Systemic Disorders Affecting the Genital Skin

  • Alberto Rosenblatt
  • Homero Gustavo de Campos Guidi
  • Walter BeldaJr.


Several systemic diseases may become manifest in the genital region. A systematic approach to diagnosis, including careful review of the clinical history associated with a comprehensive knowledge of local and systemic signs and symptoms is paramount in order to properly manage these conditions. Furthermore, selecting the most adequate laboratory investigation to aid in the diagnosis, particularly in diseases with unusual etiology or presentation, is an important skill. In this Chapter, the systemic disorders that may affect the male genitalia are reviewed.


Erythema Multiforme Seborrheic Dermatitis Plexiform Neurofibroma Thromboangiitis Obliterans Pityriasis Rosea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Adam R, Katz S, Lee K, Jewett M, Kodama R (2004) Wegener’s granulomatosis of the penis: diagnosis and management. Can J Urol 11:2341–2343PubMedGoogle Scholar
  2. Agarwal MM, Singh SK, Mandal AK (2007) Penile gangrene in diabetes mellitus with renal failure: a poor prognostic sign of systemic vascular calciphylaxis. Indian J Urol 23:208–210PubMedGoogle Scholar
  3. Aktoz T, Kaplan M, Yalcin O, Atakan IH, Inci O (2008) Penile and scrotal involvement in Buerger’s disease. Andrologia 40:401–403PubMedGoogle Scholar
  4. Al Rajabi W, Venturini M, Sala R, Calzavara-Pinton P (2006) Wegener’s granulomatosis of the penis: genital presentation of systemic disease. Dermatology 212:370–372PubMedGoogle Scholar
  5. Allen DC, Walsh MY (1996) Malignant lymphoma of the scrotum and Wegener’s granulomatosis of the penis–genital presentation of systemic disease. Ulster Med J 65:169–172PubMedGoogle Scholar
  6. Aloi F, Modl G, Solaroli C (1995) Malignant schwannoma of the glans penis. Hautarzt 46:656–659PubMedGoogle Scholar
  7. Annam V, Inamadar AC, Palit A, Koppad M, Peerapur BV, Yelikar BR (2007) Genital ulcer caused by Penicillium marneffei in an HIV-infected patient. Sex Transm Infect 83:249–250PubMedGoogle Scholar
  8. Assier H, Bastuji-Garin S, Revuz J, Roujeau JC (1995) Erythema multiforme with mucous membrane involvement and Stevens-Johnson syndrome are clinically different disorders with distinct causes. Arch Dermatol 131:539–543PubMedGoogle Scholar
  9. Ault P, Cortes J, Koller C, Kaled ES, Kantarjian H (2002) Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. Leuk Res 26:881–884PubMedGoogle Scholar
  10. Aynaud O, Bergeron C (2004) Penile intraepithelial neoplasia. Prog Urol 14:100–104PubMedGoogle Scholar
  11. Aynaud O, Piron D, Barrasso R, Poveda JD (1998) Comparison of clinical, histological, and virological symptoms of HPV in HIV-1 infected men and immunocompetent subjects. Sex Transm Infect 74:32–34PubMedGoogle Scholar
  12. Barber TD, Al-Omar O, Poulik J, McLorie GA (2006) Testicular infarction in a 12-year-old boy with Wegener’s granulomatosis. Urology 67:846.e9–846.e10Google Scholar
  13. Barkley C, Badalament RA, Metz EN, Nesbitt J, Drago JR (1989) Coumarin necrosis of the penis. J Urol 141:946–948PubMedGoogle Scholar
  14. Barros R, Cavalcanti AG, Favorito LA (2008) Plexiforme neurofibroma with compromising of the penile function. Urology 71:546.e9–546.e10Google Scholar
  15. Batta AG, Gundian JC, Myers RP (1989) Neurofibromatosis presenting as perineal pain and urethral burning. Urology 33:138–140PubMedGoogle Scholar
  16. Bernardini ML, D’Angelo G, Oggiano N, Campanati A, Ficcadenti A, Coppa GV, Offidani A (2006) Erythema multiforme following live attenuated trivalent measles-mumps-rubella vaccine. Acta Derm Venereol 86:359–360PubMedGoogle Scholar
  17. Bhatty TA, Riaz K (2009) Calciphylaxis mimicking penile gangrene: a case report. Scientific World Journal 9:1355–1359PubMedGoogle Scholar
  18. Biggar RJ, Johnson BK, Musoke SS, Masembe JB, Silverstein DM, Warshow MM, Alexander S (1986) Severe illness associated with appearance of antibody to human immunodeficiency virus in an African. Br Med J (Clin Res Ed) 293:1210–1211Google Scholar
  19. Bjornberg A, Hellgren L (1962) Pityriasis rosea. A statistical, clinical, and laboratory investigation of 826 patients and matched healthy controls. Acta Derm Venereol Suppl (Stockh) 42(Suppl 50):1–68Google Scholar
  20. Bjornberg A, Tegner E (1999) Pityriasis rosea. In: Fitzpatrick TB, Freedberg IM, Eisen AZ et al (eds) Dermatology in general medicine. McGraw-Hill, New York, p 542Google Scholar
