Perfusion Computed Tomography: A Non-invasive Technique to Early Evaluating the Therapeutic Effect of Radiotherapy for Primary Hepatic Cancer
Purpose: This study aims to investigate the quantitative metrics derived from perfusion computed tomography imaging for early evaluating the therapeutic effect of radiotherapy for primary hepatic cancer (PHC).
Methods and Materials: A total of thirty-one patients with single histologically proven PHC. All patients were examined with CT-perfusion technique pre-(1 d before radiotherapy) and post-treatment (1d after radiotherapy). The third and the fourth conventional contrast-enhance CT would be carried out in one month, two later for evaluating the response of radiotherapy according to Response Evaluation Criteria in Solid Tumors. Data were analyzed using a dedicated software which generated a parameters, assessed hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT), and permeability surface area product (PS), hepatic arterial index (HAI), hepatic artery perfusion (HAP), and portal vein perfusion (PVP).Compared the quantitative index with regress ratio of tumor, found out which one can early reflect the therapeutic effect of radiotherapy.