Motivation
High-throughput sequencing now allows researchers to identify patterns of rearrangement in tumour genomes, and has led to the discovery of Complex Genomic Rearrangements (CGRs) as a new cytogenetic feature of some cancers. Closed chain breakage and rejoining (CCBR), a generalization of reciprocal translocation, was recently identified in prostate cancer [4]. CCBRs involve the balanced rearrangement of some n loci, and thus have the potential to fuse or interrupt up to n genes. In addition, dispersed throughout some breast cancer genomes are ‘genomic shards’, small fragments of DNA originating from elsewhere in the genome and inserted at the breakpoints of larger scale rearrangements.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bignell, G.R., et al.: Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome. Res. 17, 1296–1303 (2007)
Stephens, P.J., et al.: Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462, 1005–1010 (2009)
Galante, P., et al.: Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same indiv. Nucl. Acids Res. 39, 6056–6068 (2011)
Berger, M.F., et al.: The genomic complexity of primary human prostate cancer. Nature 470, 214–220 (2011)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
McPherson, A., Wu, C., Wyatt, A., Shah, S., Collins, C., Sahinalp, S.C. (2012). Discovery of Complex Genomic Rearrangements in Cancer Using High-Throughput Sequencing. In: Chor, B. (eds) Research in Computational Molecular Biology. RECOMB 2012. Lecture Notes in Computer Science(), vol 7262. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29627-7_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-29627-7_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-29626-0
Online ISBN: 978-3-642-29627-7
eBook Packages: Computer ScienceComputer Science (R0)