  21. Bories N, Becuwe C, Marcilly MC, Wolf F, Balme B, Thomas L (2007) Glans penis ulceration revealing Wegener’s granulomatosis. Dermatology 214:187–189PubMedGoogle Scholar
  22. Brandt LJ, Bernstein LH, Boley SJ, Frank MS (1982) Metronidazole therapy for perineal Crohn’s disease: a follow-up study. Gastroenterology 83:383–387PubMedGoogle Scholar
  23. Burgdorf W (1981) Cutaneous manifestations of Crohn’s disease. J Am Acad Dermatol 5:689–695PubMedGoogle Scholar
  24. Bush NC, Maxwell KM, Hamoui N, Colegrove P (2008) A case of systemic polyarteritis nodosa with spermatic cord involvement. Nat Clin Pract Urol 5:462–466PubMedGoogle Scholar
  25. Cacoub P, Terrier B (2009) Hepatitis B-related autoimmune manifestations. Rheum Dis Clin North Am 35:125–137PubMedGoogle Scholar
  26. Caliskan B, Guven A, Atabek C, Gok F, Demirbag S, Surer I (2009) Henoch-Schonlein purpura presenting with symptoms mimicking balanoposthitis. Pediatr Rep 1:e5PubMedGoogle Scholar
  27. Calza AM, Kinloch S, Mainetti C, Salomon D, Saurat JH (1991) Primary human immunodeficiency virus infection mimicking syphilis. J Infect Dis 164:615–616PubMedGoogle Scholar
  28. Carter PS, de Ruiter A, Whatrup C, Katz DR, Ewings P, Mindel A, Northover JM (1995) Human immuno­deficiency virus infection and genital warts as risk factors for anal intraepithelial neoplasia in homosexual men. Br J Surg 82:473–474PubMedGoogle Scholar
  29. Chang IH, Ha MS, Chi BH, Kown YW, Lee SJ (2010) Warfarin-induced penile necrosis in a patient with heparin-induced thrombocytopenia. J Korean Med Sci 25:1390–1393PubMedGoogle Scholar
  30. Chauveau D, Guittard J, Mehrenberger M, Pourrat J (2008) Kidney involvement in systemic necrotizing vasculitis. Rev Prat 58:499–506PubMedGoogle Scholar
  31. Chen TJ, Chou YC, Chen CH, Kuo TT, Hong HS (2006) Genital porokeratosis: a series of 10 patients and review of the literature. Br J Dermatol 155:325–329PubMedGoogle Scholar
  32. Chernosky ME (1986) Porokeratosis. Arch Dermatol 122:869–870PubMedGoogle Scholar
  33. Chiba M, Iizuka M, Horie Y, Masamune O (1997) Metastatic Crohn’s disease involving the penis. J Gastroenterol 32:817–821PubMedGoogle Scholar
  34. Chiewchanvit S, Mahanupab P, Hirunsri P, Vanittanakom N (1991) Cutaneous manifestations of disseminated Penicillium marneffei mycosis in five HIV-infected patients. Mycoses 34:245–249PubMedGoogle Scholar
  35. Chin-Hong PV, Palefsky JM (2005) Human papillomavirus anogenital disease in HIV-infected individuals. Dermatol Ther 18:67–76PubMedGoogle Scholar
  36. Chuh A, Zawar V, Lee A (2005) Atypical presentations of pityriasis rosea: case presentations. J Eur Acad Dermatol Venereol 19:120–126PubMedGoogle Scholar
  37. Chung AK, Michels V, Poland GA, King BF, Wojno KJ, Oesterling JE (1996) Neurofibromatosis with involvement of the prostate gland. Urology 47:448–451PubMedGoogle Scholar
  38. Chusid MJ, Dale DC, West BC, Wolff SM (1975) The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 54:1–27Google Scholar
  39. Cockburn AG, Krolikowski J, Balogh K, Roth RA (1980) Crohn disease of penile and scrotal skin. Urology 15:596–598PubMedGoogle Scholar
  40. Cohen MS (2004) HIV and sexually transmitted diseases: lethal synergy. Top HIV Med 12:104–107PubMedGoogle Scholar
  41. Corbett ST, Lennington JN, Chua AN, Gonzales ET Jr (2010) Stenosing ureteritis in a 7-year-old boy with Henoch-Schonlein purpura nephritis: a case report and review of the literature. J Pediatr Urol 6:538–542PubMedGoogle Scholar
  42. Cormio L, Sanguedolce F, Pentimone S, Perrone A, Annese P, Turri FP, Bufo P, Carrieri G (2009) Urethral corpus spongiosum amyloidosis presenting with urethrorrhagia during erection. J Sex Med 6:2915–2917PubMedGoogle Scholar
  43. Davin JC, Weening JJ (2003) Diagnosis of Henoch-Schonlein purpura: renal or skin biopsy? Pediatr Nephrol 18:1201–1203PubMedGoogle Scholar
  44. Deng Z, Ribas JL, Gibson DW, Connor DH (1988) Infections caused by Penicillium marneffei in China and Southeast Asia: review of eighteen published cases and report of four more Chinese cases. Rev Infect Dis 10:640–652PubMedGoogle Scholar
  45. DiGiovanna JJ, Robinson-Bostom L (2003) Ichthyosis: etiology, diagnosis, and management. Am J Clin Dermatol 4:81–95PubMedGoogle Scholar
  46. Donnithorne KJ, Atkinson TP, Hinze CH, Nogueira JB, Saeed SA, Askenazi DJ, Beukelman T, Cron RQ (2009) Rituximab therapy for severe refractory chronic Henoch-Schonlein purpura. J Pediatr 155:136–139PubMedGoogle Scholar
