Fabrication of Biodegradable Poly(Lactic Acid) Particles in Flow-Focusing Glass Capillary Devices

  • Goran T. Vladisavljević
  • J. V. Henry
  • Wynter J. Duncanson
  • Ho C. Shum
  • David A. Weitz
Conference paper
Part of the Progress in Colloid and Polymer Science book series (PROGCOLLOID, volume 139)

Abstract

Monodisperse poly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 μm were fabricated in flow focusing glass capillary devices by evaporation of dichloromethane (DCM) from emulsions at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing a small amount of Nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the size of the emulsion droplet template indicating that the particle porosity was very low. SEM images revealed that the majority of particle pores are in the sub-micron region but in some instances these pores can reach 3 μm in diameter. Droplet diameter was influenced by the flow rates of the two phases and the entry diameter of the collection capillary tube; droplet diameters decreased with increasing values of the flow rate ratio of the dispersed to continuous phase to reach constant minimum values at 40–60% orifice diameter. At flow rate ratios less than 5, jetting can occur, giving rise to large droplets formed by detachment from relatively long jets (~10 times longer than droplet diameter).

Keywords

Droplet Diameter Flow Rate Ratio Reverse Osmosis Water PLGA Particle Drop Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgment

The work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom (grant reference number: EP/HO29923/1).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Goran T. Vladisavljević
    • 1
    • 2
  • J. V. Henry
    • 1
  • Wynter J. Duncanson
    • 3
  • Ho C. Shum
    • 4
  • David A. Weitz
    • 3
  1. 1.Department of Chemical EngineeringLoughborough UniversityLoughboroughUK
  2. 2.Vinca Institute of Nuclear SciencesUniversity of BelgradeBelgradeSerbia
  3. 3.Department of PhysicsHarvard UniversityCambridgeUSA
  4. 4.Department of Mechanical EngineeringUniversity of Hong KongHong KongChina

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