Molecular Biology and Classification of Multiple Myeloma

Chapter
Part of the Principles and Practice book series (PRINCIPLES)

Abstract

In recent years, significant progress has been made in understanding the molecular pathogenesis of multiple myeloma (MM). MM is characterized by the sequential multistage progressive accumulation of genetic abnormalities which lead to deregulation of key regulatory pathways. Numeric chromosomal abnormalities are present in almost all MM patients. Primary translocations occur early in MM pathogenesis, whereas secondary translocations are involved in progression. Chromosomal abnormalities include full or partial deletion of chromosome 13 and 17, amplification of chromosome 1, and recurrent 14q32 translocations. Hyperdiploidy is present in 45 % of patients. From the clinical point of view, the knowledge of MM molecular biology is important in making decisions about therapeutic choices and in designing novel molecule targeted drugs.

Keywords

Multiple Myeloma Myeloma Cell Line Immunoglobulin Heavy Chain Plasma Cell Leukemia Light Chain Lambda 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Haematooncology and Bone Marrow TransplantationMedical University of Lublin LublinPoland

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