  47. Dore B, Duriez P, Grange Ph JA (1990) Granulomatose de Wegener ‘a localisation u’retro-penienne a propos d’un cas. Ann Urol (Paris) 24:256–258Google Scholar
  48. Drago F, Rebora A (1999) The new herpesviruses: emerging pathogens of dermatological interest. Arch Dermatol 135:71–75PubMedGoogle Scholar
  49. Drago F, Broccolo F, Rebora A (2009) Pityriasis rosea: an update with a critical appraisal of its possible herpesviral etiology. J Am Acad Dermatol 61:303–318PubMedGoogle Scholar
  50. Duvic M (1991) Papulosquamous disorders associated with human immunodeficiency virus infection. Dermatol Clin 9:523–530PubMedGoogle Scholar
  51. Ebo DG, Mertens AV, De Clerck LS, Gentens P, Daelemans R (1998) Relapse of Wegener’s granulomatosis presenting as a destructive urethritis and penile ulceration. Clin Rheumatol 17:239–241PubMedGoogle Scholar
  52. Edlin RS, Aaronson DS, Wu AK, Blaschko SD, Yang G, Erickson BA, McAninch JW (2010) Squamous cell carcinoma at the site of a Prince Albert’s piercing. J Sex Med 7:2280–2283PubMedGoogle Scholar
  53. Elliott FG, Eid TC, Lakey WH (1981) Genitourinary neurofibromas: clinical significance. J Urol 125:725–727PubMedGoogle Scholar
  54. el-Shiemy S, Nassar A, Mokhtar M, Mabrouk D (1987) Light and electron microscopic studies of pityriasis rosea. Int J Dermatol 26:237–239PubMedGoogle Scholar
  55. English JC 3rd, Patel PJ, Greer KE (2001) Sarcoidosis. J Am Acad Dermatol 44:725–743; quiz 744–726PubMedGoogle Scholar
  56. Escher JC, Stoof TJ, van Deventer SJ, van Furth AM (2002) Successful treatment of metastatic Crohn disease with infliximab. J Pediatr Gastroenterol Nutr 34:420–423PubMedGoogle Scholar
  57. Esslimani M, Serre I, Granier M, Robert M, Baldet P, Costes V (1999) Urogenital amyloidosis: clinico-pathological study of 8 cases. Ann Pathol 19:487–491PubMedGoogle Scholar
  58. Felten A, Lecompte T, Ferchal F, Agbalika F (1993) Primary HIV-1 infection associated with prominent genital ulcers. Genitourin Med 69:78–79PubMedGoogle Scholar
  59. Freyschmidt-Paul P, Hoffmann R, Konig A, Happle R (1999) Linear porokeratosis superimposed on disseminated superficial actinic porokeratosis: report of two cases exemplifying the concept of type 2 segmental manifestation of autosomal dominant skin disorders. J Am Acad Dermatol 41:644–647PubMedGoogle Scholar
  60. Gaines H, von Sydow M, Pehrson PO, Lundbegh P (1988) Clinical picture of primary HIV infection presenting as a glandular-fever-like illness. BMJ 297:1363–1368PubMedGoogle Scholar
  61. Garaffa G, Bettocchi C, Christopher N, Ralph D (2008) Plexiform neurofibroma of the penis associated with erectile dysfunction due to arterial steeling. J Sex Med 5:234–236PubMedGoogle Scholar
  62. Garcia FVMJ, Hernandez-Nunez A, Cordoba S, Fernandez-Herrera J, Garcia-Diez A (2004) Atypical pityriasis rosea and Hodgkin’s disease. J Eur Acad Dermatol Venereol 18:81–82Google Scholar
  63. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Sutton SA, Assa’ad AH, Rothenberg ME (2004) Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 113:115–119PubMedGoogle Scholar
  64. Giannarini G, Pomara G, Moro U, Mogorovich A, Menchini Fabris F, Morelli G, Scott CA, Selli C (2009) Isolated polyarteritis nodosa of the genitourinary tract presenting with severe erectile dysfunction: a case report with long-term follow-up. J Sex Med 6:1189–1193PubMedGoogle Scholar
  65. Gibson LE, el-Azhary RA (2000) Erythema elevatum diutinum. Clin Dermatol 18:295–299PubMedGoogle Scholar
  66. Giuffrida TJ, Kerdel FA (2002) Sarcoidosis. Dermatol Clin 20:435–447, viPubMedGoogle Scholar
  67. Gleich GJ, Leiferman KM, Pardanani A, Tefferi A, Butterfield JH (2002) Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet 359:1577–1578PubMedGoogle Scholar
  68. Goedert JJ, Cote TR, Virgo P, Scoppa SM, Kingma DW, Gail MH, Jaffe ES, Biggar RJ (1998) Spectrum of AIDS-associated malignant disorders. Lancet 351:1833–1839PubMedGoogle Scholar
  69. Gonzalez-Gay MA, Llorca J (2005) Controversies on the use of corticosteroid therapy in children with Henoch-Schonlein purpura. Semin Arthritis Rheum 35:135–137PubMedGoogle Scholar
  70. Gonzalez-Guerra E, Angulo J, Vargas-Machuca I, Farina Mdel C, Martin L, Requena L (2006) Cutaneous Crohn’s disease causing deformity of the penis and scrotum. Acta Derm Venereol 86:179–180PubMedGoogle Scholar
