Ectopic Foci Study on the Crest Terminalis in 3D Computer Model of Human Atrial

  • Carlos A. Ruiz-Villa
  • Andrés P. Castaño
  • Andrés Castillo
  • Elvio Heidenreich
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 154)


Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Epidemiological studies show that AF tends to persist over time, creating electrophysiological and anatomical changes called remodeled atrial. It has been shown that these changes result in variations in conduction velocity (CV) in the atrial tissue. The changes caused by electrical remodeling in a model of action potential (AP) of atrial myocytes have been incorpotated in this study, coupled with an anatomically realistic three-dimensional model of human dilated atrium. Simulations of the spread of AP in terms of anatomical and electrical remodeling and remodeling of gap junctions were measured vulnerable windows of reentry generation on the crest terminalis of the atrium. The results obtained indicate that vulnerable window in the remodeling of gap junctions shifted 38 ms with respect to the model dilated, which shows the impact of structural remodeling Several types of permanent reentry of figures in form of eight and in form of rotor, favored by the underlying anatomy of the atrium were obtained.


Atrial fibrillation electrical remodeling action potential cresta terminalis reentry 3D model 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Carlos A. Ruiz-Villa
    • 1
    • 4
  • Andrés P. Castaño
    • 1
  • Andrés Castillo
    • 2
  • Elvio Heidenreich
    • 3
  1. 1.Center for Research and Innovation in EngineeringUniversity of CaldasManizalesColombia
  2. 2.Language, Informatics Systems and Software Engineer DepartmentPontifical University of SalamancaMadridSpain
  3. 3.Engineering FacultyUniversity of Lomas of ZamoraBuenos AiresArgentina
  4. 4.Informatic and Computation DepartmentNational University of ColombiaManizalesColombia

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