Pediatric Central Nervous System Tumors

  • Jeffrey C. Buchsbaum
  • Arnold C. Paulino


Volumetric planning in the form of proton therapy, intensity-modulated radiation therapy (IMRT), and three-dimensional (3D) conformal therapy is the standard technique for definitive craniospinal irradiation (CSI) and boost radiation therapy for medulloblastoma. These volumetric methods each can be delivered using a number of techniques; however, accurate delineation of target volumes is universally required.


Target Volume Clinical Target Volume Laryngeal Mask Airway Proton Therapy Volumetric Method 
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Further Reading

  1. Merchant TE, Li C, Xiong X et al (2009) Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study. Lancet Oncol 10:258–266PubMedCrossRefGoogle Scholar
  2. Paulino AC, Mazloom A, Teh BS et al (2011) Local control after craniospinal irradiation, ­intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma. Cancer 117:635–641PubMedCrossRefGoogle Scholar
  3. Raggi E, Mosleh-Shirazi MA, Saran FH (2008) An evaluation of conformal and intensity-­modulated radiotherapy in whole ventricular radiotherapy for localized primary intracranial germinomas. Clin Oncol (R Coll Radiol) 20:253–260CrossRefGoogle Scholar
  4. Roberge D, Kun LE, Freeman CR (2005) Intracranial germinoma: on whole-ventricular ­irradiation. Pediatr Blood Cancer 44:358–362PubMedCrossRefGoogle Scholar
  5. Wolden SL, Dunkel IJ, Souweidane MM et al (2003) Patterns of failure using a conformal ­radiation therapy tumor bed boost for medulloblastoma. J Clin Oncol 21:3079–3083PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Radiation OncologyIU School of Medicine, Riley Hospital for Children, IU Health Proton Therapy CenterBloomingtonUSA
  2. 2.Department of PediatricsIU School of Medicine, Riley Hospital for ChildrenIndianapolisUSA
  3. 3.Department of Neurological SurgeryIU School of MedicineIndianapolisUSA
  4. 4.Department of Radiation OncologyThe Methodist HospitalHoustonUSA
  5. 5.Department of PediatricsBaylor College of MedicineHoustonUSA
  6. 6.Department of Radiation OncologyWeill Cornell Medical CollegeNew YorkUSA

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