  71. Gray BK, Lockhartmummery HE, Morson BC (1965) Crohn’s disease of the anal region. Gut 6:515–524PubMedGoogle Scholar
  72. Gubinelli E, Cocuroccia B, Lazzarotto T, Girolomoni G (2003) Nodular perianal herpes simplex with prominent plasma cell infiltration. Sex Transm Dis 30:157–159PubMedGoogle Scholar
  73. Hagensee ME, Cameron JE, Leigh JE, Clark RA (2004) Human papillomavirus infection and disease in HIV-infected individuals. Am J Med Sci 328:57–63PubMedGoogle Scholar
  74. Handisurya A, Rieger A, Bankier A, Koller A, Salat A, Stingl G, Kirnbauer R (2007) Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy. Br J Dermatol 157:788–794PubMedGoogle Scholar
  75. Harmanyeri Y, Taskapan O, Dogan B, Baloglu H, Basak M (1998) A case of coumarin necrosis with penile and pedal involvement. J Eur Acad Dermatol Venereol 10:248–252PubMedGoogle Scholar
  76. Harris CF, Mydlo JH (2003) Ischemia and gangrene of the penis. J Urol 169:1795PubMedGoogle Scholar
  77. Harten P, Muller-Huelsbeck S, Regensburger D, Loeffler H (1996) Multiple organ manifestations in thromboan­giitis obliterans (Buerger’s disease). A case report. Angiology 47:419–425PubMedGoogle Scholar
  78. Hey WD, Shienbaum AJ, Brown GA (2009) Sarcoidosis presenting as an epididymal mass. J Am Osteopath Assoc 109:609–610PubMedGoogle Scholar
  79. Hick RW, Prose N (2010) Penile erosions associated with foscarnet therapy in a child. Pediatr Dermatol 27:302–303PubMedGoogle Scholar
  80. Hidaka Y, Liu Y, Yamamoto M, Mori R, Miyazaki C, Kusuhara K, Okada K, Ueda K (1993) Frequent isolation of human herpesvirus 7 from saliva samples. J Med Virol 40:343–346PubMedGoogle Scholar
  81. High WA, Hoang MP, Stevens K, Cockerell CJ (2003) Late-stage nodular erythema elevatum diutinum. J Am Acad Dermatol 49:764–767PubMedGoogle Scholar
  82. Hillman RJ, Goldmeier D, Taylor-Robinson D (1990) Scrotal ulceration in HIV-positive patients. Genitourin Med 66:93–94PubMedGoogle Scholar
  83. Hilmarsdottir I, Coutellier A, Elbaz J, Klein JM, Datry A, Gueho E, Herson S (1994) A French case of laboratory-acquired disseminated Penicillium marneffei infection in a patient with AIDS. Clin Infect Dis 19:357–358PubMedGoogle Scholar
  84. Ho KL, Hayden MT (1979) Sarcoidosis of urethra simulating carcinoma. Urology 13:197–199PubMedGoogle Scholar
  85. Hornez E, Laroche J, Monchal T, Bourgouin S, Riviere P, Fournier R, Dantzer E (2010) Necrosis of the glans penis: a complication of an injection of buprenorphin in a opioid abuser. Ann Chir Plast Esthet 55:159–161PubMedGoogle Scholar
  86. Jackson S, Nesbitt L (2008) Differential diagnosis for the dermatologist. Springer, HeidelbergGoogle Scholar
  87. Jacobson MA (1992) Review of the toxicities of foscarnet. J Acquir Immune Defic Syndr 5(Suppl 1):S11–S17PubMedGoogle Scholar
  88. Jacyk WK (1980) Pityriasis rosea in Nigerians. Int J Dermatol 19:397–399PubMedGoogle Scholar
  89. Jayaweera DT (1997) Minimising the dosage-limiting toxicities of foscarnet induction therapy. Drug Saf 16:258–266PubMedGoogle Scholar
  90. Jimenez Rodriguez RM, Arguelles Solido E, Marcilla Plaza D, Gonzalez Resina R, Lozano Blasco JM, Campoy Martinez P (2006) Metastatic Crohn’s disease involving the penile foreskin. Arch Esp Urol 59:902–905PubMedGoogle Scholar
  91. Johns CJ, Michele TM (1999) The clinical management of sarcoidosis. A 50-year experience at the Johns Hopkins Hospital. Medicine (Baltimore) 78:65–111Google Scholar
  92. Kameyama K, Kuramochi S, Kamio N, Akasaka Y, Higa I, Hata J (1998) Isolated periarteritis nodosa of the spermatic cord presenting as a scrotal mass: report of a case. Heart Vessels 13:152–154PubMedGoogle Scholar
  93. Kandrotas RJ, Deterding J (1988) Genital necrosis secondary to warfarin therapy. Pharmacotherapy 8:351–354PubMedGoogle Scholar
  94. Karademir K, Senkul T, Atasoyu E, Yildirim S, Nalbant S (2005) Ulcerative necrosis of the glans penis resulting from polyarteritis nodosa. J Clin Rheumatol 11:167–169PubMedGoogle Scholar
  95. Katoulis AC, Liakou A, Bozi E, Theodorakis M, Alevizou A, Zafeiraki A, Mistidou M, Stavrianeas NG (2010) Erythema multiforme following vaccination for human papillomavirus. Dermatology 220:60–62PubMedGoogle Scholar
  96. Kaur S, Handa S (2008) Erythema multiforme following vaccination in an infant. Indian J Dermatol Venereol Leprol 74:251–253PubMedGoogle Scholar
  97. Kawsar M, Long S (2007) Localized amyloidosis of glans penis. Int J STD AIDS 18:720–721PubMedGoogle Scholar
