Chronic Lymphocytic Leukemia

  • Anton W. Langerak
  • Yorick Sandberg
Part of the Principles and Practice book series (PRINCIPLES)


Human chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the Western world. CLL has long been believed to be a single disease, but recent insights underline the biological and clinical heterogeneity of CLL. Recognition of CLL subgroups with a completely different pathophysiology and clinical course, has paved the way to better define high-risk CLL patients based on prognostic factors, to predict response to therapy, and to estimate progression-free and overall survival. Moreover, knowledge of different aspects of the (immuno) pathogenesis of CLL (genomic and epigenetic aberrations, antigenic stimulation, microenvironmental stimuli) has greatly increased. These insights are key to further develop preventive strategies and to design innovative therapeutic strategies.


Chronic Lymphocytic Leukemia TP53 Mutation Chronic Lymphocytic Leukemia Patient Chronic Lymphocytic Leukemia Cell IGHV Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Immunology, Erasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands
  2. 2.Department of Internal Medicine, Erasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands

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