Abstract
This chapter gives a concise overview of potential industrial applications for terahertz imaging that have been reported over the past decade with a discussion of the major advantages and limitations of each approach. In the second half of the chapter we discuss in more detail how terahertz imaging can be used to investigate the microstructure of pharmaceutical dosage forms. A particular focus in this context is the nondestructive measurement of the coating thickness of polymer coated tablets, both by means of high resolution offline imaging in research and development as well as for in-line quality control during production.
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Notes
- 1.
The signal base is the part of the signal that corresponds to terahertz wave propagation through the coating layer (between peaks) or deeper into the tablet matrix (after the last peak). Ideally, it should be flat so that peaks can be identified easily.
- 2.
In all figures in this chapter the time delay is quoted in mm optical delay with \(n_\mathrm{air } = 1\).
References
B. Hu, M. Nuss, Opt. Lett. 20(16), 1716 (1995)
D. Mittleman, R. Jacobsen, M.C. Nuss, IEEE J. Sel. Top. Quantum Electron. 2(3), 679 (1996)
D. Mittleman, S. Hunsche, L. Boivin, M. Nuss, Opt. Lett. 22(12), 904 (1997)
D. Mittleman, M. Gupta, R. Neelamani, R. Baraniuk, J. Rudd, M. Koch, Appl. Phys. B Lasers Opt. 68(6), 1085 (1999)
J.B. Jackson, M. Mourou, J. Labaune, J.F. Whitaker, I.N.I. Duling, S.L. Williamson, C. Lavier, M. Menu, G.A. Mourou, Meas. Sci. Technol. 20(7), 075502–075511 (2009)
C. Jansen, S. Wietzke, O. Peters, M. Scheller, N. Vieweg, M. Salhi, N. Krumbholz, C. Jördens, T. Hochrein, M. Koch, Appl. Opt. 49(19), E48 (2010)
J.A. Zeitler, P.F. Taday, D.A. Newnham, M. Pepper, K.C. Gordon, T. Rades, J. Pharm. Pharmacol. 59(2), 209 (2007)
J.A. Zeitler, L.F. Gladden, Eur. J. Pharm. Biopharm. 71(1), 2 (2009)
Y.C. Shen, Int. J. Pharm. 417, 48 (2011)
B. Ferguson, X. Zhang, Nat. Mater. 1(1), 26 (2002)
D. Mittleman (ed.), Sensing with Terahertz Radiation. Springer Series in Optical Sciences Series, (Springer, Berlin, 2003)
K. Kawase, Opt. Photonics News 15(10), 34 (2004)
W. Chan, J. Deibel, D. Mittleman, Rep. Prog. Phys. 70(8), 1325 (2007)
M. Tonouchi, Nat. Photonics 1(2), 97 (2007)
S. Dexheimer (ed.), Terahertz Spectroscopy: Principles and Applications. Optical Science and Engineering, (CRC Press, Boca Raton, 2007)
I. Duling, D. Zimdars, Nat. Photonics 3, 630 (2009)
Y.S. Lee, Principles of Terahertz Science and Technology (Springer, New York, 2009)
P.U. Jepsen, D.G. Cooke, M. Koch, Laser Photonics Rev. 5(1), 124 (2010)
M. Walther, B.M. Fischer, A. Ortner, A. Bitzer, A. Thoman, H. Helm, Anal. Bioanal. Chem. 397(3), 1009 (2010)
J.A. Zeitler, Y. Shen, C. Baker, P.F. Taday, M. Pepper, T. Rades, J. Pharm Sci. 96(2), 330 (2007)
N. Krumbholz, T. Hochrein, N. Vieweg, T. Hasek, K. Kretschmer, M. Bastian, M. Mikulics, M. Koch, Polym. Testing 28(1), 30 (2009)
D. Zimdars, I. Duling, G. Fichter, J. White, AIP Conf. Proc. 1211(1), 564 (2010)