  98. Kee KH, Lee MJ, Shen SS, Suh JH, Lee OJ, Cho HY, Ayala AG, Ro JY (2008) Amyloidosis of seminal vesicles and ejaculatory ducts: a histologic analysis of 21 cases among 447 prostatectomy specimens. Ann Diagn Pathol 12:235–238PubMedGoogle Scholar
  99. Khoriaty N, Schick E (1980) Penile gangrene: an unusual complication of priapism. How to avoid it? Urology 16:280–283PubMedGoogle Scholar
  100. Kinn AC, Hedenborg L (1977) Polyarteritis nodosa of the penis. Scand J Urol Nephrol 11:289–291PubMedGoogle Scholar
  101. Kitauchi T, Kagebayashi Y, Fujimoto K, Yoshida K, Ozono S, Hirao Y (2002) Erectile dysfunction arising from polyarteritis nodosa: a case report. Hinyokika Kiyo 48:663–666PubMedGoogle Scholar
  102. Klauder J (1924) Pityriasis rosea with particular reference to its unusual manifestations. JAMA 82:178–183Google Scholar
  103. Kluger N, Girard C, Guillot B, Bessis D (2010) Penile and scrotal skin necrosis after injection of crushed buprenorphine tablets. Presse Med 39:610–611PubMedGoogle Scholar
  104. Kojic EM, Cu-Uvin S (2007) Update: human papillomavirus infection remains highly prevalent and persistent among HIV-infected individuals. Curr Opin Oncol 19:464–469PubMedGoogle Scholar
  105. Kreuter A, Brockmeyer NH, Hochdorfer B, Weissenborn SJ, Stucker M, Swoboda J, Altmeyer P, Pfister H, Wieland U (2005) Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 52:603–608PubMedGoogle Scholar
  106. Kwok B, Varol C (2010) Priapism and penile gangrene due to thrombotic thrombocytopenic purpura. Urology 75:71–72PubMedGoogle Scholar
  107. Labardini MM, Kallet HA, Cerny JC (1967) Urogenital neurofibromatosis simulating an intersex problem. J Urol 98:627–632PubMedGoogle Scholar
  108. Laino L, Pala S, Innocenzi D, Accappaticcio G, Van Steensel MA (2004) Genital porokeratosis. Eur J Dermatol 14:190–192PubMedGoogle Scholar
  109. Lane VA, Vajda P, King D, Stahlschmidt J, Sugarman I, Subramaniam R (2010) Metastatic Crohn’s disease: two cases of penile Crohn’s and literature review. J Pediatr Urol 6:270–273PubMedGoogle Scholar
  110. Lapan DI, Graham AR, Bangert JL, Boyer JT, Conner WT (1980) Amyloidosis presenting as priapism. Urology 15:167–170PubMedGoogle Scholar
  111. Lebwohl M, Fleischmajer R, Janowitz H, Present D, Prioleau PG (1984) Metastatic Crohn’s disease. J Am Acad Dermatol 10:33–38PubMedGoogle Scholar
  112. Lehrnbecher T, Kontny HU, Jeschke R (1999) Metastatic Crohn’s disease in a 9-year-old boy. J Pediatr Gastroenterol Nutr 28:321–323PubMedGoogle Scholar
  113. Leiferman KM, Gleich GJ (2004) Hypereosinophilic syndrome: case presentation and update. J Allergy Clin Immunol 113:50–58PubMedGoogle Scholar
  114. Leiferman KM, Gleich GJ, Peters MS (2007) Dermatologic manifestations of the hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:415–441PubMedGoogle Scholar
  115. Lemster N, Neumark M, Arieh I (2010) Pityriasis rosea in a woman and her husband – case report and review of the literature. Case Rep Dermatol 2:135–139PubMedGoogle Scholar
  116. Levell NJ, Bewley AP, Levene GM (1994) Porokeratosis of Mibelli on the penis, scrotum and natal cleft. Clin Exp Dermatol 19:77–78PubMedGoogle Scholar
  117. Levy O, Tishler M (2009) Acquired ichthyosis as the primary manifestation of renal cell carcinoma. Isr Med Assoc J 11:121–122PubMedGoogle Scholar
  118. Levy JA, Ferro F, Greenspan D, Lennette ET (1990) Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 335:1047–1050PubMedGoogle Scholar
  119. Lim JH, Kim H (2009) Localized amyloidosis presenting with a penile mass: a case report. Cases J 2:160PubMedGoogle Scholar
  120. Loche F, Schwarze HP, Thedenat B, Carriere M, Bazex J (2000) Erythema multiforme associated with hepatitis B immunization. Clin Exp Dermatol 25:167–168PubMedGoogle Scholar
  121. Mahmood N, Afzal N, Joyce A (1997) Sarcoidosis of the penis. Br J Urol 80:155PubMedGoogle Scholar
  122. Makis A, Stavrou S, Chaliasos N, Zioga A, Vlahos AP, Gaitanis G, Siamopoulou A, Bassukas ID (2010) Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in a child, associated with a rotavirus infection: a case report. J Med Case Reports 4:281Google Scholar
  123. Mani S, Flynn SD, Duffy TP, Morgan W (1993) Isolated amyloidosis of the penile urethra and corpus spongiosum: a case report. J Urol 150:1915–1916PubMedGoogle Scholar
  124. Matsuda S, Mitsukawa S, Ishii N, Shirai M (1976) A case of Wegener’s granulomatosis with necrosis of the penis. Tohoku J Exp Med 118:145–151PubMedGoogle Scholar
