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Lensfree Computational Microscopy Tools for On-Chip Imaging of Biochips

  • Serhan O. Isikman
  • Waheb Bishara
  • Onur Mudanyali
  • Ting-Wei Su
  • Derek Tseng
  • Aydogan Ozcan
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

The use of optical imaging for medical diagnostics at the point of care (POC) has great potential, but is limited by cost and the need for highly trained personnel. To this end, the cost, complexity, and size of optical microscopy devices can be reduced through the use of computation. These techniques can perform particularly well at specific tasks such as cytometry, water quality management, and disease diagnostics. This chapter focuses on lensfree on-chip imaging techniques that are based on partially coherent digital in-line holography and are especially promising for imaging of biochips toward field-use and telemedicine applications. This emerging imaging platform discards most optical components that are found in traditional microscopes such as lenses and compensates for the lack of physical components in the digital domain. Widely available image sensors and abundant computational power are used to digitally process the acquired raw data to recover traditional microscope-like images with submicron resolution over large sample volumes within biochips.

Keywords

Axial Resolution Sensor Plane Illumination Angle Bayer Pattern Waterborne Parasite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Serhan O. Isikman
    • 1
  • Waheb Bishara
    • 1
  • Onur Mudanyali
    • 1
  • Ting-Wei Su
    • 1
  • Derek Tseng
    • 1
  • Aydogan Ozcan
    • 1
    • 2
  1. 1.Electrical Engineering DepartmentUniversity of CaliforniaLos AngelesUSA
  2. 2.California NanoSystems Institute, Bioengineering Department, Department of SurgeryUniversity of CaliforniaLos AngelesUSA

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