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Molecular Biology of Acute Lymphoblastic Leukemia

  • Małgorzata Dawidowska
  • Monika D. Kraszewska
  • Katarzyna Derwich
  • Tomasz Szczepański
Chapter
Part of the Principles and Practice book series (PRINCIPLES)

Abstract

Acute lymphoblastic leukemia (ALL) is the most common but also the most successfully treated malignancy in children. Current cure rates of approximately 85 % have been reached through multi-agent therapeutic regimens and particularly through risk-stratification enabling therapy individualization. Nevertheless, relapse is still the main cause of treatment failure. Therefore, the main effort is now focused on improving the outcome of high risk ALL subtypes, i.e., Ph + ALL, infant ALL, ALL with MLL gene rearrangements, hypodiploid ALL, some T-ALL subsets, recurrent and refractory leukemia. Recent research using advanced molecular techniques, in particular microarray-based genomic gene expression profiling (GEP) and high resolution single nucleotide polymorphism (SNP) microarray approaches, resulted in the identification of novel genetic factors with a potential impact on ALL classification and treatment. The main goal is now to translate these findings on ALL blast biology and those on pharmacogenetics of patient response to therapy into improved diagnostics, prognostic classification, and treatment of this malignancy.

Keywords

Acute Lymphoblastic Leukemia Minimal Residual Disease Gene Rearrangement Nijmegen Breakage Syndrome Prognostic Classification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This chapter was partly supported by the Ministry of Science and Higher Education, grant N N407 311 839.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Małgorzata Dawidowska
    • 1
  • Monika D. Kraszewska
    • 1
  • Katarzyna Derwich
    • 2
  • Tomasz Szczepański
    • 3
  1. 1.Department of Molecular and Clinical GeneticsInstitute of Human Genetics, Polish Academy of SciencesPoznańPoland
  2. 2.Department of Pediatric OncologyHematology and Transplantology, Poznań University of Medical SciencesPoznańPoland
  3. 3.Department of Pediatric Hematology and OncologyMedical University of SilesiaZabrzePoland

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