  125. Matsui I, Tanimura M, Kobayashi N, Sawada T, Nagahara N, Akatsuka J (1993) Neurofibromatosis type 1 and childhood cancer. Cancer 72:2746–2754PubMedGoogle Scholar
  126. May LP, Kelly J, Sanchez M (1990) Hypereosinophilic syndrome with unusual cutaneous manifestations in two men with HIV infection. J Am Acad Dermatol 23:202–204PubMedGoogle Scholar
  127. Melbye M, Cote TR, Kessler L, Gail M, Biggar RJ (1994) High incidence of anal cancer among AIDS patients. The AIDS/Cancer Working Group. Lancet 343:636–639PubMedGoogle Scholar
  128. Mills JL Sr (2003) Buerger’s disease in the 21st century: diagnosis, clinical features, and therapy. Semin Vasc Surg 16:179–189PubMedGoogle Scholar
  129. Mireku-Boateng AO, Nwokeji C (2004) Sequelae of parenteral drug abuse involving the external genitalia. Urol Int 73:302–304PubMedGoogle Scholar
  130. Mizukawa Y, Shiohara T (2009) Fixed drug eruption: a prototypic disorder mediated by effector memory T cells. Curr Allergy Asthma Rep 9:71–77PubMedGoogle Scholar
  131. Mortell A, Amjad B, Breatnach F, Devaney D, Puri P (2007) Penile malignant peripheral nerve sheath tumour (schwannoma) in a three-year-old child without evidence of neurofibromatosis. Eur J Pediatr Surg 17:428–430PubMedGoogle Scholar
  132. Mosunjac M, Park J, Wang W, Tadros T, Siddiqui M, Bagirov M, Little J (2009) Genital and perianal herpes simplex simulating neoplasia in patients with AIDS. AIDS Patient Care STDS 23:153–158PubMedGoogle Scholar
  133. Mountain JC (1970) Cutaneous ulceration in Crohn’s disease. Gut 11:18–26PubMedGoogle Scholar
  134. Mulpuru SK, Gujja K, Pai VM, Chen CY, Levey RL (2008) A rare and unusual cause of PSA (prostate-specific antigen) elevation: sarcoidosis of the prostate. Am J Med Sci 335:246–248PubMedGoogle Scholar
  135. Muneer A, Ali I, Blick C, Turner G, Turner R (2009) An unusual solitary lesion on the glans penis. Clin Exp Dermatol 34:929–930PubMedGoogle Scholar
  136. Nelson JS, Stone MS (2000) Update on selected viral exanthems. Curr Opin Pediatr 12:359–364PubMedGoogle Scholar
  137. Neri I, Bardazzi F, Fanti PA, Guidetti MS (1995a) Penile Crohn’s disease: a case report. Genitourin Med 71:45–46PubMedGoogle Scholar
  138. Neri I, Marzaduri S, Passarini B, Patrizi A (1995b) Genital porokeratosis of Mibelli. Genitourin Med 71:410–411PubMedGoogle Scholar
  139. Neulander EZ, Lismer L, Kaneti J (2000) Necrosis of the glans penis: a rare complication of intravesical therapy with mitomycin c. J Urol 164:1306PubMedGoogle Scholar
  140. Orhan I, Onur R, Akpolat N, Semercioz A (2004) Penile amputation in Buerger’s disease-an unusual cause of organ loss. Scand J Urol Nephrol 38:188–189PubMedGoogle Scholar
  141. Parks AG, Morson BC, Pegum JS (1965) Crohn’s disease with cutaneous involvement. Proc R Soc Med 58: 241–242PubMedGoogle Scholar
  142. Parsons JM (1986) Pityriasis rosea update: 1986. J Am Acad Dermatol 15:159–167PubMedGoogle Scholar
  143. Pascual-Castroviejo I, Lopez-Pereira P, Savasta S, Lopez-Gutierrez JC, Lago CM, Cisternino M (2008) Neurofibromatosis type 1 with external genitalia involvement presentation of 4 patients. J Pediatr Surg 43:1998–2003PubMedGoogle Scholar
  144. Pennesi M, Biasotto E, Saccari A (2006) Schonlein-Henoch purpura involving the penis. Arch Dis Child 91:603PubMedGoogle Scholar
  145. Perez-Carmona L, Aguayo-Leiva I, Gonzalez-Garcia C, Jaen-Olasolo P (2010) The quadrivalent human papillomavirus vaccine: erythema multiforme and cutaneous side effects after administration. Dermatology 221:197–200PubMedGoogle Scholar
  146. Pillebout E, Nochy D, Thervet E (2009) Henoch-Shonlein purpura. Nephrol Ther 5:663–675PubMedGoogle Scholar
  147. Porter WM, Du PMH, Philip G, Bunker CB (2001) Porokeratosis of the penis. Br J Dermatol 144:643–644PubMedGoogle Scholar
  148. Rajpara SM, Siddha SK, Ormerod AD, Kerr KM, Kolhe PS (2008) Cutaneous penile and perianal Crohn’s disease treated with a combination of medical and surgical interventions. Australas J Dermatol 49:21–24PubMedGoogle Scholar
  149. Rasi A, Tajziehchi L, Savabi-Nasab S (2008) Oral erythromycin is ineffective in the treatment of pityriasis rosea. J Drugs Dermatol 7:35–38PubMedGoogle Scholar
  150. Rehman J, Rizkala ER, Chughtai B, Khan SA (2005) Hypoechoic testicular mass: a case of testicular and epididymal sarcoidosis. Urology 66:657PubMedGoogle Scholar