R.K. May, M.J. Evans, S. Zhong, I. Warr, L.F. Gladden, Y. Shen, J.A. Zeitler, J. Pharm Sci. 100(4), 1535 (2011)
L. Cartz, Nondestructive testing (ASM International Materials Park, Ohio, 1995)
C. Hellier, Handbook of nondestructive evaluation (McGraw-Hill, New York, 2001)
M. Soleimani, R. Bayford, Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 367(1900), 3017 (2009)
D. Ensminger, L. Bond, Ultrasonics: fundamentals, technologies and applications, 3rd edn. Mechanical Engineering, (Taylor and Francis, Boca Raton, 2009)
D. Stifter, Appl. Phys. B Lasers Opt. 88(3), 337 (2007)
I. Pupeza, R. Wilk, M. Koch, Opt. Express 15(7), 4335 (2007)
R. Wilk, I. Pupeza, R. Cernat, M. Koch, I. Pupeza, R. Cernat, IEEE J. Sel. Top. Quant. Electron. 14(2), 392 (2008)
M. Walther, B. Fischer, P.U. Jepsen, Chem. Phys. 288(2–3), 261 (2003)
B. Fischer, M. Hoffmann, H. Helm, R. Wilk, F. Rutz, T. Kleine-Ostmann, M. Koch, P. Jepsen, Opt. Express 13(14), 5205 (2005)
C.J. Strachan, T. Rades, D.A. Newnham, K.L. Gordon, M. Pepper, P.F. Taday, Chem. Phys. Lett. 390(1–3), 20 (2004)
Y. Shen, P.F. Taday, D.A. Newnham, M. Pepper, Semicond. Sci. Tech. 20(7), S254 (2005)
Y. Shen, P.F. Taday, D.A. Newnham, M. Kemp, M. Pepper, R. Hwu, K. Linden, Terahertz and Gigahertz Electronics and Photonics IV (SPIE Press, California, 2005), pp. 24–31
K. Yamamoto, M. Yamaguchi, M. Tani, M. Hangyo, S. Teramura, T. Isu, N. Tomita, Appl. Phys. Lett. 85(22), 5194 (2004)
D. Banerjee, W. von Spiegel, M. Thomson, S. Schabel, H. Roskos, Opt. Express 16(12), 9060 (2008)
H. Zhang, K. Mitobe, N. Yoshimura, in International Symposium on Electrical Insulating Materials (ISEIM), (IEEE, 2008), pp. 87–90
P. Parasoglou, E.P.J. Parrott, J.A. Zeitler, J. Rasburn, H. Powell, L.F. Gladden, M.L. Johns, Terahertz Sci. Technol. 3, 172 (2010)
R. Cunnell, T. Luce, J. Collins, R. Rungsawang, J. Freeman, H. Beere, D.A. Ritchie, L.F. Gladden, M.L. Johns, J.A. Zeitler, in 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 (IEEE, 2009), pp. 1–2
E.P.J. Parrott, J.A. Zeitler, J. McGregor, S. Oei, H. Unalan, S. Tan, W. Milne, J. Tessonier, R. Schlogl, L.F. Gladden, J. Phys. Chem. C 113(24), 10554 (2009)
J. McGregor, Z. Huang, E.P.J. Parrott, J.A. Zeitler, K. Nguyen, J. Rawson, A. Carley, T. Hansen, J.P. Tessonnier, D. Su, D. Teschner, E. Vass, A. Knop-Gericke, R. Schlögl, L.F. Gladden, J. Catal. 269(2), 329 (2010)
M. de Silva, C. McElroy, J. McGregor, A. York, J.A. Zeitler, L.F. Gladden, in 35th International Conference on Infrared Millimeter and Terahertz Waves (IRMMW-THz), (2010), pp. 1–2
R. Arrigo, M. Havecker, S. Wrabetz, R. Blume, M. Lerch, J. McGregor, E.P.J. Parrott, J.A. Zeitler, L.F. Gladden, A. Knop-Gericke, R. Schlögl, D. Su, J. Am. Chem. Soc. (2010)
C. Jördens, M. Koch, Opt. Eng. 47(3), 037003 (2008)
D. Zimdars, J. Valdmanis, J. White, G. Stuk, S. Williamson, W. Winfree, E. Madaras, in AIP Conference Proceedings, (2005), pp. 570–577
H. Zhong, J. Xu, X. Xie, T. Yuan, R. Reightler, E. Madaras, X. Zhang, IEEE Sens. J. 5(2), 203 (2005)
R.F. Anastasi, E.I. Madaras, J.P. Seebo, S.W. Smith, J.K. Lomness, P.E. Hintze, C.C. Kammerer, W.P. Winfree, R.W. Russell, in Proceedings of the SPIE, (2007), pp. 1–6
