google Scholar 

  • Proctor ML, Langer JC, Gerstle, JT, Kim PC (2002) Is laparoscopic subtotal colectomy better than open subtotal colectomy in children? J Pediatr Surg 37:706–708

    Article  PubMed  CAS  Google Scholar 

  • Punati J, Markowitz J, Lerer T, Hyams J, Kugathasan S, Griffiths A, Otley A, Rosh J, Pfefferkorn M, Mack D, Evans J, Bousvaros A, Moyer MS, Wyllie R, Oliva-Hemker M, Mezoff A, Leleiko N, Keljo D, Crandall W (2008) Effect of early immunomodulator use in moderate to severe pediatric Crohn disease. Inflamm Bowel Dis 14:949–954

    Article  PubMed  Google Scholar 

  • Reinshagen M, Schutz E, Armstrong VW, Behrens C von, Stallmach A, Herfarth H, Stein J, Bias P, Adler G, Shipkova M, Kruis W, Oellerich M von (2007) 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. Clin Chem 53:1306–1314

    Article  PubMed  CAS  Google Scholar 

  • Ridder RM, Kreth HW, Kiss E, Grone HJ, Gordjani N (2005) Membranous nephropathy associated with familial chronic ulcerative colitis in a 12-year-old girl. Pediatr Nephrol 20:1349–1351

    Article  PubMed  Google Scholar 

  • Russell RK, Wilson ML, Loganathan S, Bourke B, Kiparissi F, Mahdi G, Torrente F, Rodrigues A, Davies I, Thomas A, Akobeng AK, Fagbemi A, Hyer W, Spray C, Vaish S, Rogers P, McGrogan P, Heuschkel RB, Ayub N, Fell JM, Afzal NA, Green M, Murphy MS, Rao P, Shah N, Ho GT, Naik S, Wilson DC (2011) A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease. Aliment Pharmacol Ther 33:946–953

    Article  PubMed  CAS  Google Scholar 

  • Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns, J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF (2005) Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 353:2462–2476

    Article  PubMed  CAS  Google Scholar 

  • Sabery N, Bass D (2007) Use of serologic markers as a screening tool in inflammatory bowel disease compared with elevated erythrocyte sedimentation rate and anemia. Pediatrics 119:e193–e199

    Google Scholar 

  • Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters, PA, Travers, SB, Blank MA, van Deventer SJ (2004) Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med 350:876–885

    Article  PubMed  CAS  Google Scholar 

  • Sawczenko A, Sandhu BK (2003) Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child 88:995–1000

    Article  PubMed  CAS  Google Scholar 

  • Shamir R, Phillip M, Levine A (2007) Growth retardation in pediatric Crohn’s disease: pathogenesis and interventions. Inflamm Bowel Dis 13:620–628

    Article  PubMed  Google Scholar 

  • Sheth SG, LaMont JT (1998) Toxic megacolon. Lancet 351:509–513

    Article  PubMed  CAS  Google Scholar 

  • Szavay P, Melter M, Hubert O, Pasternak I, Petersen C (1998) Komplikationen bei Kindern mit Colitis ulcerosa nach totaler Kolektomie und J-Pouch-Anlage. [Complications in children with ulcerative colitis after total colectomy and J-pouch]. Langenbecks Arch Chir Suppl Kongressbd 115:478–481)

    PubMed  CAS  Google Scholar 

  • Walker TR, Land ML, Kartashov A, Saslowsky TM, Lyerly DM, Boone JH, Rufo PA (2007) Fecal lactoferrin is a sensitive and specific marker of disease activity in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 44:414–422

    Article  PubMed  CAS  Google Scholar 

  • Wong AK, Kerkoutian S, Said J, Rashidi H, Pullarkat ST (2012) Risk of lymphoma in patients receiving antitumor necrosis factor therapy: a meta-analysis of published randomized controlled studies. Clin Rheumatol 31:631–636

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Regensburg, Pruefeninger Straße 86, 93049, Regensburg, Deutschland

    T. Lang

  2. Kinderchirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    B. Ure

  3. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland

    M. Melter

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  1. Kinderchirurgische Klinik, Universitätsklinikum München Dr. von Haunersches Kinderspital, München, Germany

    Dietrich von Schweinitz

  2. Abt. Kinderchirurgie, Medizinische Hochschule Hannover (MHH) Kinderklinik, Hannover, Germany

    Benno Ure

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Lang, T., Ure, B., Melter, M. (2013). Chronisch-entzündliche Darmerkrankungen. In: von Schweinitz, D., Ure, B. (eds) Kinderchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29779-3_34

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