  151. Rink RC, Mitchell ME (1983) Genitourinary neurofibromatosis in childhood. J Urol 130:1176–1179PubMedGoogle Scholar
  152. Ritter M, Nawab RA, Tannenbaum M, Hakky SI, Morgan MB (2003) Localized amyloidosis of the glans penis: a case report and literature review. J Cutan Pathol 30:37–40PubMedGoogle Scholar
  153. Rizzato G, Fraioli P, Montemurro L (1995) Nephrolithiasis as a presenting feature of chronic sarcoidosis. Thorax 50:555–559PubMedGoogle Scholar
  154. Rodo J, Medina M, Carrasco R, Morales L (1999) Enlarged penis due to a plexiform neurofibroma. J Urol 162:1753–1754PubMedGoogle Scholar
  155. Ronco P, Mignon F, Laneo Y, Roland J, Morel-Maroger L, Gattegno B (1982) Ureteral stenosis in Wegener’s granulomatosis. Report of a case. Nephron 30:201–204PubMedGoogle Scholar
  156. Rosenblatt A, Campos Guidi H (2009) Human papillomavirus infection in HIV-infected individuals. In: Rosenblatt A, Campos Guidi H (eds) Human papillomavirus-a practical guide for urologists. Springer, HeidelbergGoogle Scholar
  157. Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159:1211–1218PubMedGoogle Scholar
  158. Rubinstein I, Baum GL, Hiss Y (1986) Sarcoidosis of the penis: report of a case. J Urol 135:1016–1017PubMedGoogle Scholar
  159. Rubio FA, Robayna G, Herranz P, De Lucas R, Garcia-Jimenez JA, Casado M (1999) Necrotizing vasculitis of the glans penis. Br J Dermatol 140:756–757PubMedGoogle Scholar
  160. Saha M, Edmonds E, Martin J, Bunker CB (2009) Penile lymphoedema in association with asymptomatic Crohn’s disease. Clin Exp Dermatol 34:88–90PubMedGoogle Scholar
  161. Sandilands A, Terron-Kwiatkowski A, Hull PR, O’Regan GM, Clayton TH, Watson RM, Carrick T, Evans AT, Liao H, Zhao Y, Campbell LE, Schmuth M, Gruber R, Janecke AR, Elias PM, van Steensel MA, Nagtzaam I, van Geel M, Steijlen PM, Munro CS, Bradley DG, Palmer CN, Smith FJ, McLean WH, Irvine AD (2007) Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 39:650–654PubMedGoogle Scholar
  162. Sanli H, Akay BN, Sen BB, Kocak AY, Emral R, Bostanci S (2009) Acquired ichthyosis associated with type 1 diabetes mellitus. Dermatoendocrinol 1:34–36PubMedGoogle Scholar
  163. Segretain G (1959) Penicillium marneffei n. sp., agent d’une mycose du systeme reticuloendothelial. Mycopathol Mycol Appl 11:327–353Google Scholar
  164. Sharma PK, Yadav TP, Gautam RK, Taneja N, Satyanarayana L (2000) Erythromycin in pityriasis rosea: a double-blind, placebo-controlled clinical trial. J Am Acad Dermatol 42:241–244PubMedGoogle Scholar
  165. Shobhana A, Guha SK, Neogi DK (2004) Mucocutaneous manifestations of HIV infection. Indian J Dermatol Venereol Leprol 70:82–86PubMedGoogle Scholar
  166. Shum DT, Guenther L (1990) Metastatic Crohn’s disease. Case report and review of the literature. Arch Dermatol 126:645–648PubMedGoogle Scholar
  167. Singal A, Pandhi D, Rusia U (2007) Purpuric pityriasis rosea-like eruption: a cutaneous marker of acute myeloid leukaemia. J Eur Acad Dermatol Venereol 21:822–823PubMedGoogle Scholar
  168. Singh I, Joshi MK, Jaura MS (2010) Strangulation of penis by a ball bearing device. J Sex Med 7:3793–3797PubMedGoogle Scholar
  169. Slaney G, Muller S, Clay J, Sumathipala AH, Hillenbrand P, Thompson H (1986) Crohn’s disease involving the penis. Gut 27:329–333PubMedGoogle Scholar
  170. Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS (1993) Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest 91:1721–1730PubMedGoogle Scholar
  171. Somers WJ, Lowe FC (1986) Localized gangrene of the scrotum and penis: a complication of heroin injection into the femoral vessels. J Urol 136:111–113PubMedGoogle Scholar
  172. Soreide K (2005) Surgical management of nonrenal genitourinary manifestations in children with Henoch-Schonlein purpura. J Pediatr Surg 40:1243–1247PubMedGoogle Scholar
  173. Srinivasan V, Kehinde EO, Harris MD, Turner AG (1992) Localized amyloid of the glans penis. Br J Surg 79:1156PubMedGoogle Scholar
  174. Stamm WE, Handsfield HH, Rompalo AM, Ashley RL, Roberts PL, Corey L (1988) The association between genital ulcer disease and acquisition of HIV infection in homosexual men. JAMA 260:1429–1433PubMedGoogle Scholar
  175. Stein M, Anderson C, Ricciardi R, Chamberlin JW, Lerner SE, Glicklich D (1994) Penile gangrene associated with chronic renal failure: report of 7 cases and review of the literature. J Urol 152:2014–2016PubMedGoogle Scholar