D. Zimdars, G. Fichter, A. Chernovsky, in 33rd International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz 2008) (IEEE, 2008), pp. 1–3
Y. Morita, A. Dobroiu, K. Kawase, C. Otani, Opt. Eng. 44(1), (2005)
Y. Morita, A. Dobroiu, C. Otani, K. Kawase, J. Food Prot. 68(4), 833 (2005)
C. Jördens, M. Scheller, S. Wietzke, D. Romeike, C. Jansen, T. Zentgraf, K. Wiesauer, V. Reisecker, M. Koch, Compos. Sci. Technol 70(3), 472 (2010)
D. Zimdars, J. White, G. Fichter, A. Chernovsky, S.L. Williamson, Proc. SPIE 6949(1), 69490B (2008)
C. Chen, D. Lee, T. Pollock, J. Whitaker, Opt. Express 18(4), 3477 (2010)
P. Lopato, T. Chady, R. Sikora, Int. J. Comput. Math. Electr. Electron. Eng. (COMPEL) 30(4), 1260 (2011)
D.K. Hsu, K.H. Im, C.P. Chiou, D.J. Barnard, AIP Conf. Proc. 1335(1), 533 (2011)
Y. Cai, Z. Wang, R. Dias, D. Goyal, in Proceedings of the 60th Electronic Components and Technology Conference (ECTC) (2010), pp. 1309–1315
J.M. Chin, V. Narang, X. Zhao, M.Y. Tay, A. Phoa, V. Ravikumar, L.H. Ei, S.H. Lim, C.W. Teo, S. Zulkifli, M.C. Ong, M.C. Tan, Microelectron. Reliab. 51(9–11), 1440 (2011)
J. Obradovic, J. Collins, O. Hirsch, M.D. Mantle, M.L. Johns, L.F. Gladden, Polymer 48(12), 3494 (2007)
Q. Wu, T. Hewitt, X. Zhang, Appl. Phys. Lett. 69(8), 1026 (1996)
Z. Jiang, X. Zhang, Opt. Lett. 23(14), 1114 (1998)
M. Usami, T. Iwamoto, R. Fukasawa, M. Tani, M. Watanabe, K. Sakai, Phys. Med. Biol. 47(21), 3749 (2002)
M. Yamashita, M. Usami, K. Fukushima, R. Fukasawa, C. Otani, K. Kawase, Appl. Opt. 44(25), 5198 (2005)
M. Usami, M. Yamashita, K. Fukushima, C. Otani, K. Kawase, Appl. Phys. Lett. 86(14), 3 (2005)
T. Yasuda, T. Yasui, T. Araki, E. Abraham, Opt. Commun. 267(1), 128 (2006)
T. Yasuda, Y. Kawada, H. Toyoda, H. Takahashi, Opt. Express 15(23), 15583 (2007)
A. Lee, Q. Hu, Opt. Lett. 30(19), 2563 (2005)
R. Kohler, A. Tredicucci, F. Beltram, H. Beere, E.H. Linfield, A. Davies, D.A. Ritchie, R. Iotti, F. Rossi, Nature 417(6885), 156 (2002)
A.W.M. Lee, B.S. Wil, S. Kumar, Q. Hu, J.L. Reno, IEEE Photon. Technol. Lett. 18(13), 1415 (2006)
P. Dean, N.K. Saat, S.P. Khanna, M. Salih, A. Burnett, J. Cunningham, E.H. Linfield, A.G. Davies, Opt. Express 17(23), 20631 (2009)
K. Nguyen, M.L. Johns, L.F. Gladden, C. Worrall, P. Alexander, H. Beere, M. Pepper, D.A. Ritchie, J. Alton, S. Barbieri, E. Linfield, Opt. Express 14(6), 2123 (2006)
F. Clarke, Vib. Spectrosc. 34(1), 25 (2004)
V. Busignies, B. Leclerc, P. Porion, P. Evesque, G. Couarraze, P. Tchoreloff, Eur. J. Pharm. Biopharm. 64(1), 38 (2006)
J. Aaltonen, K.C. Gordon, C.J. Strachan, T. Rades, Int. J. Pharm. 364(2), 159 (2008)
C. McGoverin, T. Rades, K.C. Gordon, J. Pharm Sci. 97(11), 4598 (2008)
A.J. Fitzgerald, B.E. Cole, P.F. Taday, J. Pharm Sci. 94(1), 177 (2005)
D. Auston, Appl. Phys. Lett. 26(3), 101 (1975)
D. Auston, K. Cheung, P. Smith, Appl. Phys. Lett. 45(3), 284 (1984)
Y. Shen, P.F. Taday, IEEE J. Sel. Top. Quantum Electron. 14(2), 407 (2008)
J.R. Fletcher, G.P. Swift, D. Dai, J.M. Chamberlain, P.C. Upadhya, J. Appl. Phys. 102(11), 113105 (2007)
