Cytogenetics in Hematology

  • Olga Haus
  • Anna Poluha
  • Katarzyna Skonieczka
Part of the Principles and Practice book series (PRINCIPLES)


According to European LeukemiaNet—Workpackage Cytogenetics, cytogenetic analysis is mandatory to correctly diagnose and classify hematologic malignancies. Conventional cytogenetic analysis, which enables detection of both balanced and unbalanced chromosomal rearrangements, is still regarded as the gold standard of genetic diagnostics in hemato-oncology. However, a variety of rapidly developing state-of-the-art molecular and cyto-molecular techniques can now be applied, complementing the process of detection and analysis of recurrent genetic aberrations. Cytogenetics is currently recognized as an essential part of diagnostic process in hematologic malignancies. It helps to define specific disease entities, provides important prognostic and predictive information, influences therapy by setting the basis for individual treatment options that target cancer specific genetic abnormalities or their products, as well as helps to assess therapy effectiveness by indicating genetic remission or progression.


Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Hematologic Malignancy Comparative Genomic Hybridization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Ewa Duszeńko and Anna Jaśkowiec for their impressive cytogenetic work.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Clinical Genetics, Collegium Medicum in BydgoszczNicolaus Copernicus University in ToruńToruńPoland
  2. 2.Department of Hematology, Oncology, and Bone Marrow TransplantationMedical UniversityWrocławPoland
  3. 3.Department of Pediatric Hematology, Oncology and TransplantologyChildren’s University HospitalLublinPoland

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