  176. Stillwell TJ, DeRemee RA, McDonald TJ, Weiland LH, Engen DE (1987) Prostatic involvement in Wegener’s granulomatosis. J Urol 138:1251–1253PubMedGoogle Scholar
  177. Stucker F, Masouye I, Toutous-Trellu L (2006) Fever and penis ulcer in an 87-year-old man. Dermatology 212:397–398PubMedGoogle Scholar
  178. Tai PC, Ackerman SJ, Spry CJ, Dunnette S, Olsen EG, Gleich GJ (1987) Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease. Lancet 1:643–647PubMedGoogle Scholar
  179. Tan E, David N, Kinsey W, Levell NJ (2006) Recurrent painful ulcers on the penis. Clin Exp Dermatol 31: 317–318PubMedGoogle Scholar
  180. Thompson PD, Harty JI, Koper D (1992) Neurofibroma of penis. Urology 40:555–556PubMedGoogle Scholar
  181. Tu D, Rashid M, Orihuela E, Hunter GC (2005) Arterialization of deep dorsal vein of penis for penile ischemia. Urology 65:174PubMedGoogle Scholar
  182. Udompaetaikul M, Ophaswongse S, Palungwachira P (2001) Nodular cutaneous amyloidosis involving the glan penis: report of a case. J Med Assoc Thai 84:1065–1068PubMedGoogle Scholar
  183. UNAIDS (2010) Global report: UNAIDS report on the global AIDS epidemic, Joint United Nations Programme on HIV/AIDS (UNAIDS), ISBN 978-92-9173-871–7,
  184. Vandwalle J, Dugardin F, Petit T, Surga N, Paul A, Petit J (2007) Haemospermia due to seminal vesicle amyloidosis. Treatment by laparoscopic vesiculectomy. A case report. Prog Urol 17:1382–1384PubMedGoogle Scholar
  185. Vargas-Laguna E, Nagore E, Alfaro A, Botella-Estrada R, Sanmartin O, Requena C, Llombart B, Guillen C (2006) Monitoring the evolution of a localized type of porokeratosis using dermatoscopy. Actas Dermosifiliogr 97:77–78PubMedGoogle Scholar
  186. Vasu TS, Lai RS, Amzuta IG, Nasr MR, Lenox RJ (2006) Sarcoidosis presenting as intrascrotal mass: case report and review. South Med J 99:995–997PubMedGoogle Scholar
  187. Vella EJ, Waller DG (1981) Granulomatous vasculitis of the penis with glomerulonephritis. Postgrad Med J 57:262–264PubMedGoogle Scholar
  188. Vitenson JH, Wilson JM (1972) Sarcoid of the glans penis. J Urol 108:284–289PubMedGoogle Scholar
  189. Wallach D (2005) Neutrophilic dermatoses. Rev Med Interne 26:41–53PubMedGoogle Scholar
  190. Watanabe K, Nanki T, Sugihara T, Miyasaka N (2008) A case of polyarteritis nodosa with periurethralaseptic abscesses and testicular lesions. Clin Exp Rheumatol 26:1113–1115PubMedGoogle Scholar
  191. Wei H, Friedman KA, Rudikoff D (2000) Multiple indurated papules on penis and scrotum. J Cutan Med Surg 4:202–204PubMedGoogle Scholar
  192. Whittaker M, Anderson CK, Clark PB (1975) Sarcoidosis of the penis treated by radiotherapy. Br J Urol 47:325–330PubMedGoogle Scholar
  193. Williams OE, Kynaston H, Dixon G, Arya OP (1992) Amyloid tumour of the urethra presenting as non-specific urethritis. Genitourin Med 68:332–333PubMedGoogle Scholar
  194. Woods M, Pattee SF, Levine N (2006) Penile calciphylaxis. J Am Acad Dermatol 54:736–737PubMedGoogle Scholar
  195. Yavas US, Calisir C, Kaya T (2007) Vasculogenic impotence as a symptom in late-onset Buerger’s disease. J Clin Ultrasound 35:469–472PubMedGoogle Scholar
  196. Yong HS, Woo OH, Lee JW, Suh SI, Oh YW, Kang EY (2007) Primary localized amyloidosis manifested as supraclavicular and mediastinal lymphadenopathy. Br J Radiol 80:131–133Google Scholar
  197. Yoshii N, Kanekura T, Higashi Y, Oyama K, Azagami K, Kanzaki T (2007) Erythema elevatum diutinum manifesting as a penile ulcer. Clin Exp Dermatol 32:211–213PubMedGoogle Scholar
  198. Zawar V, Godse K (2011) Annular groin eruptions: pityriasis rosea of vidal. Int J Dermatol 50:195–197PubMedGoogle Scholar
  199. Zawar V, Kumar R (2009) Multiple recurrences of pityriasis rosea of Vidal: a novel presentation. Clin Exp Dermatol 34:e114–e116PubMedGoogle Scholar
  200. Zhuge Y, Hogan AR, Cheung MC, Neville HL, Thompson WR, Birusingh R, Sola JE (2009) Thrombotic cutaneous gangrene with autoamputation of the penis: a rare extracolonic manifestation of ulcerative colitis in a child. J Pediatr Surg 44:e1–e4PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Alberto Rosenblatt
    • 1
  • Homero Gustavo de Campos Guidi
    • 2
  • Walter BeldaJr.
    • 3
  1. 1.Albert Einstein Jewish Hospital (HIAE)São PauloBrazil
  2. 2.University of São Paulo Medical SchoolSão PauloBrazil
  3. 3.Department of DermatologyUniversity of São Paulo Medical SchoolSão PauloBrazil

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