W. Withayachumnankul, H. Lin, S. Mickan, B. Fischer, D. Abbott, in Photonic Materials, Devices, and Applications II (Maspalomas, Gran Canaria, 2007)
W. Withayachumnankul, B. Fischer, H. Lin, D. Abbott, J. Opt. Soc. Am. B 25(6), 1059 (2008)
V. Wallace, P.F. Taday, A.J. Fitzgerald, R. Woodward, J. Cluff, R. Pye, D.A. Arnone, Faraday Discuss. 126, 255 (2004)
B. Ferguson, D. Abbott, Microelectr. J. 32(12), 943 (2001)
R. Neelamani, H. Choi, R. Baraniuk, IEEE Trans. Signal Process. 52(2), 418 (2004)
D.L. Donoho, IEEE Trans. Inf. Theory 41(3), 613 (1995)
Y. Chen, S. Huang, E. Pickwell-Macpherson, Opt. Express 18(2), 1177 (2010)
R. Woodward, B. Cole, V. Wallace, R. Pye, D.A. Arnone, E.H. Linfield, M. Pepper, Phys. Med. Biol. 47(21), 3853 (2002)
E. Pickwell, B.E. Cole, A.J. Fitzgerald, M. Pepper, V.P. Wallace, Phys. Med. Biol. 49(9), 1595 (2004)
I. Russe, D. Brock, K. Knop, P. Kleinbudde, J.A. Zeitler, in 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (Istanbul, 2012), p. 2
R. Palermo, R. Cogdill, S. Short, J. Drennen Iii, P. Taday, J. Pharma. Biomed. 46(1), 36 (2008)
R. May, L. Han, J. Alton, S. Zhong, J. Elliott, C. Byers, L. Gladden, M. Evans, Y. Shen, J. Zeitler, in 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 (IEEE, 2009), pp. 1–2
G.M. Jantzen, J.R. Robinson, in Modern pharmaceutics, ed. by C.T. Rhodes, G.S. Banker (CRC Press, New York, 2002), pp. 501–528
L. Ho, R. Mueller, M. Romer, K.C. Gordon, J. Heinamaki, P. Kleinebudde, M. Pepper, T. Rades, Y.C. Shen, C.J. Strachan, P.F. Taday, J.A. Zeitler, J. Controlled Release 119(3), 253 (2007)
L. Ho, R. Mueller, C. Krueger, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P.F. Taday, J.A. Zeitler, J. Pharm. Sci. 99(1), 392 (2010)
V. Malaterre, M. Pedersen, J. Ogorka, R. Gurny, N. Loggia, P. Taday, Eur. J. Pharm. Biopharm. 74(1), 21 (2009)
L. Ho, R. Mueller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P.F. Taday, J.A. Zeitler, J. Controlled Release 127(1), 79 (2008)
D. Brock, J.A. Zeitler, A.Funke, K. Knop, P. Kleinebudde, submitted to Int. J. Pharm. (2012)
S. Zhong, H. Shen, Y.C. Shen, J.A. Zeitler, L. Ho, M. Evans, P. Taday, M. Pepper, T. Rades, K.C. Gordon, R. Muller, P. Kleinebudde, in 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 (IEEE, 2009), pp. 1–2
J.M.A. Mauritz, R.S. Morrisby, R.S. Hutton, C.H. Legge, C.F. Kaminski, J. Pharm. Sci. 99(1), 385 (2010)
S. Zhong, Y.C. Shen, L. Ho, R.K. May, J.A. Zeitler, M. Evans, P.F. Taday, M. Pepper, T. Rades, K.C. Gordon, R. Mueller, P. Kleinebudde, Opt. Laser Eng. 49(3), 361 (2011)
L. Ho, R. Mueller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P.F. Taday, J.A. Zeitler, Eur. J. Pharm. Biopharm. 71(1), 117 (2009)
R. Cogdill, R. Forcht, Y. Shen, P. Taday, J. Pharm. Innov. (2), 29 (2007)
L. Maurer, H. Leuenberger, Int. J. Pharm. 370(1–2), 8 (2009)
J. Müller, D. Brock, K. Knop, J.A. Zeitler, P. Kleinebudde, Eur. J. Pharm. Biopharm. 80, 690–697 (2012)
M. Juuti, H. Tuononen, T. Prykäri, V. Kontturi, M. Kuosmanen, E. Alarousu, J. Ketolainen, R. Myllylä, K.-E. Peiponen, Meas. Sci. Technol. (1), 015301 (2009)
