Perfusion Computed Tomography: A Non-invasive Technique to Early Evaluating the Therapeutic Effect of Radiotherapy for Primary Hepatic Cancer

  • Qiwen Duan
  • Wen Chen
  • Junhua Liu
  • Yingchun Duan
  • Jianhua Ren
  • Minghua Yu
Part of the IFMBE Proceedings book series (IFMBE, volume 39)

Abstract

Purpose: This study aims to investigate the quantitative metrics derived from perfusion computed tomography imaging for early evaluating the therapeutic effect of radiotherapy for primary hepatic cancer (PHC).

Methods and Materials: A total of thirty-one patients with single histologically proven PHC. All patients were examined with CT-perfusion technique pre-(1 d before radiotherapy) and post-treatment (1d after radiotherapy). The third and the fourth conventional contrast-enhance CT would be carried out in one month, two later for evaluating the response of radiotherapy according to Response Evaluation Criteria in Solid Tumors. Data were analyzed using a dedicated software which generated a parameters, assessed hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT), and permeability surface area product (PS), hepatic arterial index (HAI), hepatic artery perfusion (HAP), and portal vein perfusion (PVP).Compared the quantitative index with regress ratio of tumor, found out which one can early reflect the therapeutic effect of radiotherapy.

Keywords

Hepatic Blood Flow Response Evaluation Criterion Mean Transit Time Perfusion Compute Tomography Dedicated Software 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Qiwen Duan
    • 1
  • Wen Chen
    • 2
  • Junhua Liu
    • 3
  • Yingchun Duan
    • 4
  • Jianhua Ren
    • 1
  • Minghua Yu
    • 5
  1. 1.Departments of Clinical Oncology, Taihe hospitalHubei University of MedicineShiyanChina
  2. 2.Departments of Radiology, Taihe hospitalHubei University of MedicineShiyanChina
  3. 3.Taihe hospitalHubei University of MedicineShiyanChina
  4. 4.Renmin hospitalHubei University of MedicineShiyanChina
  5. 5.Institute of Basic Medical SciencesHubei University of MedicineShiyanChina

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