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Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia

  • Agata A. Filip
  • Marta Libura
  • Sebastian Giebel
  • Olga Haus
Chapter
Part of the Principles and Practice book series (PRINCIPLES)

Abstract

Acute myeloid leukemia (AML) constitutes a group of diseases heterogeneous with regard to clinical course, response to therapy as well as genetic features that contribute to disease pathogenesis, progression, and outcome. Numerous molecular lesions found in AML patients serve as prognostic and predictive factors; some of these markers have been included in the latest WHO classification. The analysis of cryptic genomic changes and alterations of gene expression is particularly important in cytogenetically normal AML patients. NPM1 and biallelic CEBPA mutations are favorable prognostic factors, while MLL and FLT3 duplications, WT1, IDH1/IDH2, KIT, TET2, and DNMT3A mutations, as well as overexpression of BAALC, ERG, or MN1 have an adverse prognostic impact. Aside from aberrations involving structural genes, mutations of microRNAs, copy number alterations, and altered methylation of gene promoter regions also influence the development and progression of AML.

Keywords

Acute Myeloid Leukemia Disseminate Intravascular Coagulation Acute Promyelocytic Leukemia Minimal Residual Disease Acute Myeloid Leukemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank Dorothy Michalowski for proofreading and editing assistance.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Agata A. Filip
    • 1
  • Marta Libura
    • 2
  • Sebastian Giebel
    • 3
  • Olga Haus
    • 4
    • 5
  1. 1.Department of Cancer GeneticsMedical University of LublinLublinPoland
  2. 2.Department of Hematology, Oncology and Internal MedicineMedical University of WarsawWarsawPoland
  3. 3.Department of Bone Marrow TransplantationMaria Skłodowska-Curie Memorial Cancer Center and Institute of OncologyGliwicePoland
  4. 4.Department of Clinical GeneticsLudwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in ToruńBydgoszczPoland
  5. 5.Department of HematologyWrocław Medical UniversityWrocławPoland

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