H. Tuononen, E. Gornov, J.A. Zeitler, J. Aaltonen, K.-E. Peiponen, Opt. Lett. 35(5), 631 (2010)
H. Tuononen, K. Fukunaga, M. Kuosmanen, J. Ketolainen, K.-E. Peiponen, Appl. Spectrosc. 64(1), 127 (2010)
I. Sinka, S. Burch, J. Tweed, J. Cunningham, Int. J. Pharm. 271(1–2), 215 (2004)
T. Hyde, L. Gladden, Polymer 39(4), 811 (1998)
S.G. Harding, M.L. Johns, S.R. Pugh, P.J. Fryer, L.F. Gladden, Food Addit. Contam. 14(6–7), 583 (2012)
A. Portieri, P.F. Taday, Y.C. Shen, in 58th Pittsburgh Conference on Analytical and Applied Spectroscopy, (PITTCON 2007) (Chicago, USA, 2007)
J. Siepmann, Adv. Drug Deliv. Rev. 48(2–3), 139 (2001)
S. Kazarian, K. Chan, Macromolecules 36(26), 9866 (2003)
Y.Y. Chen, Hughes, L. P., L.F. Gladden, M.D. Mantle, J. Pharm Sci. 99(8), 3462 (2010)
J. Spencer, Z. Gao, T. Moore, L. Buhse, P.F. Taday, D.A. Newnham, Y. Shen, A. Portieri, A. Husain, J. Pharm. Sci. 97(4), 1543 (2008)
L. Ho, R. Mueller, K.C. Gordon, P. Kleinebudde, M. Pepper, T. Rades, Y. Shen, P.F. Taday, J.A. Zeitler, J. Pharm. Sci. 98(12), 4866 (2009)
L. Ho, Y. Cuppok, S. Muschert, K. Gordon, M. Pepper, Y. Shen, F. Siepmann, J. Siepmann, P. Taday, T. Rades, Int. J. Pharm. 382(1–2), 151 (2009)
R. Cogdill, S. Short, R. Forcht, Z. Shi, Y. Shen, P. Taday, C. Anderson, J. Drennen, J. Pharm. Innov. 1(1), 63 (2006)
B. Fischer, M. Hoffmann, H. Helm, G. Modjesch, P.U. Jepsen, Semicond. Sci. Tech. 20(7), S246 (2005)
E.N. Lewis, P.J. Treado, R.C. Reeder, G.M. Story, A.E. Dowrey, C. Marcott, I.W. Levin, Anal. Chem. 67(19), 3377 (2012)
J.L. Koenig, S.Q. Wang, R. Bhargava, Anal. Chem. 73(13), 360A (2001)
F.C. Clarke, M.J. Jamieson, D.A. Clark, S.V. Hammond, R.D. Jee, A.C. Moffat, Anal. Chem. 73(10), 2213 (2001)
J.A. Zeitler, D.A. Newnham, P.F. Taday, T.L. Threlfall, R.W. Lancaster, R.W. Berg, C.J. Strachan, M. Pepper, K.C. Gordon, T. Rades, J. Pharm. Sci. 95(11), 2486 (2006)
E.P.J. Parrott, J.A. Zeitler, T. Friscic, M. Pepper, W. Jones, G.M. Day, L.F. Gladden, Cryst. Growth Des. 9(3), 1452 (2009)
R. Li, J.A. Zeitler, D. Tomerini, E.P.J. Parrott, L.F. Gladden, G.M. Day, Phys. Chem. Chem. Phys. 12(20), 5329 (2010)
P.F. Taday, I. Bradley, D.A. Arnone, M. Pepper, J. Pharm. Sci. 92(4), 831 (2003)
C.J. Strachan, P.F. Taday, D.A. Newnham, K.C. Gordon, J.A. Zeitler, M. Pepper, T. Rades, J. Pharm. Sci. 94(4), 837 (2005)
J.A. Zeitler, D.A. Newnham, P.F. Taday, C.J. Strachan, M. Pepper, K.C. Gordon, T. Rades, Thermochim. Acta 436(1–2), 71 (2005)
J.A. Zeitler, K. Kogermann, J. Rantanen, T. Rades, P.F. Taday, M. Pepper, J. Aaltonen, C.J. Strachan, Int. J. Pharm. 334(1–2), 78 (2007)
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The authors would like to thank Ms. Bee Yin Yeo for her help in putting together Sect. 18.3.3 of this chapter.
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Zeitler, J.A., Shen, YC. (2012). Industrial Applications of Terahertz Imaging. In: Peiponen, KE., Zeitler, A., Kuwata-Gonokami, M. (eds) Terahertz Spectroscopy and Imaging. Springer Series in Optical Sciences, vol 171. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29564-5_18
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