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Introduction to Antibiotic Resistance

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Antibiotic Resistance

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 211))

Abstract

The inexorable rise in multidrug-resistant Gram-negative bacteria has been widely reported. Multiple modes of resistance often present in a single strain of bacteria, and this may also be combined with an increase in virulence, both of which are leading to a significant increase in morbidity and mortality in patients. Against this background, the absolute number of new antibiotics licensed has declined especially for Gram-negative multidrug-resistant pathogens. The reasons for this failure are presented here: market issues, big pharma changes, regulatory constraints, difficulties in finding drugable targets and, lastly, suitable compounds worthy of full development.

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Authors and Affiliations

  1. TranScrip Partners LLP, 400 Thames Valley, Park Drive, Reading, RG6 1PT, UK

    Richard Bax & David Griffin

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  1. Richard Bax
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  2. David Griffin
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Corresponding author

Correspondence to Richard Bax .

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Editors and Affiliations

  1. , Div of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom

    Anthony R.M. Coates

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© 2012 Springer-Verlag Berlin Heidelberg

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Bax, R., Griffin, D. (2012). Introduction to Antibiotic Resistance. In: Coates, A. (eds) Antibiotic Resistance. Handbook of Experimental Pharmacology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28951-4_1

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